Vitamin C-induced oxalate nephropathy in a renal transplant patient related to excessive ingestion of cashew pseudofruit (Anacardium occidentale L.): a case report
Abstract Background Ingestion of vitamin C is generally regarded as harmless. Oxalate nephropathy is an infrequent condition and is characterized by oxalate deposition in the renal tubules, in some cases resulting in acute kidney injury. It can be caused by overproduction of oxalate in genetic disor...
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| Format: | Article |
| Language: | English |
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BMC
2018-10-01
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| Series: | BMC Nephrology |
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| Online Access: | http://link.springer.com/article/10.1186/s12882-018-1060-9 |
| _version_ | 1819149091709386752 |
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| author | Miguel Moyses-Neto Bruno Rafael Santos Brito Dyego José de Araújo Brito Noelia Dias Carneiro Barros Márcio Dantas Natalino Salgado-Filho Roberto Silva Costa Gyl Eanes Barros Silva |
| author_facet | Miguel Moyses-Neto Bruno Rafael Santos Brito Dyego José de Araújo Brito Noelia Dias Carneiro Barros Márcio Dantas Natalino Salgado-Filho Roberto Silva Costa Gyl Eanes Barros Silva |
| author_sort | Miguel Moyses-Neto |
| collection | DOAJ |
| description | Abstract Background Ingestion of vitamin C is generally regarded as harmless. Oxalate nephropathy is an infrequent condition and is characterized by oxalate deposition in the renal tubules, in some cases resulting in acute kidney injury. It can be caused by overproduction of oxalate in genetic disorders and, more frequently, as a secondary phenomenon provoked by ingestion of oxalate or substances that can be transformed into oxalate in the patient. Case presentation We present a case of acute oxalate nephropathy in a 59-year-old black male with type 2 diabetes mellitus, who received a kidney transplant 11 years prior. He ingested a large amount of cashew pseudofruit (“cashew apple”) during 1 month and developed acute kidney injury. His previous blood creatinine was 2.0 mg/dL, which increased to 7.2 mg/d; he required hemodialysis. He was subsequently discharged without need for dialysis; 3 months later his blood creatinine stabilized at 3.6 mg/dL. Conclusions This pseudofruit is rich in ascorbic acid (vitamin C) and poor in oxalate. Urinary oxalate excretion begins to increase when amounts of ascorbic acid above bodily requirements are ingested, and may provoke acute oxalate nephropathy. The patient’s oxalate acute nephropathy, in this case, was attributed to excessive vitamin C ingestion from the cashew pseudofruit associated with decreased renal function. |
| first_indexed | 2024-12-22T13:56:06Z |
| format | Article |
| id | doaj.art-11f223ec58304a34a8e611befbd2a25c |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-12-22T13:56:06Z |
| publishDate | 2018-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-11f223ec58304a34a8e611befbd2a25c2022-12-21T18:23:32ZengBMCBMC Nephrology1471-23692018-10-011911410.1186/s12882-018-1060-9Vitamin C-induced oxalate nephropathy in a renal transplant patient related to excessive ingestion of cashew pseudofruit (Anacardium occidentale L.): a case reportMiguel Moyses-Neto0Bruno Rafael Santos Brito1Dyego José de Araújo Brito2Noelia Dias Carneiro Barros3Márcio Dantas4Natalino Salgado-Filho5Roberto Silva Costa6Gyl Eanes Barros Silva7Nephrology Division, Department of Internal Medicine, Ribeirão Preto Medical School, University of São PauloKidney Disease Prevention Centre and University Hospital, Federal University of MaranhãoKidney Disease Prevention Centre and University Hospital, Federal University of MaranhãoKidney Disease Prevention Centre and University Hospital, Federal University of MaranhãoNephrology Division, Department of Internal Medicine, Ribeirão Preto Medical School, University of São PauloKidney Disease Prevention Centre and University Hospital, Federal University of MaranhãoDepartment of Pathology, Ribeirão Preto Medical School, University of São PauloKidney Disease Prevention Centre and University Hospital, Federal University of MaranhãoAbstract Background Ingestion of vitamin C is generally regarded as harmless. Oxalate nephropathy is an infrequent condition and is characterized by oxalate deposition in the renal tubules, in some cases resulting in acute kidney injury. It can be caused by overproduction of oxalate in genetic disorders and, more frequently, as a secondary phenomenon provoked by ingestion of oxalate or substances that can be transformed into oxalate in the patient. Case presentation We present a case of acute oxalate nephropathy in a 59-year-old black male with type 2 diabetes mellitus, who received a kidney transplant 11 years prior. He ingested a large amount of cashew pseudofruit (“cashew apple”) during 1 month and developed acute kidney injury. His previous blood creatinine was 2.0 mg/dL, which increased to 7.2 mg/d; he required hemodialysis. He was subsequently discharged without need for dialysis; 3 months later his blood creatinine stabilized at 3.6 mg/dL. Conclusions This pseudofruit is rich in ascorbic acid (vitamin C) and poor in oxalate. Urinary oxalate excretion begins to increase when amounts of ascorbic acid above bodily requirements are ingested, and may provoke acute oxalate nephropathy. The patient’s oxalate acute nephropathy, in this case, was attributed to excessive vitamin C ingestion from the cashew pseudofruit associated with decreased renal function.http://link.springer.com/article/10.1186/s12882-018-1060-9Ascorbic acidCashew pseudofruitRenal functionDialysisAcute kidney injuryOxalate nephropathy |
| spellingShingle | Miguel Moyses-Neto Bruno Rafael Santos Brito Dyego José de Araújo Brito Noelia Dias Carneiro Barros Márcio Dantas Natalino Salgado-Filho Roberto Silva Costa Gyl Eanes Barros Silva Vitamin C-induced oxalate nephropathy in a renal transplant patient related to excessive ingestion of cashew pseudofruit (Anacardium occidentale L.): a case report BMC Nephrology Ascorbic acid Cashew pseudofruit Renal function Dialysis Acute kidney injury Oxalate nephropathy |
| title | Vitamin C-induced oxalate nephropathy in a renal transplant patient related to excessive ingestion of cashew pseudofruit (Anacardium occidentale L.): a case report |
| title_full | Vitamin C-induced oxalate nephropathy in a renal transplant patient related to excessive ingestion of cashew pseudofruit (Anacardium occidentale L.): a case report |
| title_fullStr | Vitamin C-induced oxalate nephropathy in a renal transplant patient related to excessive ingestion of cashew pseudofruit (Anacardium occidentale L.): a case report |
| title_full_unstemmed | Vitamin C-induced oxalate nephropathy in a renal transplant patient related to excessive ingestion of cashew pseudofruit (Anacardium occidentale L.): a case report |
| title_short | Vitamin C-induced oxalate nephropathy in a renal transplant patient related to excessive ingestion of cashew pseudofruit (Anacardium occidentale L.): a case report |
| title_sort | vitamin c induced oxalate nephropathy in a renal transplant patient related to excessive ingestion of cashew pseudofruit anacardium occidentale l a case report |
| topic | Ascorbic acid Cashew pseudofruit Renal function Dialysis Acute kidney injury Oxalate nephropathy |
| url | http://link.springer.com/article/10.1186/s12882-018-1060-9 |
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