Metabolism and physiology of pathogenic bacterial obligate intracellular parasites
Bacterial obligate intracellular parasites (BOIPs) represent an exclusive group of bacterial pathogens that all depend on invasion of a eukaryotic host cell to reproduce. BOIPs are characterized by extensive adaptation to their respective replication niches, regardless of whether they replicate with...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2024.1284701/full |
| _version_ | 1797249260227395584 |
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| author | Cameron G. Mandel Savannah E. Sanchez Savannah E. Sanchez Colleen C. Monahan Weerawat Phuklia Weerawat Phuklia Anders Omsland |
| author_facet | Cameron G. Mandel Savannah E. Sanchez Savannah E. Sanchez Colleen C. Monahan Weerawat Phuklia Weerawat Phuklia Anders Omsland |
| author_sort | Cameron G. Mandel |
| collection | DOAJ |
| description | Bacterial obligate intracellular parasites (BOIPs) represent an exclusive group of bacterial pathogens that all depend on invasion of a eukaryotic host cell to reproduce. BOIPs are characterized by extensive adaptation to their respective replication niches, regardless of whether they replicate within the host cell cytoplasm or within specialized replication vacuoles. Genome reduction is also a hallmark of BOIPs that likely reflects streamlining of metabolic processes to reduce the need for de novo biosynthesis of energetically costly metabolic intermediates. Despite shared characteristics in lifestyle, BOIPs show considerable diversity in nutrient requirements, metabolic capabilities, and general physiology. In this review, we compare metabolic and physiological processes of prominent pathogenic BOIPs with special emphasis on carbon, energy, and amino acid metabolism. Recent advances are discussed in the context of historical views and opportunities for discovery. |
| first_indexed | 2024-04-24T20:27:39Z |
| format | Article |
| id | doaj.art-11eef931e2624757ab2e1ae0385e7160 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-04-24T20:27:39Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-11eef931e2624757ab2e1ae0385e71602024-03-22T04:30:13ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882024-03-011410.3389/fcimb.2024.12847011284701Metabolism and physiology of pathogenic bacterial obligate intracellular parasitesCameron G. Mandel0Savannah E. Sanchez1Savannah E. Sanchez2Colleen C. Monahan3Weerawat Phuklia4Weerawat Phuklia5Anders Omsland6Paul G. Allen School for Global Health, College of Veterinary Medicine, Washington State University, Pullman, WA, United StatesPaul G. Allen School for Global Health, College of Veterinary Medicine, Washington State University, Pullman, WA, United StatesDepartment of Microbiology and Immunology, Virginia Commonwealth University School of Medicine, Richmond, VA, United StatesPaul G. Allen School for Global Health, College of Veterinary Medicine, Washington State University, Pullman, WA, United StatesPaul G. Allen School for Global Health, College of Veterinary Medicine, Washington State University, Pullman, WA, United StatesLao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao People’s Democratic RepublicPaul G. Allen School for Global Health, College of Veterinary Medicine, Washington State University, Pullman, WA, United StatesBacterial obligate intracellular parasites (BOIPs) represent an exclusive group of bacterial pathogens that all depend on invasion of a eukaryotic host cell to reproduce. BOIPs are characterized by extensive adaptation to their respective replication niches, regardless of whether they replicate within the host cell cytoplasm or within specialized replication vacuoles. Genome reduction is also a hallmark of BOIPs that likely reflects streamlining of metabolic processes to reduce the need for de novo biosynthesis of energetically costly metabolic intermediates. Despite shared characteristics in lifestyle, BOIPs show considerable diversity in nutrient requirements, metabolic capabilities, and general physiology. In this review, we compare metabolic and physiological processes of prominent pathogenic BOIPs with special emphasis on carbon, energy, and amino acid metabolism. Recent advances are discussed in the context of historical views and opportunities for discovery.https://www.frontiersin.org/articles/10.3389/fcimb.2024.1284701/fullobligatenutrientgenome streamliningphysiologymetabolismauxotrophy |
| spellingShingle | Cameron G. Mandel Savannah E. Sanchez Savannah E. Sanchez Colleen C. Monahan Weerawat Phuklia Weerawat Phuklia Anders Omsland Metabolism and physiology of pathogenic bacterial obligate intracellular parasites Frontiers in Cellular and Infection Microbiology obligate nutrient genome streamlining physiology metabolism auxotrophy |
| title | Metabolism and physiology of pathogenic bacterial obligate intracellular parasites |
| title_full | Metabolism and physiology of pathogenic bacterial obligate intracellular parasites |
| title_fullStr | Metabolism and physiology of pathogenic bacterial obligate intracellular parasites |
| title_full_unstemmed | Metabolism and physiology of pathogenic bacterial obligate intracellular parasites |
| title_short | Metabolism and physiology of pathogenic bacterial obligate intracellular parasites |
| title_sort | metabolism and physiology of pathogenic bacterial obligate intracellular parasites |
| topic | obligate nutrient genome streamlining physiology metabolism auxotrophy |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2024.1284701/full |
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