Mechanisms Mediating Antigenic Variation in Trypanosoma brucei
Antigenic variation in Trypanosoma brucei is a highly sophisticated survival strategy involving switching between the transcription of one of an estimated thousand variant surface glycoprotein (VSG) genes. Switching involves either transcriptional control, resulting in switching between different VS...
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
1999-01-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761999000200021 |
| _version_ | 1797715692107071488 |
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| author | Rudenko Gloria |
| author_facet | Rudenko Gloria |
| author_sort | Rudenko Gloria |
| collection | DOAJ |
| description | Antigenic variation in Trypanosoma brucei is a highly sophisticated survival strategy involving switching between the transcription of one of an estimated thousand variant surface glycoprotein (VSG) genes. Switching involves either transcriptional control, resulting in switching between different VSG expression sites; or DNA rearrangement events slotting previously inactive VSG genes into an active VSG expression site. In recent years, considerable progress has been made in techniques allowing us to genetically modify infective bloodstream form trypanosomes. This is allowing us to reengineer VSG expression sites, and look at the effect on the mechanisms subsequently used for antigenic variation. We can now begin a dissection of a highly complicated survival strategy mediated by many different mechanisms operating simultaneously. |
| first_indexed | 2024-03-12T08:10:26Z |
| format | Article |
| id | doaj.art-11eceac0d8e440a9ae1401f9587aa882 |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T08:10:26Z |
| publishDate | 1999-01-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-11eceac0d8e440a9ae1401f9587aa8822023-09-02T19:07:03ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80601999-01-01942235237Mechanisms Mediating Antigenic Variation in Trypanosoma bruceiRudenko GloriaAntigenic variation in Trypanosoma brucei is a highly sophisticated survival strategy involving switching between the transcription of one of an estimated thousand variant surface glycoprotein (VSG) genes. Switching involves either transcriptional control, resulting in switching between different VSG expression sites; or DNA rearrangement events slotting previously inactive VSG genes into an active VSG expression site. In recent years, considerable progress has been made in techniques allowing us to genetically modify infective bloodstream form trypanosomes. This is allowing us to reengineer VSG expression sites, and look at the effect on the mechanisms subsequently used for antigenic variation. We can now begin a dissection of a highly complicated survival strategy mediated by many different mechanisms operating simultaneously.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761999000200021antigenic variationTrypanosoma bruceivariant surface glycoprotein (VSG)VSG expression site |
| spellingShingle | Rudenko Gloria Mechanisms Mediating Antigenic Variation in Trypanosoma brucei Memorias do Instituto Oswaldo Cruz antigenic variation Trypanosoma brucei variant surface glycoprotein (VSG) VSG expression site |
| title | Mechanisms Mediating Antigenic Variation in Trypanosoma brucei |
| title_full | Mechanisms Mediating Antigenic Variation in Trypanosoma brucei |
| title_fullStr | Mechanisms Mediating Antigenic Variation in Trypanosoma brucei |
| title_full_unstemmed | Mechanisms Mediating Antigenic Variation in Trypanosoma brucei |
| title_short | Mechanisms Mediating Antigenic Variation in Trypanosoma brucei |
| title_sort | mechanisms mediating antigenic variation in trypanosoma brucei |
| topic | antigenic variation Trypanosoma brucei variant surface glycoprotein (VSG) VSG expression site |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761999000200021 |
| work_keys_str_mv | AT rudenkogloria mechanismsmediatingantigenicvariationintrypanosomabrucei |