Transplacental transfer of acetaminophen in pregnant rats

Transplacental transfer of acetaminophen in pregnant rats

Acetaminophen is among the most widely used analgesics; however, the proportion and mechanism of transplacental transfer of unbound acetaminophen with actual pharmacological activity remain unknown. Our hypothesis is that acetaminophen gradually penetrates the blood-placenta barrier to reach the fet...

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Bibliographic Details
Main Authors:	Jung-Hung Chen, I-Hsin Lin, Chung-Kai Sun, Ling Yang, Thomas Y. Hsueh, Chin-Tsung Ting, Tung-Hu Tsai
Format:	Article
Language:	English
Published:	Elsevier 2022-10-01
Series:	Biomedicine & Pharmacotherapy
Subjects:	Acetaminophen Microdialysis Pharmacokinetics Transplacental transfer
Online Access:	http://www.sciencedirect.com/science/article/pii/S0753332222010022

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