ASSESSMENT OF LYMPHOID NEOPLASM RISK FACTORS IN PEOPLE OCCUPATIONALLY EXPOSED TO PROLONGED IONIZING RADIATION
Objective: To estimate the incidence of malignant neoplasms of lymphoid tissue (MNLT) among employees of the siberian chemical combine (SCC) occupationally exposed to prolonged ionizing radiation.Material and methods. The study included 44,041 employees of the SCC, of whom 16,938 were occupationally...
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Tomsk National Research Medical Center
2020-12-01
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| Series: | Сибирский онкологический журнал |
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| Online Access: | https://www.siboncoj.ru/jour/article/view/1635 |
| _version_ | 1797875771330527232 |
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| author | D. E. Kalinkin A. B. Karpov D. E. Maksimov E. N. Kiriakidi R. M. Takhauov |
| author_facet | D. E. Kalinkin A. B. Karpov D. E. Maksimov E. N. Kiriakidi R. M. Takhauov |
| author_sort | D. E. Kalinkin |
| collection | DOAJ |
| description | Objective: To estimate the incidence of malignant neoplasms of lymphoid tissue (MNLT) among employees of the siberian chemical combine (SCC) occupationally exposed to prolonged ionizing radiation.Material and methods. The study included 44,041 employees of the SCC, of whom 16,938 were occupationally exposed to prolonged low-intensity ionizing radiation (IR). Of 295 cases with hemoblastoses, there were 89 with occupational exposure to IR. The structure and incidence of hemoblastoses (based on the number of person-years of observation, (PYO), as well as the standardized relative risk (SRR) of their development and excess relative risk (err) per unit dose of radiation (GR) were evaluated. Calculation of SRR was carried out for the following intervals of the total dose of external exposure: 0; >0–0.05; >0.05–0.10; >0.10-0.15; >0.15–0.20; >0.20-0.30; >0.30-0.50; >0.5–1.0; ≥ 1.0 Gy. The control group consisted of occupationally non-exposed employees of the SCC. The calculation of SRR and err was performed using the poisson regression using the amfit module of the EPICURE package.Results. The incidence of MNLT among males of SCC was 17.1 per 100,000 PYO, with the highest incidence rates for Non-Hodgkin’s lymphoma (NHL), chronic lymphocytic leukemia (CLL) and chronic leukemia (CL) excluding CLL. Among females of the SCC, the incidence of MNLT was 21.3 per 100,000 PYO. It was found that in none of the intervals of the external exposure there was no statistically significant excess of the SRR compared with the control group. The results of ERR/GY calculation also did not demonstrate the increased risk of hemoblastosis among people occupationally exposed to IR.Conclusion. Occupational exposure in the studied dose range does not increase the risk of developing MNLT. |
| first_indexed | 2024-04-10T01:52:53Z |
| format | Article |
| id | doaj.art-11f0349598114c6fb7ceb06e13a38af9 |
| institution | Directory Open Access Journal |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| last_indexed | 2024-04-10T01:52:53Z |
| publishDate | 2020-12-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj.art-11f0349598114c6fb7ceb06e13a38af92023-03-13T09:05:53ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682020-12-0119671810.21294/1814-4861-2020-19-6-7-18800ASSESSMENT OF LYMPHOID NEOPLASM RISK FACTORS IN PEOPLE OCCUPATIONALLY EXPOSED TO PROLONGED IONIZING RADIATIOND. E. Kalinkin0A. B. Karpov1D. E. Maksimov2E. N. Kiriakidi3R. M. Takhauov4Северский биофизический научный центр ФМБА России; Сибирский государственный медицинский университет Минздрава РоссииСибирский государственный медицинский университет Минздрава РоссииСеверский биофизический научный центр ФМБА РоссииСибирский государственный медицинский университет Минздрава РоссииСеверский биофизический научный центр ФМБА России; Сибирский государственный медицинский университет Минздрава РоссииObjective: To estimate the incidence of malignant neoplasms of lymphoid tissue (MNLT) among employees of the siberian chemical combine (SCC) occupationally exposed to prolonged ionizing radiation.Material and methods. The study included 44,041 employees of the SCC, of whom 16,938 were occupationally exposed to prolonged low-intensity ionizing radiation (IR). Of 295 cases with hemoblastoses, there were 89 with occupational exposure to IR. The structure and incidence of hemoblastoses (based on the number of person-years of observation, (PYO), as well as the standardized relative risk (SRR) of their development and excess relative risk (err) per unit dose of radiation (GR) were evaluated. Calculation of SRR was carried out for the following intervals of the total dose of external exposure: 0; >0–0.05; >0.05–0.10; >0.10-0.15; >0.15–0.20; >0.20-0.30; >0.30-0.50; >0.5–1.0; ≥ 1.0 Gy. The control group consisted of occupationally non-exposed employees of the SCC. The calculation of SRR and err was performed using the poisson regression using the amfit module of the EPICURE package.Results. The incidence of MNLT among males of SCC was 17.1 per 100,000 PYO, with the highest incidence rates for Non-Hodgkin’s lymphoma (NHL), chronic lymphocytic leukemia (CLL) and chronic leukemia (CL) excluding CLL. Among females of the SCC, the incidence of MNLT was 21.3 per 100,000 PYO. It was found that in none of the intervals of the external exposure there was no statistically significant excess of the SRR compared with the control group. The results of ERR/GY calculation also did not demonstrate the increased risk of hemoblastosis among people occupationally exposed to IR.Conclusion. Occupational exposure in the studied dose range does not increase the risk of developing MNLT.https://www.siboncoj.ru/jour/article/view/1635злокачественные новообразования лимфоидной тканирискпрофессиональное облучение. |
| spellingShingle | D. E. Kalinkin A. B. Karpov D. E. Maksimov E. N. Kiriakidi R. M. Takhauov ASSESSMENT OF LYMPHOID NEOPLASM RISK FACTORS IN PEOPLE OCCUPATIONALLY EXPOSED TO PROLONGED IONIZING RADIATION Сибирский онкологический журнал злокачественные новообразования лимфоидной ткани риск профессиональное облучение. |
| title | ASSESSMENT OF LYMPHOID NEOPLASM RISK FACTORS IN PEOPLE OCCUPATIONALLY EXPOSED TO PROLONGED IONIZING RADIATION |
| title_full | ASSESSMENT OF LYMPHOID NEOPLASM RISK FACTORS IN PEOPLE OCCUPATIONALLY EXPOSED TO PROLONGED IONIZING RADIATION |
| title_fullStr | ASSESSMENT OF LYMPHOID NEOPLASM RISK FACTORS IN PEOPLE OCCUPATIONALLY EXPOSED TO PROLONGED IONIZING RADIATION |
| title_full_unstemmed | ASSESSMENT OF LYMPHOID NEOPLASM RISK FACTORS IN PEOPLE OCCUPATIONALLY EXPOSED TO PROLONGED IONIZING RADIATION |
| title_short | ASSESSMENT OF LYMPHOID NEOPLASM RISK FACTORS IN PEOPLE OCCUPATIONALLY EXPOSED TO PROLONGED IONIZING RADIATION |
| title_sort | assessment of lymphoid neoplasm risk factors in people occupationally exposed to prolonged ionizing radiation |
| topic | злокачественные новообразования лимфоидной ткани риск профессиональное облучение. |
| url | https://www.siboncoj.ru/jour/article/view/1635 |
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