Novel CTRP8‐RXFP1‐JAK3‐STAT3 axis promotes Cdc42‐dependent actin remodeling for enhanced filopodia formation and motility in human glioblastoma cells

Novel CTRP8‐RXFP1‐JAK3‐STAT3 axis promotes Cdc42‐dependent actin remodeling for enhanced filopodia formation and motility in human glioblastoma cells

C1q tumor necrosis factor‐related peptide 8 (CTRP8) is the least studied member of the C1Q‐TNF‐related peptide family. We identified CTRP8 as a ligand of the G protein‐coupled receptor relaxin family peptide receptor 1 (RXFP1) in glioblastoma multiforme (GBM). The CTRP8‐RXFP1 ligand–receptor system...

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Bibliographic Details
Main Authors:	Aleksandra Glogowska, Thatchawan Thanasupawat, Jason Beiko, Marshall Pitz, Sabine Hombach‐Klonisch, Thomas Klonisch
Format:	Article
Language:	English
Published:	Wiley 2022-01-01
Series:	Molecular Oncology
Subjects:	actin remodeling Cdc42 CTRP8 glioblastoma relaxin RXFP1
Online Access:	https://doi.org/10.1002/1878-0261.12981

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