How metformin affects various malignancies by means of microRNAs: a brief review
Abstract Metformin known as the first-line orally prescribed drug for lowering blood glucose in type II diabetes (T2DM) has recently found various therapeutic applications including in cancer. Metformin has been studied for its influences in prevention and treatment of cancer through multiple mechan...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-04-01
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| Series: | Cancer Cell International |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12935-021-01921-z |
| _version_ | 1818445815935401984 |
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| author | Nahid Alimoradi Negar Firouzabadi Reihaneh Fatehi |
| author_facet | Nahid Alimoradi Negar Firouzabadi Reihaneh Fatehi |
| author_sort | Nahid Alimoradi |
| collection | DOAJ |
| description | Abstract Metformin known as the first-line orally prescribed drug for lowering blood glucose in type II diabetes (T2DM) has recently found various therapeutic applications including in cancer. Metformin has been studied for its influences in prevention and treatment of cancer through multiple mechanisms such as microRNA (miR) regulation. Alteration in the expression of miRs by metformin may play an important role in the treatment of various cancers. MiRs are single-stranded RNAs that are involved in gene regulation. By binding to the 3′UTR of target mRNAs, miRs influence protein levels. Irregularities in the expression of miRs that control the expression of oncogenes and tumor suppressor genes are associated with the onset and progression of cancer. Metformin may possess an effect on tumor prevention and progression by modifying miR expression and downstream pathways. Here, we summarize the effect of metformin on different types of cancer by regulating the expression of various miRs and the associated downstream molecules. |
| first_indexed | 2024-12-14T19:37:50Z |
| format | Article |
| id | doaj.art-11e52c45fe594035b2ccd6bfb0089180 |
| institution | Directory Open Access Journal |
| issn | 1475-2867 |
| language | English |
| last_indexed | 2024-12-14T19:37:50Z |
| publishDate | 2021-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Cell International |
| spelling | doaj.art-11e52c45fe594035b2ccd6bfb00891802022-12-21T22:49:50ZengBMCCancer Cell International1475-28672021-04-0121111310.1186/s12935-021-01921-zHow metformin affects various malignancies by means of microRNAs: a brief reviewNahid Alimoradi0Negar Firouzabadi1Reihaneh Fatehi2Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical SciencesDepartment of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical SciencesDepartment of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical SciencesAbstract Metformin known as the first-line orally prescribed drug for lowering blood glucose in type II diabetes (T2DM) has recently found various therapeutic applications including in cancer. Metformin has been studied for its influences in prevention and treatment of cancer through multiple mechanisms such as microRNA (miR) regulation. Alteration in the expression of miRs by metformin may play an important role in the treatment of various cancers. MiRs are single-stranded RNAs that are involved in gene regulation. By binding to the 3′UTR of target mRNAs, miRs influence protein levels. Irregularities in the expression of miRs that control the expression of oncogenes and tumor suppressor genes are associated with the onset and progression of cancer. Metformin may possess an effect on tumor prevention and progression by modifying miR expression and downstream pathways. Here, we summarize the effect of metformin on different types of cancer by regulating the expression of various miRs and the associated downstream molecules.https://doi.org/10.1186/s12935-021-01921-zMetforminMicroRNAsCancerAMPKBiomarkerMechanism of action |
| spellingShingle | Nahid Alimoradi Negar Firouzabadi Reihaneh Fatehi How metformin affects various malignancies by means of microRNAs: a brief review Cancer Cell International Metformin MicroRNAs Cancer AMPK Biomarker Mechanism of action |
| title | How metformin affects various malignancies by means of microRNAs: a brief review |
| title_full | How metformin affects various malignancies by means of microRNAs: a brief review |
| title_fullStr | How metformin affects various malignancies by means of microRNAs: a brief review |
| title_full_unstemmed | How metformin affects various malignancies by means of microRNAs: a brief review |
| title_short | How metformin affects various malignancies by means of microRNAs: a brief review |
| title_sort | how metformin affects various malignancies by means of micrornas a brief review |
| topic | Metformin MicroRNAs Cancer AMPK Biomarker Mechanism of action |
| url | https://doi.org/10.1186/s12935-021-01921-z |
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