UJI AKTIVITAS EKSTRAK ETANOL BIJI PETAI CHINA (Leucaena leucocephala) TERHADAP PENURUNAN KADAR GLUKOSA DARAH PADA MENCIT PUTIH JANTAN YANG DIINDUKSI GLUKOSA
Diabetes mellitus (DM) is a metabolic disease characterized by elevated blood glucose levels due to impairment of insulin secretion, insulin work or both. Seed chinese petai (Leucaena leucochepala) is believed to be a community of medicinal plants capable of treating DM. This study aims to determine...
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| Format: | Article |
| Language: | English |
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Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin
2018-03-01
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| Series: | JIIS: Jurnal Ilmiah Ibnu Sina |
| Subjects: | |
| Online Access: | http://jiis.akfar-isfibjm.ac.id/index.php/JIIS/article/view/136/123 |
| _version_ | 1811323853482229760 |
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| author | Ratih Pratiwi Sari Aditya Maulana Perdana Putra |
| author_facet | Ratih Pratiwi Sari Aditya Maulana Perdana Putra |
| author_sort | Ratih Pratiwi Sari |
| collection | DOAJ |
| description | Diabetes mellitus (DM) is a metabolic disease characterized by elevated blood glucose levels due to impairment of insulin secretion, insulin work or both. Seed chinese petai (Leucaena leucochepala) is believed to be a community of medicinal plants capable of treating DM. This study aims to determine whether the chrysanthemum ethanol extract of china can lower blood glucose levels of mice and get the optimal dose of chrysanthemum seed ethanol extract that can be used to lower blood glucose levels of glucose-induced white glucose (Mus musculus).
The subjects of the study were male white mouse 25 divided into 5 groups, consisting of group 1 given metformin 90mg / kgBW, group 2, 3, 4 given chrysanthemum seed extract with dose 125mg / kgBW, 250mg / kgBW and 500mg / KgBW and group of 5 given aquadest 0,5ml / 20gramBW. Whole group induced glucose with dose 2gr / kgBW causing male white mouse in hyperglycemic state. Blood glucose examination at minute 0, 15, 45 and 60.
The results showed that the group given ethanol extract seed chinese petai with dose of 500mg/kgBW can decrease the blood glucose level of male white mouse significantly. The significance value in the GLM test obtained was 0.001 (P <0.05) with a mean glucose level of 114.120mg/dL. It shows that the ethanol extract seed chinese petai a can lower blood glucose level. |
| first_indexed | 2024-04-13T14:02:49Z |
| format | Article |
| id | doaj.art-11f57fa66617427588422fb816998cd1 |
| institution | Directory Open Access Journal |
| issn | 2502-647X 2503-1902 |
| language | English |
| last_indexed | 2024-04-13T14:02:49Z |
| publishDate | 2018-03-01 |
| publisher | Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin |
| record_format | Article |
| series | JIIS: Jurnal Ilmiah Ibnu Sina |
| spelling | doaj.art-11f57fa66617427588422fb816998cd12022-12-22T02:43:59ZengSekolah Tinggi Ilmu Kesehatan ISFI BanjarmasinJIIS: Jurnal Ilmiah Ibnu Sina2502-647X2503-19022018-03-01313744UJI AKTIVITAS EKSTRAK ETANOL BIJI PETAI CHINA (Leucaena leucocephala) TERHADAP PENURUNAN KADAR GLUKOSA DARAH PADA MENCIT PUTIH JANTAN YANG DIINDUKSI GLUKOSARatih Pratiwi Sari0Aditya Maulana Perdana Putra1Akademi Farmasi ISFI BanjarmasinAkademi Farmasi ISFI BanjarmasinDiabetes mellitus (DM) is a metabolic disease characterized by elevated blood glucose levels due to impairment of insulin secretion, insulin work or both. Seed chinese petai (Leucaena leucochepala) is believed to be a community of medicinal plants capable of treating DM. This study aims to determine whether the chrysanthemum ethanol extract of china can lower blood glucose levels of mice and get the optimal dose of chrysanthemum seed ethanol extract that can be used to lower blood glucose levels of glucose-induced white glucose (Mus musculus). The subjects of the study were male white mouse 25 divided into 5 groups, consisting of group 1 given metformin 90mg / kgBW, group 2, 3, 4 given chrysanthemum seed extract with dose 125mg / kgBW, 250mg / kgBW and 500mg / KgBW and group of 5 given aquadest 0,5ml / 20gramBW. Whole group induced glucose with dose 2gr / kgBW causing male white mouse in hyperglycemic state. Blood glucose examination at minute 0, 15, 45 and 60. The results showed that the group given ethanol extract seed chinese petai with dose of 500mg/kgBW can decrease the blood glucose level of male white mouse significantly. The significance value in the GLM test obtained was 0.001 (P <0.05) with a mean glucose level of 114.120mg/dL. It shows that the ethanol extract seed chinese petai a can lower blood glucose level.http://jiis.akfar-isfibjm.ac.id/index.php/JIIS/article/view/136/123Ethanol extract seed chinese petaiblood glucose levelinduction of glucose |
| spellingShingle | Ratih Pratiwi Sari Aditya Maulana Perdana Putra UJI AKTIVITAS EKSTRAK ETANOL BIJI PETAI CHINA (Leucaena leucocephala) TERHADAP PENURUNAN KADAR GLUKOSA DARAH PADA MENCIT PUTIH JANTAN YANG DIINDUKSI GLUKOSA JIIS: Jurnal Ilmiah Ibnu Sina Ethanol extract seed chinese petai blood glucose level induction of glucose |
| title | UJI AKTIVITAS EKSTRAK ETANOL BIJI PETAI CHINA (Leucaena leucocephala) TERHADAP PENURUNAN KADAR GLUKOSA DARAH PADA MENCIT PUTIH JANTAN YANG DIINDUKSI GLUKOSA |
| title_full | UJI AKTIVITAS EKSTRAK ETANOL BIJI PETAI CHINA (Leucaena leucocephala) TERHADAP PENURUNAN KADAR GLUKOSA DARAH PADA MENCIT PUTIH JANTAN YANG DIINDUKSI GLUKOSA |
| title_fullStr | UJI AKTIVITAS EKSTRAK ETANOL BIJI PETAI CHINA (Leucaena leucocephala) TERHADAP PENURUNAN KADAR GLUKOSA DARAH PADA MENCIT PUTIH JANTAN YANG DIINDUKSI GLUKOSA |
| title_full_unstemmed | UJI AKTIVITAS EKSTRAK ETANOL BIJI PETAI CHINA (Leucaena leucocephala) TERHADAP PENURUNAN KADAR GLUKOSA DARAH PADA MENCIT PUTIH JANTAN YANG DIINDUKSI GLUKOSA |
| title_short | UJI AKTIVITAS EKSTRAK ETANOL BIJI PETAI CHINA (Leucaena leucocephala) TERHADAP PENURUNAN KADAR GLUKOSA DARAH PADA MENCIT PUTIH JANTAN YANG DIINDUKSI GLUKOSA |
| title_sort | uji aktivitas ekstrak etanol biji petai china leucaena leucocephala terhadap penurunan kadar glukosa darah pada mencit putih jantan yang diinduksi glukosa |
| topic | Ethanol extract seed chinese petai blood glucose level induction of glucose |
| url | http://jiis.akfar-isfibjm.ac.id/index.php/JIIS/article/view/136/123 |
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