Senescent Microglia: The Key to the Ageing Brain?
Ageing represents the single biggest risk factor for development of neurodegenerative disease. Despite being such long-lived cells, microglia have been relatively understudied for their role in the ageing process. Reliably identifying aged microglia has proven challenging, not least due to the diver...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-04-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/9/4402 |
| _version_ | 1797536627260653568 |
|---|---|
| author | Eleanor K. Greenwood David R. Brown |
| author_facet | Eleanor K. Greenwood David R. Brown |
| author_sort | Eleanor K. Greenwood |
| collection | DOAJ |
| description | Ageing represents the single biggest risk factor for development of neurodegenerative disease. Despite being such long-lived cells, microglia have been relatively understudied for their role in the ageing process. Reliably identifying aged microglia has proven challenging, not least due to the diversity of cell populations, and the limitations of available models, further complicated by differences between human and rodent cells. Consequently, the literature contains multiple descriptions and categorisations of microglia with neurotoxic phenotypes, including senescence, without any unifying markers. The role of microglia in brain homeostasis, particularly iron storage and metabolism, may provide a key to reliable identification. |
| first_indexed | 2024-03-10T12:03:27Z |
| format | Article |
| id | doaj.art-11f5c542d0f842e987155b5439e7b058 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T12:03:27Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-11f5c542d0f842e987155b5439e7b0582023-11-21T16:45:17ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-04-01229440210.3390/ijms22094402Senescent Microglia: The Key to the Ageing Brain?Eleanor K. Greenwood0David R. Brown1Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UKDepartment of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UKAgeing represents the single biggest risk factor for development of neurodegenerative disease. Despite being such long-lived cells, microglia have been relatively understudied for their role in the ageing process. Reliably identifying aged microglia has proven challenging, not least due to the diversity of cell populations, and the limitations of available models, further complicated by differences between human and rodent cells. Consequently, the literature contains multiple descriptions and categorisations of microglia with neurotoxic phenotypes, including senescence, without any unifying markers. The role of microglia in brain homeostasis, particularly iron storage and metabolism, may provide a key to reliable identification.https://www.mdpi.com/1422-0067/22/9/4402microgliasenescenceironageingneurodegenerationSenescence Associated Secretory Phenotype |
| spellingShingle | Eleanor K. Greenwood David R. Brown Senescent Microglia: The Key to the Ageing Brain? International Journal of Molecular Sciences microglia senescence iron ageing neurodegeneration Senescence Associated Secretory Phenotype |
| title | Senescent Microglia: The Key to the Ageing Brain? |
| title_full | Senescent Microglia: The Key to the Ageing Brain? |
| title_fullStr | Senescent Microglia: The Key to the Ageing Brain? |
| title_full_unstemmed | Senescent Microglia: The Key to the Ageing Brain? |
| title_short | Senescent Microglia: The Key to the Ageing Brain? |
| title_sort | senescent microglia the key to the ageing brain |
| topic | microglia senescence iron ageing neurodegeneration Senescence Associated Secretory Phenotype |
| url | https://www.mdpi.com/1422-0067/22/9/4402 |
| work_keys_str_mv | AT eleanorkgreenwood senescentmicrogliathekeytotheageingbrain AT davidrbrown senescentmicrogliathekeytotheageingbrain |