Delineation of the Direct Contribution of Candida auris ERG11 Mutations to Clinical Triazole Resistance

Delineation of the Direct Contribution of Candida auris ERG11 Mutations to Clinical Triazole Resistance

ABSTRACT Resistance to fluconazole is one of clinical characteristics most frequently challenging the treatment of invasive Candida auris infections, and is observed among >90% of all characterized clinical isolates. In this work, the native C. auris ERG11 allele in a previously characterized flu...

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Bibliographic Details
Main Authors: Jeffrey M. Rybak, Cheshta Sharma, Laura A. Doorley, Katherine S. Barker, Glen E. Palmer, P. David Rogers
Format: Article
Language:English
Published: American Society for Microbiology 2021-12-01
Series:Microbiology Spectrum
Subjects:
Candida
triazole
resistance
ERG11
CRISPR
Online Access:https://journals.asm.org/doi/10.1128/Spectrum.01585-21

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