Human Skin Lightening Efficacy of Resveratrol and Its Analogs: From in Vitro Studies to Cosmetic Applications
Antioxidants are deemed useful in controlling oxidative stress associated with extrinsic skin aging and pigmentation disorders. Resveratrol is a polyphenol compound found in many edible plants such as <i>Vitis vinifera</i>, and its inhibitory effects on the catalytic activity, gene expre...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-08-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/8/9/332 |
| _version_ | 1797761893957369856 |
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| author | Yong Chool Boo |
| author_facet | Yong Chool Boo |
| author_sort | Yong Chool Boo |
| collection | DOAJ |
| description | Antioxidants are deemed useful in controlling oxidative stress associated with extrinsic skin aging and pigmentation disorders. Resveratrol is a polyphenol compound found in many edible plants such as <i>Vitis vinifera</i>, and its inhibitory effects on the catalytic activity, gene expression, and posttranslational modifications of tyrosinase, a key enzyme in the melanin biosynthetic pathway, provide a mechanistic basis for its antimelanogenic effects seen in melanocytic cells, three-dimensionally reconstituted skin models, and in vivo animal models. As a potent antioxidant and a modulator of nuclear factor erythroid 2-related factor 2 (Nrf2), and sirtuin 1, resveratrol can also regulate multiple signaling pathways associated with inflammation and premature aging. Recent clinical studies have supported the efficacy of resveratrol and its analogs, such as resveratryl triacetate (RTA) and resveratryl triglycolate (RTG), in human skin lightening and antiaging. These findings suggest that resveratrol and its analogs are potentially useful as skin lightening and antiaging agents in cosmetics. |
| first_indexed | 2024-03-12T19:20:33Z |
| format | Article |
| id | doaj.art-11f1c7047a86459b997b99f4f7bf3ca4 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-12T19:20:33Z |
| publishDate | 2019-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-11f1c7047a86459b997b99f4f7bf3ca42023-08-02T05:12:08ZengMDPI AGAntioxidants2076-39212019-08-018933210.3390/antiox8090332antiox8090332Human Skin Lightening Efficacy of Resveratrol and Its Analogs: From in Vitro Studies to Cosmetic ApplicationsYong Chool Boo0Department of Molecular Medicine, School of Medicine, Kyungpook National University, Daegu 41944, KoreaAntioxidants are deemed useful in controlling oxidative stress associated with extrinsic skin aging and pigmentation disorders. Resveratrol is a polyphenol compound found in many edible plants such as <i>Vitis vinifera</i>, and its inhibitory effects on the catalytic activity, gene expression, and posttranslational modifications of tyrosinase, a key enzyme in the melanin biosynthetic pathway, provide a mechanistic basis for its antimelanogenic effects seen in melanocytic cells, three-dimensionally reconstituted skin models, and in vivo animal models. As a potent antioxidant and a modulator of nuclear factor erythroid 2-related factor 2 (Nrf2), and sirtuin 1, resveratrol can also regulate multiple signaling pathways associated with inflammation and premature aging. Recent clinical studies have supported the efficacy of resveratrol and its analogs, such as resveratryl triacetate (RTA) and resveratryl triglycolate (RTG), in human skin lightening and antiaging. These findings suggest that resveratrol and its analogs are potentially useful as skin lightening and antiaging agents in cosmetics.https://www.mdpi.com/2076-3921/8/9/332resveratrolcosmeticsskin lighteningmelaninhypopigmentationdietary antioxidantsoxidative stressdepigmenting agentskin agingphytochemical |
| spellingShingle | Yong Chool Boo Human Skin Lightening Efficacy of Resveratrol and Its Analogs: From in Vitro Studies to Cosmetic Applications Antioxidants resveratrol cosmetics skin lightening melanin hypopigmentation dietary antioxidants oxidative stress depigmenting agent skin aging phytochemical |
| title | Human Skin Lightening Efficacy of Resveratrol and Its Analogs: From in Vitro Studies to Cosmetic Applications |
| title_full | Human Skin Lightening Efficacy of Resveratrol and Its Analogs: From in Vitro Studies to Cosmetic Applications |
| title_fullStr | Human Skin Lightening Efficacy of Resveratrol and Its Analogs: From in Vitro Studies to Cosmetic Applications |
| title_full_unstemmed | Human Skin Lightening Efficacy of Resveratrol and Its Analogs: From in Vitro Studies to Cosmetic Applications |
| title_short | Human Skin Lightening Efficacy of Resveratrol and Its Analogs: From in Vitro Studies to Cosmetic Applications |
| title_sort | human skin lightening efficacy of resveratrol and its analogs from in vitro studies to cosmetic applications |
| topic | resveratrol cosmetics skin lightening melanin hypopigmentation dietary antioxidants oxidative stress depigmenting agent skin aging phytochemical |
| url | https://www.mdpi.com/2076-3921/8/9/332 |
| work_keys_str_mv | AT yongchoolboo humanskinlighteningefficacyofresveratrolanditsanalogsfrominvitrostudiestocosmeticapplications |