Urinary BK virus excretion in children newly diagnosed with acute lymphoblastic leukemia
Background: Determining the risk factors in developing or increasing the relapses of acute lymphoblastic leukemia (ALL) may help health and preventive systems to launch new programs. Up to 90% of normal population changes to seropositive for BK virus by the age of 10 years. Whether this oncogenic vi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2012-01-01
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| Series: | International Journal of Preventive Medicine |
| Subjects: | |
| Online Access: | http://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2012;volume=3;issue=6;spage=402;epage=407;aulast=Raeesi |
| _version_ | 1818910950063865856 |
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| author | Nahid Raeesi Alaleh Gheissari Marzieh Akrami Sharareh Moghim |
| author_facet | Nahid Raeesi Alaleh Gheissari Marzieh Akrami Sharareh Moghim |
| author_sort | Nahid Raeesi |
| collection | DOAJ |
| description | Background: Determining the risk factors in developing or increasing the relapses of acute lymphoblastic leukemia (ALL) may help health and preventive systems to launch new programs. Up to 90% of normal population changes to seropositive for BK virus by the age of 10 years. Whether this oncogenic virus is responsible for evolving ALL is unclear. In this study, we evaluated the excretion of urinary BK virus in newly diagnosed children with ALL compared with normal population.
Methods: This case-control study was carried out on 62 participants (32 ALL patients and 32 normal subjects), aged 1-18 years, in Saint Al-Zahra and Sayyed-Al-Shohada University Hospitals, Isfahan, Iran. A polymerase chain reaction (PCR) method was used to detect the BK virus in specimens. PCR amplification was performed using specific primers of PEP-1 (5′-AGTCTTTAGGGTCTTCTACC-3′) and PEP-2 (5′-GGTGCCAACCTATGGAACAG-3′).
Results: Thirty-five out of 62 participants (54.8%) were males and the remaining were females. The mean duration of disease was 9.6 ± 9.69 months. Central nervous system (CNS) relapse was seen in 29% of the patients. Positive PCR for urine BK virus was seen in three children with ALL (9.7%). No positive result for urine BKV was achieved in the control group. However, Fisher′s exact test did not show any significant difference between the two groups (P > 0.05). In addition, there was no significant correlation between BKV positivity and frequency of relapses.
Conclusion: To demonstrate the role of BK virus in inducing ALL or increasing the number of relapses, prospective studies on larger scale of population and evaluating both serum and urine for BK virus are recommended. |
| first_indexed | 2024-12-19T22:50:56Z |
| format | Article |
| id | doaj.art-11efdc16cee04df083690e3cdc77513a |
| institution | Directory Open Access Journal |
| issn | 2008-7802 2008-8213 |
| language | English |
| last_indexed | 2024-12-19T22:50:56Z |
| publishDate | 2012-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | International Journal of Preventive Medicine |
| spelling | doaj.art-11efdc16cee04df083690e3cdc77513a2022-12-21T20:02:47ZengWolters Kluwer Medknow PublicationsInternational Journal of Preventive Medicine2008-78022008-82132012-01-0136402407Urinary BK virus excretion in children newly diagnosed with acute lymphoblastic leukemiaNahid RaeesiAlaleh GheissariMarzieh AkramiSharareh MoghimBackground: Determining the risk factors in developing or increasing the relapses of acute lymphoblastic leukemia (ALL) may help health and preventive systems to launch new programs. Up to 90% of normal population changes to seropositive for BK virus by the age of 10 years. Whether this oncogenic virus is responsible for evolving ALL is unclear. In this study, we evaluated the excretion of urinary BK virus in newly diagnosed children with ALL compared with normal population. Methods: This case-control study was carried out on 62 participants (32 ALL patients and 32 normal subjects), aged 1-18 years, in Saint Al-Zahra and Sayyed-Al-Shohada University Hospitals, Isfahan, Iran. A polymerase chain reaction (PCR) method was used to detect the BK virus in specimens. PCR amplification was performed using specific primers of PEP-1 (5′-AGTCTTTAGGGTCTTCTACC-3′) and PEP-2 (5′-GGTGCCAACCTATGGAACAG-3′). Results: Thirty-five out of 62 participants (54.8%) were males and the remaining were females. The mean duration of disease was 9.6 ± 9.69 months. Central nervous system (CNS) relapse was seen in 29% of the patients. Positive PCR for urine BK virus was seen in three children with ALL (9.7%). No positive result for urine BKV was achieved in the control group. However, Fisher′s exact test did not show any significant difference between the two groups (P > 0.05). In addition, there was no significant correlation between BKV positivity and frequency of relapses. Conclusion: To demonstrate the role of BK virus in inducing ALL or increasing the number of relapses, prospective studies on larger scale of population and evaluating both serum and urine for BK virus are recommended.http://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2012;volume=3;issue=6;spage=402;epage=407;aulast=RaeesiBK virusacute lymphoblastic leukemiachildren |
| spellingShingle | Nahid Raeesi Alaleh Gheissari Marzieh Akrami Sharareh Moghim Urinary BK virus excretion in children newly diagnosed with acute lymphoblastic leukemia International Journal of Preventive Medicine BK virus acute lymphoblastic leukemia children |
| title | Urinary BK virus excretion in children newly diagnosed with acute lymphoblastic leukemia |
| title_full | Urinary BK virus excretion in children newly diagnosed with acute lymphoblastic leukemia |
| title_fullStr | Urinary BK virus excretion in children newly diagnosed with acute lymphoblastic leukemia |
| title_full_unstemmed | Urinary BK virus excretion in children newly diagnosed with acute lymphoblastic leukemia |
| title_short | Urinary BK virus excretion in children newly diagnosed with acute lymphoblastic leukemia |
| title_sort | urinary bk virus excretion in children newly diagnosed with acute lymphoblastic leukemia |
| topic | BK virus acute lymphoblastic leukemia children |
| url | http://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2012;volume=3;issue=6;spage=402;epage=407;aulast=Raeesi |
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