Sonosensitive MRI Nanosystems as Cancer Theranostics: A Recent Update
In the tireless search for innovative and more efficient cancer therapies, sonosensitive Magnetic Resonance Imaging (MRI) agents play an important role. Basically, these systems consist of nano/microvesicles composed by a biocompatible membrane, responsive to ultrasound-induced thermal or mechanical...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-05-01
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| Series: | Frontiers in Chemistry |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fchem.2018.00157/full |
| _version_ | 1811232512649723904 |
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| author | Francesca Garello Enzo Terreno |
| author_facet | Francesca Garello Enzo Terreno |
| author_sort | Francesca Garello |
| collection | DOAJ |
| description | In the tireless search for innovative and more efficient cancer therapies, sonosensitive Magnetic Resonance Imaging (MRI) agents play an important role. Basically, these systems consist of nano/microvesicles composed by a biocompatible membrane, responsive to ultrasound-induced thermal or mechanical effects, and an aqueous core, filled up with a MRI detectable probe and a therapeutic agent. They offer the possibility to trigger and monitor in real time drug release in a spatio-temporal domain, with the expectation to predict the therapeutic outcome. In this review, the key items to design sonosensitive MRI agents will be examined and an overview on the different approaches available so far will be given. Due to the extremely wide range of adopted ultrasound settings and formulations conceived, it is hard to compare the numerous preclinical studies reported. However, in general, a significantly better therapeutic outcome was noticed when exploiting ultrasound triggered drug release in comparison to traditional therapies, thus paving the way to the possible clinical translation of optimized sonosensitive MRI agents. |
| first_indexed | 2024-04-12T11:04:07Z |
| format | Article |
| id | doaj.art-11eb9e8234f64dd088eb7fd151e39790 |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-04-12T11:04:07Z |
| publishDate | 2018-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-11eb9e8234f64dd088eb7fd151e397902022-12-22T03:35:50ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462018-05-01610.3389/fchem.2018.00157360873Sonosensitive MRI Nanosystems as Cancer Theranostics: A Recent UpdateFrancesca GarelloEnzo TerrenoIn the tireless search for innovative and more efficient cancer therapies, sonosensitive Magnetic Resonance Imaging (MRI) agents play an important role. Basically, these systems consist of nano/microvesicles composed by a biocompatible membrane, responsive to ultrasound-induced thermal or mechanical effects, and an aqueous core, filled up with a MRI detectable probe and a therapeutic agent. They offer the possibility to trigger and monitor in real time drug release in a spatio-temporal domain, with the expectation to predict the therapeutic outcome. In this review, the key items to design sonosensitive MRI agents will be examined and an overview on the different approaches available so far will be given. Due to the extremely wide range of adopted ultrasound settings and formulations conceived, it is hard to compare the numerous preclinical studies reported. However, in general, a significantly better therapeutic outcome was noticed when exploiting ultrasound triggered drug release in comparison to traditional therapies, thus paving the way to the possible clinical translation of optimized sonosensitive MRI agents.http://journal.frontiersin.org/article/10.3389/fchem.2018.00157/fullsonosensitive agentsimage-guided drug releaseultrasoundsmagnetic resonance imagingtheranosticsthermosensitive liposomes |
| spellingShingle | Francesca Garello Enzo Terreno Sonosensitive MRI Nanosystems as Cancer Theranostics: A Recent Update Frontiers in Chemistry sonosensitive agents image-guided drug release ultrasounds magnetic resonance imaging theranostics thermosensitive liposomes |
| title | Sonosensitive MRI Nanosystems as Cancer Theranostics: A Recent Update |
| title_full | Sonosensitive MRI Nanosystems as Cancer Theranostics: A Recent Update |
| title_fullStr | Sonosensitive MRI Nanosystems as Cancer Theranostics: A Recent Update |
| title_full_unstemmed | Sonosensitive MRI Nanosystems as Cancer Theranostics: A Recent Update |
| title_short | Sonosensitive MRI Nanosystems as Cancer Theranostics: A Recent Update |
| title_sort | sonosensitive mri nanosystems as cancer theranostics a recent update |
| topic | sonosensitive agents image-guided drug release ultrasounds magnetic resonance imaging theranostics thermosensitive liposomes |
| url | http://journal.frontiersin.org/article/10.3389/fchem.2018.00157/full |
| work_keys_str_mv | AT francescagarello sonosensitivemrinanosystemsascancertheranosticsarecentupdate AT enzoterreno sonosensitivemrinanosystemsascancertheranosticsarecentupdate |