Highly Sensitive Room-Temperature Sensor Based on Nanostructured K<sub>2</sub>W<sub>7</sub>O<sub>22</sub> for Application in the Non-Invasive Diagnosis of Diabetes
Diabetes is one of the most rapidly-growing chronic diseases in the world. Acetone, a volatile organic compound in exhaled breath, shows a positive correlation with blood glucose and has proven to be a biomarker for type-1 diabetes. Measuring the level of acetone in exhaled breath can provide a non-...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-10-01
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| Series: | Sensors |
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| Online Access: | https://www.mdpi.com/1424-8220/18/11/3703 |
| _version_ | 1828113535254659072 |
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| author | Md Razuan Hossain Qifeng Zhang Michael Johnson Danling Wang |
| author_facet | Md Razuan Hossain Qifeng Zhang Michael Johnson Danling Wang |
| author_sort | Md Razuan Hossain |
| collection | DOAJ |
| description | Diabetes is one of the most rapidly-growing chronic diseases in the world. Acetone, a volatile organic compound in exhaled breath, shows a positive correlation with blood glucose and has proven to be a biomarker for type-1 diabetes. Measuring the level of acetone in exhaled breath can provide a non-invasive, low risk of infection, low cost, and convenient way to monitor the health condition of diabetics. There has been continuous demand for the improvement of this non-invasive, sensitive sensor system to provide a fast and real-time electronic readout of blood glucose levels. A novel nanostructured K<sub>2</sub>W<sub>7</sub>O<sub>22</sub> has been recently used to test acetone with concentration from 0 parts-per-million (ppm) to 50 ppm at room temperature. The results revealed that a K<sub>2</sub>W<sub>7</sub>O<sub>22</sub> sensor shows a sensitive response to acetone, but the detection limit is not ideal due to the limitations of the detection system of the device. In this paper, we report a K<sub>2</sub>W<sub>7</sub>O<sub>22</sub> sensor with an improved sensitivity and detection limit by using an optimized circuit to minimize the electronic noise and increase the signal to noise ratio for the purpose of weak signal detection while the concentration of acetone is very low. |
| first_indexed | 2024-04-11T12:06:59Z |
| format | Article |
| id | doaj.art-11efc78b826d4fabaa2a9ac6c2cf3754 |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-04-11T12:06:59Z |
| publishDate | 2018-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-11efc78b826d4fabaa2a9ac6c2cf37542022-12-22T04:24:41ZengMDPI AGSensors1424-82202018-10-011811370310.3390/s18113703s18113703Highly Sensitive Room-Temperature Sensor Based on Nanostructured K<sub>2</sub>W<sub>7</sub>O<sub>22</sub> for Application in the Non-Invasive Diagnosis of DiabetesMd Razuan Hossain0Qifeng Zhang1Michael Johnson2Danling Wang3Department of Electrical and Computer Engineering, North Dakota State University, Fargo, ND 58102, USADepartment of Electrical and Computer Engineering, North Dakota State University, Fargo, ND 58102, USAMaterials and Nanotechnology Program, North Dakota State University, Fargo, ND 58102, USADepartment of Electrical and Computer Engineering, North Dakota State University, Fargo, ND 58102, USADiabetes is one of the most rapidly-growing chronic diseases in the world. Acetone, a volatile organic compound in exhaled breath, shows a positive correlation with blood glucose and has proven to be a biomarker for type-1 diabetes. Measuring the level of acetone in exhaled breath can provide a non-invasive, low risk of infection, low cost, and convenient way to monitor the health condition of diabetics. There has been continuous demand for the improvement of this non-invasive, sensitive sensor system to provide a fast and real-time electronic readout of blood glucose levels. A novel nanostructured K<sub>2</sub>W<sub>7</sub>O<sub>22</sub> has been recently used to test acetone with concentration from 0 parts-per-million (ppm) to 50 ppm at room temperature. The results revealed that a K<sub>2</sub>W<sub>7</sub>O<sub>22</sub> sensor shows a sensitive response to acetone, but the detection limit is not ideal due to the limitations of the detection system of the device. In this paper, we report a K<sub>2</sub>W<sub>7</sub>O<sub>22</sub> sensor with an improved sensitivity and detection limit by using an optimized circuit to minimize the electronic noise and increase the signal to noise ratio for the purpose of weak signal detection while the concentration of acetone is very low.https://www.mdpi.com/1424-8220/18/11/3703diabetesacetonebiomarkernon-invasiveblood glucosenanostructured K<sub>2</sub>W<sub>7</sub>O<sub>22</sub>ferroelectric propertyvolatile organic compound |
| spellingShingle | Md Razuan Hossain Qifeng Zhang Michael Johnson Danling Wang Highly Sensitive Room-Temperature Sensor Based on Nanostructured K<sub>2</sub>W<sub>7</sub>O<sub>22</sub> for Application in the Non-Invasive Diagnosis of Diabetes Sensors diabetes acetone biomarker non-invasive blood glucose nanostructured K<sub>2</sub>W<sub>7</sub>O<sub>22</sub> ferroelectric property volatile organic compound |
| title | Highly Sensitive Room-Temperature Sensor Based on Nanostructured K<sub>2</sub>W<sub>7</sub>O<sub>22</sub> for Application in the Non-Invasive Diagnosis of Diabetes |
| title_full | Highly Sensitive Room-Temperature Sensor Based on Nanostructured K<sub>2</sub>W<sub>7</sub>O<sub>22</sub> for Application in the Non-Invasive Diagnosis of Diabetes |
| title_fullStr | Highly Sensitive Room-Temperature Sensor Based on Nanostructured K<sub>2</sub>W<sub>7</sub>O<sub>22</sub> for Application in the Non-Invasive Diagnosis of Diabetes |
| title_full_unstemmed | Highly Sensitive Room-Temperature Sensor Based on Nanostructured K<sub>2</sub>W<sub>7</sub>O<sub>22</sub> for Application in the Non-Invasive Diagnosis of Diabetes |
| title_short | Highly Sensitive Room-Temperature Sensor Based on Nanostructured K<sub>2</sub>W<sub>7</sub>O<sub>22</sub> for Application in the Non-Invasive Diagnosis of Diabetes |
| title_sort | highly sensitive room temperature sensor based on nanostructured k sub 2 sub w sub 7 sub o sub 22 sub for application in the non invasive diagnosis of diabetes |
| topic | diabetes acetone biomarker non-invasive blood glucose nanostructured K<sub>2</sub>W<sub>7</sub>O<sub>22</sub> ferroelectric property volatile organic compound |
| url | https://www.mdpi.com/1424-8220/18/11/3703 |
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