Postmortem Toxicology of Tadalafil in a Forensic Case
Tadalafil is an inhibitor of the enzyme human cyclic guanosine monophosphate–specific phosphodiesterase, type 5 (PDE-5). A mild vasodilator, it is primarily used for the treatment of erectile dysfunction (ED), an increasingly common condition. Other clinical uses include benign prostatic hyperplasia...
| Hoofdauteurs: | , , |
|---|---|
| Formaat: | Artikel |
| Taal: | English |
| Gepubliceerd in: |
Shaheed Beheshti University of Medical Sciences
2023-01-01
|
| Reeks: | International Journal of Medical Toxicology and Forensic Medicine |
| Onderwerpen: | |
| Online toegang: | https://journals.sbmu.ac.ir/ijmtfm/article/view/40058/32168 |
| _version_ | 1827800212458962944 |
|---|---|
| author | Maria Laura Schirripa Letizia Gnetti Edda Emanuela Guareschi |
| author_facet | Maria Laura Schirripa Letizia Gnetti Edda Emanuela Guareschi |
| author_sort | Maria Laura Schirripa |
| collection | DOAJ |
| description | Tadalafil is an inhibitor of the enzyme human cyclic guanosine monophosphate–specific phosphodiesterase, type 5 (PDE-5). A mild vasodilator, it is primarily used for the treatment of erectile dysfunction (ED), an increasingly common condition. Other clinical uses include benign prostatic hyperplasia and pulmonary arterial hypertension. Adverse events are rare. Absolute contraindications include serious cardiac disease. Despite the widespread use of tadalafil, very little is known about any associations with lethal cases in forensic pathology, with related post-mortem redistribution phenomena and toxicology. This study presents a forensic case with possible contribution of tadalafil to the cause of death. Furthermore, an overview of tadalafil and a discussion on its relevance in the forensic practice are discussed. The administration of tadalafil might act as a concurrent cause, or contributing factor, to lethal cardiogenic shock in subjects with cardiac disease. |
| first_indexed | 2024-03-11T20:06:08Z |
| format | Article |
| id | doaj.art-11f8b3097c204c82ba860c38cf9b3b51 |
| institution | Directory Open Access Journal |
| issn | 2251-8762 2251-8770 |
| language | English |
| last_indexed | 2024-03-11T20:06:08Z |
| publishDate | 2023-01-01 |
| publisher | Shaheed Beheshti University of Medical Sciences |
| record_format | Article |
| series | International Journal of Medical Toxicology and Forensic Medicine |
| spelling | doaj.art-11f8b3097c204c82ba860c38cf9b3b512023-10-03T17:34:10ZengShaheed Beheshti University of Medical SciencesInternational Journal of Medical Toxicology and Forensic Medicine2251-87622251-87702023-01-01133Postmortem Toxicology of Tadalafil in a Forensic CaseMaria Laura SchirripaLetizia GnettiEdda Emanuela GuareschiTadalafil is an inhibitor of the enzyme human cyclic guanosine monophosphate–specific phosphodiesterase, type 5 (PDE-5). A mild vasodilator, it is primarily used for the treatment of erectile dysfunction (ED), an increasingly common condition. Other clinical uses include benign prostatic hyperplasia and pulmonary arterial hypertension. Adverse events are rare. Absolute contraindications include serious cardiac disease. Despite the widespread use of tadalafil, very little is known about any associations with lethal cases in forensic pathology, with related post-mortem redistribution phenomena and toxicology. This study presents a forensic case with possible contribution of tadalafil to the cause of death. Furthermore, an overview of tadalafil and a discussion on its relevance in the forensic practice are discussed. The administration of tadalafil might act as a concurrent cause, or contributing factor, to lethal cardiogenic shock in subjects with cardiac disease.https://journals.sbmu.ac.ir/ijmtfm/article/view/40058/32168post-mortemtoxicologytadalafilcause of deathcardiogenic shock |
| spellingShingle | Maria Laura Schirripa Letizia Gnetti Edda Emanuela Guareschi Postmortem Toxicology of Tadalafil in a Forensic Case International Journal of Medical Toxicology and Forensic Medicine post-mortem toxicology tadalafil cause of death cardiogenic shock |
| title | Postmortem Toxicology of Tadalafil in a Forensic Case |
| title_full | Postmortem Toxicology of Tadalafil in a Forensic Case |
| title_fullStr | Postmortem Toxicology of Tadalafil in a Forensic Case |
| title_full_unstemmed | Postmortem Toxicology of Tadalafil in a Forensic Case |
| title_short | Postmortem Toxicology of Tadalafil in a Forensic Case |
| title_sort | postmortem toxicology of tadalafil in a forensic case |
| topic | post-mortem toxicology tadalafil cause of death cardiogenic shock |
| url | https://journals.sbmu.ac.ir/ijmtfm/article/view/40058/32168 |
| work_keys_str_mv | AT marialauraschirripa postmortemtoxicologyoftadalafilinaforensiccase AT letiziagnetti postmortemtoxicologyoftadalafilinaforensiccase AT eddaemanuelaguareschi postmortemtoxicologyoftadalafilinaforensiccase |