Prevalence of DSM-5 mild and major neurocognitive disorder in India: Results from the LASI-DAD.
<h4>Introduction</h4>India, with its rapidly aging population, faces an alarming burden of dementia. We implemented DSM-5 criteria in large-scale, nationally representative survey data in India to characterize the prevalence of mild and major Neurocognitive disorder.<h4>Methods<...
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Public Library of Science (PLoS)
2024-01-01
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| author | Alden L Gross Emma Nichols Marco Angrisani Mary Ganguli Haomiao Jin Pranali Khobragade Kenneth M Langa Erik Meijer Mathew Varghese A B Dey Jinkook Lee |
| author_facet | Alden L Gross Emma Nichols Marco Angrisani Mary Ganguli Haomiao Jin Pranali Khobragade Kenneth M Langa Erik Meijer Mathew Varghese A B Dey Jinkook Lee |
| author_sort | Alden L Gross |
| collection | DOAJ |
| description | <h4>Introduction</h4>India, with its rapidly aging population, faces an alarming burden of dementia. We implemented DSM-5 criteria in large-scale, nationally representative survey data in India to characterize the prevalence of mild and major Neurocognitive disorder.<h4>Methods</h4>The Harmonized Diagnostic Assessment of Dementia for the Longitudinal Aging Study in India (LASI-DAD) (N = 4,096) is a nationally representative cohort study in India using multistage area probability sampling methods. Using neuropsychological testing and informant reports, we defined DSM-5 mild and major neurocognitive disorder, reported its prevalence, and evaluated criterion and construct validity of the algorithm using clinician-adjudicated Clinical Dementia Ratings (CDR)®.<h4>Results</h4>The prevalence of mild and major neurocognitive disorder, weighted to the population, is 17.6% and 7.2%. Demographic gradients with respect to age and education conform to hypothesized patterns. Among N = 2,390 participants with a clinician-adjudicated CDR, CDR ratings and DSM-5 classification agreed for N = 2,139 (89.5%) participants.<h4>Discussion</h4>The prevalence of dementia in India is higher than previously recognized. These findings, coupled with a growing number of older adults in the coming decades in India, have important implications for society, public health, and families. We are aware of no previous Indian population-representative estimates of mild cognitive impairment, a group which will be increasingly important in coming years to identify for potential therapeutic treatment. |
| first_indexed | 2024-03-08T00:14:48Z |
| format | Article |
| id | doaj.art-11e3fb33cd8b4e8385e571c0dddf33c7 |
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| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-03-08T00:14:48Z |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-11e3fb33cd8b4e8385e571c0dddf33c72024-02-17T05:33:11ZengPublic Library of Science (PLoS)PLoS ONE1932-62032024-01-01192e029722010.1371/journal.pone.0297220Prevalence of DSM-5 mild and major neurocognitive disorder in India: Results from the LASI-DAD.Alden L GrossEmma NicholsMarco AngrisaniMary GanguliHaomiao JinPranali KhobragadeKenneth M LangaErik MeijerMathew VargheseA B DeyJinkook Lee<h4>Introduction</h4>India, with its rapidly aging population, faces an alarming burden of dementia. We implemented DSM-5 criteria in large-scale, nationally representative survey data in India to characterize the prevalence of mild and major Neurocognitive disorder.<h4>Methods</h4>The Harmonized Diagnostic Assessment of Dementia for the Longitudinal Aging Study in India (LASI-DAD) (N = 4,096) is a nationally representative cohort study in India using multistage area probability sampling methods. Using neuropsychological testing and informant reports, we defined DSM-5 mild and major neurocognitive disorder, reported its prevalence, and evaluated criterion and construct validity of the algorithm using clinician-adjudicated Clinical Dementia Ratings (CDR)®.<h4>Results</h4>The prevalence of mild and major neurocognitive disorder, weighted to the population, is 17.6% and 7.2%. Demographic gradients with respect to age and education conform to hypothesized patterns. Among N = 2,390 participants with a clinician-adjudicated CDR, CDR ratings and DSM-5 classification agreed for N = 2,139 (89.5%) participants.<h4>Discussion</h4>The prevalence of dementia in India is higher than previously recognized. These findings, coupled with a growing number of older adults in the coming decades in India, have important implications for society, public health, and families. We are aware of no previous Indian population-representative estimates of mild cognitive impairment, a group which will be increasingly important in coming years to identify for potential therapeutic treatment.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0297220&type=printable |
| spellingShingle | Alden L Gross Emma Nichols Marco Angrisani Mary Ganguli Haomiao Jin Pranali Khobragade Kenneth M Langa Erik Meijer Mathew Varghese A B Dey Jinkook Lee Prevalence of DSM-5 mild and major neurocognitive disorder in India: Results from the LASI-DAD. PLoS ONE |
| title | Prevalence of DSM-5 mild and major neurocognitive disorder in India: Results from the LASI-DAD. |
| title_full | Prevalence of DSM-5 mild and major neurocognitive disorder in India: Results from the LASI-DAD. |
| title_fullStr | Prevalence of DSM-5 mild and major neurocognitive disorder in India: Results from the LASI-DAD. |
| title_full_unstemmed | Prevalence of DSM-5 mild and major neurocognitive disorder in India: Results from the LASI-DAD. |
| title_short | Prevalence of DSM-5 mild and major neurocognitive disorder in India: Results from the LASI-DAD. |
| title_sort | prevalence of dsm 5 mild and major neurocognitive disorder in india results from the lasi dad |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0297220&type=printable |
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