Predictive Value of HFA-PEFF Score in Patients With Heart Failure With Preserved Ejection Fraction
Aims: HFA-PEFF score has been proposed for diagnosing heart failure with preserved ejection fraction (HFpEF). Currently, there are only a limited number of tools for predicting the prognosis. In this study, we evaluated whether the HFA-PEFF score can predict mortality in patients with HFpEF.Methods:...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-10-01
|
| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2021.656536/full |
| _version_ | 1819144316921053184 |
|---|---|
| author | Yuxi Sun Jinping Si Jiaxin Li Mengyuan Dai Emma King Xinxin Zhang Yanli Zhang Yunlong Xia Gary Tse Gary Tse Gary Tse Ying Liu |
| author_facet | Yuxi Sun Jinping Si Jiaxin Li Mengyuan Dai Emma King Xinxin Zhang Yanli Zhang Yunlong Xia Gary Tse Gary Tse Gary Tse Ying Liu |
| author_sort | Yuxi Sun |
| collection | DOAJ |
| description | Aims: HFA-PEFF score has been proposed for diagnosing heart failure with preserved ejection fraction (HFpEF). Currently, there are only a limited number of tools for predicting the prognosis. In this study, we evaluated whether the HFA-PEFF score can predict mortality in patients with HFpEF.Methods: This single-center, retrospective observational study enrolled patients diagnosed with HFpEF at the First Affiliated Hospital of Dalian Medical University between January 1, 2015, and April 30, 2018. The subjects were divided according to their HFA-PEFF score into low (0–2 points), intermediate (3–4 points), and high (5–6 points) score groups. The primary outcome was all-cause mortality.Results: A total of 358 patients (mean age: 70.21 ± 8.64 years, 58.1% female) were included. Of these, 63 (17.6%), 156 (43.6%), and 139 (38.8%) were classified into the low, intermediate, and high score groups, respectively. Over a mean follow-up of 26.9 months, 46 patients (12.8%) died. The percentage of patients who died in the low, intermediate, and high score groups were 1 (1.6%), 18 (11.5%), and 27 (19.4%), respectively. A multivariate Cox regression identified HFA-PEFF score as an independent predictor of all-cause mortality [hazard ratio (HR):1.314, 95% CI: 1.013–1.705, P = 0.039]. A Cox analysis demonstrated a significantly higher rate of mortality in the intermediate (HR: 4.912, 95% CI 1.154–20.907, P = 0.031) and high score groups (HR: 5.291, 95% CI: 1.239–22.593, P = 0.024) than the low score group. A receiver operating characteristic (ROC) analysis indicated that the HFA-PEFF score can effectively predict all-cause mortality after adjusting for age and New York Heart Association (NYHA) class [area under the curve (AUC) 0.726, 95% CI 0.651–0.800, P = 0.000]. With an HFA-PEFF score cut-off value of 3.5, the sensitivity and specificity were 78.3 and 54.8%, respectively. The AUC on ROC analysis for the biomarker component of the score was similar to that of the total score.Conclusions: The HFA-PEFF score can be used both to diagnose HFpEF and predict the prognosis. The higher scores are associated with higher all-cause mortality. |
| first_indexed | 2024-12-22T12:40:12Z |
| format | Article |
| id | doaj.art-11f53d2cc94b4fbebbd2f120f3e32f40 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-12-22T12:40:12Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-11f53d2cc94b4fbebbd2f120f3e32f402022-12-21T18:25:28ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2021-10-01810.3389/fcvm.2021.656536656536Predictive Value of HFA-PEFF Score in Patients With Heart Failure With Preserved Ejection FractionYuxi Sun0Jinping Si1Jiaxin Li2Mengyuan Dai3Emma King4Xinxin Zhang5Yanli Zhang6Yunlong Xia7Gary Tse8Gary Tse9Gary Tse10Ying Liu11Heart Failure and Structural Cardiology Ward, First Affiliated Hospital of Dalian Medical University, Dalian, ChinaHeart Failure and Structural Cardiology Ward, First Affiliated Hospital of Dalian Medical University, Dalian, ChinaHeart Failure and Structural Cardiology Ward, First Affiliated Hospital of Dalian Medical University, Dalian, ChinaHeart Failure and Structural Cardiology Ward, First Affiliated Hospital of Dalian Medical University, Dalian, ChinaCardiovascular Analytics Group, Hong Kong SAR, ChinaHeart Failure and Structural Cardiology Ward, First Affiliated Hospital of Dalian Medical University, Dalian, ChinaHeart Failure and Structural Cardiology Ward, First Affiliated Hospital of Dalian Medical University, Dalian, ChinaHeart Failure and Structural Cardiology Ward, First Affiliated Hospital of Dalian Medical University, Dalian, ChinaHeart Failure and Structural Cardiology Ward, First Affiliated Hospital of Dalian Medical University, Dalian, ChinaCardiovascular Analytics Group, Hong Kong SAR, ChinaKent and Medway Medical School, Canterbury, United KingdomHeart Failure and Structural Cardiology Ward, First Affiliated Hospital of Dalian Medical University, Dalian, ChinaAims: HFA-PEFF score has been proposed for diagnosing heart failure with preserved ejection fraction (HFpEF). Currently, there are only a limited number of tools for predicting the prognosis. In this study, we evaluated whether the HFA-PEFF score can predict mortality in patients with HFpEF.Methods: This single-center, retrospective observational study enrolled patients diagnosed with HFpEF at the First Affiliated Hospital of Dalian Medical University between January 1, 2015, and April 30, 2018. The subjects were divided according to their HFA-PEFF score into low (0–2 points), intermediate (3–4 points), and high (5–6 points) score groups. The primary outcome was all-cause mortality.Results: A total of 358 patients (mean age: 70.21 ± 8.64 years, 58.1% female) were included. Of these, 63 (17.6%), 156 (43.6%), and 139 (38.8%) were classified into the low, intermediate, and high score groups, respectively. Over a mean follow-up of 26.9 months, 46 patients (12.8%) died. The percentage of patients who died in the low, intermediate, and high score groups were 1 (1.6%), 18 (11.5%), and 27 (19.4%), respectively. A multivariate Cox regression identified HFA-PEFF score as an independent predictor of all-cause mortality [hazard ratio (HR):1.314, 95% CI: 1.013–1.705, P = 0.039]. A Cox analysis demonstrated a significantly higher rate of mortality in the intermediate (HR: 4.912, 95% CI 1.154–20.907, P = 0.031) and high score groups (HR: 5.291, 95% CI: 1.239–22.593, P = 0.024) than the low score group. A receiver operating characteristic (ROC) analysis indicated that the HFA-PEFF score can effectively predict all-cause mortality after adjusting for age and New York Heart Association (NYHA) class [area under the curve (AUC) 0.726, 95% CI 0.651–0.800, P = 0.000]. With an HFA-PEFF score cut-off value of 3.5, the sensitivity and specificity were 78.3 and 54.8%, respectively. The AUC on ROC analysis for the biomarker component of the score was similar to that of the total score.Conclusions: The HFA-PEFF score can be used both to diagnose HFpEF and predict the prognosis. The higher scores are associated with higher all-cause mortality.https://www.frontiersin.org/articles/10.3389/fcvm.2021.656536/fullpredictive valueall-cause mortalityHFpEFHFA-PEFF scoreprognosis |
| spellingShingle | Yuxi Sun Jinping Si Jiaxin Li Mengyuan Dai Emma King Xinxin Zhang Yanli Zhang Yunlong Xia Gary Tse Gary Tse Gary Tse Ying Liu Predictive Value of HFA-PEFF Score in Patients With Heart Failure With Preserved Ejection Fraction Frontiers in Cardiovascular Medicine predictive value all-cause mortality HFpEF HFA-PEFF score prognosis |
| title | Predictive Value of HFA-PEFF Score in Patients With Heart Failure With Preserved Ejection Fraction |
| title_full | Predictive Value of HFA-PEFF Score in Patients With Heart Failure With Preserved Ejection Fraction |
| title_fullStr | Predictive Value of HFA-PEFF Score in Patients With Heart Failure With Preserved Ejection Fraction |
| title_full_unstemmed | Predictive Value of HFA-PEFF Score in Patients With Heart Failure With Preserved Ejection Fraction |
| title_short | Predictive Value of HFA-PEFF Score in Patients With Heart Failure With Preserved Ejection Fraction |
| title_sort | predictive value of hfa peff score in patients with heart failure with preserved ejection fraction |
| topic | predictive value all-cause mortality HFpEF HFA-PEFF score prognosis |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2021.656536/full |
| work_keys_str_mv | AT yuxisun predictivevalueofhfapeffscoreinpatientswithheartfailurewithpreservedejectionfraction AT jinpingsi predictivevalueofhfapeffscoreinpatientswithheartfailurewithpreservedejectionfraction AT jiaxinli predictivevalueofhfapeffscoreinpatientswithheartfailurewithpreservedejectionfraction AT mengyuandai predictivevalueofhfapeffscoreinpatientswithheartfailurewithpreservedejectionfraction AT emmaking predictivevalueofhfapeffscoreinpatientswithheartfailurewithpreservedejectionfraction AT xinxinzhang predictivevalueofhfapeffscoreinpatientswithheartfailurewithpreservedejectionfraction AT yanlizhang predictivevalueofhfapeffscoreinpatientswithheartfailurewithpreservedejectionfraction AT yunlongxia predictivevalueofhfapeffscoreinpatientswithheartfailurewithpreservedejectionfraction AT garytse predictivevalueofhfapeffscoreinpatientswithheartfailurewithpreservedejectionfraction AT garytse predictivevalueofhfapeffscoreinpatientswithheartfailurewithpreservedejectionfraction AT garytse predictivevalueofhfapeffscoreinpatientswithheartfailurewithpreservedejectionfraction AT yingliu predictivevalueofhfapeffscoreinpatientswithheartfailurewithpreservedejectionfraction |