Toxoplasmosis: A Timeless Challenge for Pregnancy
This study aimed to evaluate the prevalence of toxoplasmosis in pregnant women, as well as the general characteristics, clinical and laboratory findings, and pregnancy and fetal outcomes of pregnant women diagnosed with acute toxoplasma infection (ATI). The toxoplasma IgM, IgG, and IgG avidity test...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Tropical Medicine and Infectious Disease |
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| Online Access: | https://www.mdpi.com/2414-6366/8/1/63 |
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| author | Tuba Damar Çakırca İlkay Nur Can Melis Deniz Ayşe Torun Çiğdem Akçabay Ahmet Güzelçiçek |
| author_facet | Tuba Damar Çakırca İlkay Nur Can Melis Deniz Ayşe Torun Çiğdem Akçabay Ahmet Güzelçiçek |
| author_sort | Tuba Damar Çakırca |
| collection | DOAJ |
| description | This study aimed to evaluate the prevalence of toxoplasmosis in pregnant women, as well as the general characteristics, clinical and laboratory findings, and pregnancy and fetal outcomes of pregnant women diagnosed with acute toxoplasma infection (ATI). The toxoplasma IgM, IgG, and IgG avidity test results of pregnant women who applied to our referral hospital between January 2016 and June 2022, and among them, those diagnosed with ATI, were analyzed. The 119 patients diagnosed with ATI during this time period were included for further analysis. The prevalence of toxoplasmosis in pregnant women was found to be 46.2%, and the rate of ATI was 4%. The total mother-to-child transmission rate was 5% (5/101). Congenital toxoplasmosis (CT) was observed in 1 (1.1%) child of the 87 pregnant women who received spiramycin prophylaxis, though it was found in 4 (30.8%) of the children of the 13 untreated mothers. With respect to prenatal treatment, CT rates were significantly higher in the children born to untreated mothers (<i>p</i> = 0.001). In conclusion, although toxoplasma seroprevalence was found to be high in our region, there was a paucity in diagnosis, follow-up, and treatment. Our findings support that prenatal spiramycin prophylaxis is effective in preventing the transmission of parasites from mother to child. |
| first_indexed | 2024-03-09T11:04:50Z |
| format | Article |
| id | doaj.art-11e78a31a1b74cbaa6da086845cf7c89 |
| institution | Directory Open Access Journal |
| issn | 2414-6366 |
| language | English |
| last_indexed | 2024-03-09T11:04:50Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Tropical Medicine and Infectious Disease |
| spelling | doaj.art-11e78a31a1b74cbaa6da086845cf7c892023-12-01T00:58:37ZengMDPI AGTropical Medicine and Infectious Disease2414-63662023-01-01816310.3390/tropicalmed8010063Toxoplasmosis: A Timeless Challenge for PregnancyTuba Damar Çakırca0İlkay Nur Can1Melis Deniz2Ayşe Torun3Çiğdem Akçabay4Ahmet Güzelçiçek5Department of Infectious Diseases and Clinical Microbiology, Sanliurfa Training and Research Hospital, Sanliurfa 63250, TurkeyDepartment of Infectious Diseases and Clinical Microbiology, Sanliurfa Training and Research Hospital, Sanliurfa 63250, TurkeyDepartment of Pediatric Infectious Diseases, Sanliurfa Training and Research Hospital, Sanliurfa 63250, TurkeyDepartment of Infectious Diseases and Clinical Microbiology, Sanliurfa Training and Research Hospital, Sanliurfa 63250, TurkeyDepartment of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Sanliurfa Training and Research Hospital, Sanliurfa 63250, TurkeyDepartment of Pediatrics, Harran University Faculty of Medicine, Sanliurfa 63290, TurkeyThis study aimed to evaluate the prevalence of toxoplasmosis in pregnant women, as well as the general characteristics, clinical and laboratory findings, and pregnancy and fetal outcomes of pregnant women diagnosed with acute toxoplasma infection (ATI). The toxoplasma IgM, IgG, and IgG avidity test results of pregnant women who applied to our referral hospital between January 2016 and June 2022, and among them, those diagnosed with ATI, were analyzed. The 119 patients diagnosed with ATI during this time period were included for further analysis. The prevalence of toxoplasmosis in pregnant women was found to be 46.2%, and the rate of ATI was 4%. The total mother-to-child transmission rate was 5% (5/101). Congenital toxoplasmosis (CT) was observed in 1 (1.1%) child of the 87 pregnant women who received spiramycin prophylaxis, though it was found in 4 (30.8%) of the children of the 13 untreated mothers. With respect to prenatal treatment, CT rates were significantly higher in the children born to untreated mothers (<i>p</i> = 0.001). In conclusion, although toxoplasma seroprevalence was found to be high in our region, there was a paucity in diagnosis, follow-up, and treatment. Our findings support that prenatal spiramycin prophylaxis is effective in preventing the transmission of parasites from mother to child.https://www.mdpi.com/2414-6366/8/1/63congenital toxoplasmosiscongenital infectionspregnancyprenatal diagnosisspiramycin prophylaxis |
| spellingShingle | Tuba Damar Çakırca İlkay Nur Can Melis Deniz Ayşe Torun Çiğdem Akçabay Ahmet Güzelçiçek Toxoplasmosis: A Timeless Challenge for Pregnancy Tropical Medicine and Infectious Disease congenital toxoplasmosis congenital infections pregnancy prenatal diagnosis spiramycin prophylaxis |
| title | Toxoplasmosis: A Timeless Challenge for Pregnancy |
| title_full | Toxoplasmosis: A Timeless Challenge for Pregnancy |
| title_fullStr | Toxoplasmosis: A Timeless Challenge for Pregnancy |
| title_full_unstemmed | Toxoplasmosis: A Timeless Challenge for Pregnancy |
| title_short | Toxoplasmosis: A Timeless Challenge for Pregnancy |
| title_sort | toxoplasmosis a timeless challenge for pregnancy |
| topic | congenital toxoplasmosis congenital infections pregnancy prenatal diagnosis spiramycin prophylaxis |
| url | https://www.mdpi.com/2414-6366/8/1/63 |
| work_keys_str_mv | AT tubadamarcakırca toxoplasmosisatimelesschallengeforpregnancy AT ilkaynurcan toxoplasmosisatimelesschallengeforpregnancy AT melisdeniz toxoplasmosisatimelesschallengeforpregnancy AT aysetorun toxoplasmosisatimelesschallengeforpregnancy AT cigdemakcabay toxoplasmosisatimelesschallengeforpregnancy AT ahmetguzelcicek toxoplasmosisatimelesschallengeforpregnancy |