Biocompatible organic–inorganic hybrid materials based on nucleobases and titanium developed by molecular layer deposition
We have constructed thin films of organic–inorganic hybrid character by combining titanium tetra-isopropoxide (TTIP) and the nucleobases thymine, uracil or adenine using the molecular layer deposition (MLD) approach. Such materials have potential as bioactive coatings, and the bioactivity of these f...
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| Format: | Article |
| Language: | English |
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Beilstein-Institut
2019-02-01
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| Series: | Beilstein Journal of Nanotechnology |
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| Online Access: | https://doi.org/10.3762/bjnano.10.39 |
| _version_ | 1811235908606754816 |
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| author | Leva Momtazi Henrik H. Sønsteby Ola Nilsen |
| author_facet | Leva Momtazi Henrik H. Sønsteby Ola Nilsen |
| author_sort | Leva Momtazi |
| collection | DOAJ |
| description | We have constructed thin films of organic–inorganic hybrid character by combining titanium tetra-isopropoxide (TTIP) and the nucleobases thymine, uracil or adenine using the molecular layer deposition (MLD) approach. Such materials have potential as bioactive coatings, and the bioactivity of these films is described in our recent work [Momtazi, L.; Dartt, D. A.; Nilsen, O.; Eidet, J. R. J. Biomed. Mater. Res., Part A 2018, 106, 3090–3098. doi:10.1002/jbm.a.36499]. The growth was followed by in situ quartz crystal microbalance (QCM) measurements and all systems exhibited atomic layer deposition (ALD) type of growth. The adenine system has an ALD temperature window between 250 and 300 °C, while an overall reduction in growth rate with increasing temperature was observed for the uracil and thymine systems. The bonding modes of the films have been further characterized by Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy and X-ray diffraction, confirming the hybrid nature of the as-deposited films with an amorphous structure where partial inclusion of the TTIP molecule occurs during growth. The films are highly hydrophilic, while the nucleobases do leach in water providing an amorphous structure mainly of TiO2 with reduced density and index of refraction. |
| first_indexed | 2024-04-12T11:59:54Z |
| format | Article |
| id | doaj.art-11f2216a64984be0a1b01e7d840db490 |
| institution | Directory Open Access Journal |
| issn | 2190-4286 |
| language | English |
| last_indexed | 2024-04-12T11:59:54Z |
| publishDate | 2019-02-01 |
| publisher | Beilstein-Institut |
| record_format | Article |
| series | Beilstein Journal of Nanotechnology |
| spelling | doaj.art-11f2216a64984be0a1b01e7d840db4902022-12-22T03:33:53ZengBeilstein-InstitutBeilstein Journal of Nanotechnology2190-42862019-02-0110139941110.3762/bjnano.10.392190-4286-10-39Biocompatible organic–inorganic hybrid materials based on nucleobases and titanium developed by molecular layer depositionLeva Momtazi0Henrik H. Sønsteby1Ola Nilsen2Centre for Materials Science and Nanotechnology (SMN), Department of Chemistry, University of Oslo, P.O. Box 1033 Blindern, N-0315 Oslo, NorwayCentre for Materials Science and Nanotechnology (SMN), Department of Chemistry, University of Oslo, P.O. Box 1033 Blindern, N-0315 Oslo, NorwayCentre for Materials Science and Nanotechnology (SMN), Department of Chemistry, University of Oslo, P.O. Box 1033 Blindern, N-0315 Oslo, NorwayWe have constructed thin films of organic–inorganic hybrid character by combining titanium tetra-isopropoxide (TTIP) and the nucleobases thymine, uracil or adenine using the molecular layer deposition (MLD) approach. Such materials have potential as bioactive coatings, and the bioactivity of these films is described in our recent work [Momtazi, L.; Dartt, D. A.; Nilsen, O.; Eidet, J. R. J. Biomed. Mater. Res., Part A 2018, 106, 3090–3098. doi:10.1002/jbm.a.36499]. The growth was followed by in situ quartz crystal microbalance (QCM) measurements and all systems exhibited atomic layer deposition (ALD) type of growth. The adenine system has an ALD temperature window between 250 and 300 °C, while an overall reduction in growth rate with increasing temperature was observed for the uracil and thymine systems. The bonding modes of the films have been further characterized by Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy and X-ray diffraction, confirming the hybrid nature of the as-deposited films with an amorphous structure where partial inclusion of the TTIP molecule occurs during growth. The films are highly hydrophilic, while the nucleobases do leach in water providing an amorphous structure mainly of TiO2 with reduced density and index of refraction.https://doi.org/10.3762/bjnano.10.39ALDbioactive materialshybrid materialsMLDnucleobases |
| spellingShingle | Leva Momtazi Henrik H. Sønsteby Ola Nilsen Biocompatible organic–inorganic hybrid materials based on nucleobases and titanium developed by molecular layer deposition Beilstein Journal of Nanotechnology ALD bioactive materials hybrid materials MLD nucleobases |
| title | Biocompatible organic–inorganic hybrid materials based on nucleobases and titanium developed by molecular layer deposition |
| title_full | Biocompatible organic–inorganic hybrid materials based on nucleobases and titanium developed by molecular layer deposition |
| title_fullStr | Biocompatible organic–inorganic hybrid materials based on nucleobases and titanium developed by molecular layer deposition |
| title_full_unstemmed | Biocompatible organic–inorganic hybrid materials based on nucleobases and titanium developed by molecular layer deposition |
| title_short | Biocompatible organic–inorganic hybrid materials based on nucleobases and titanium developed by molecular layer deposition |
| title_sort | biocompatible organic inorganic hybrid materials based on nucleobases and titanium developed by molecular layer deposition |
| topic | ALD bioactive materials hybrid materials MLD nucleobases |
| url | https://doi.org/10.3762/bjnano.10.39 |
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