IL-17A reprograms intestinal epithelial cells to facilitate HIV-1 replication and outgrowth in CD4+ T cells

IL-17A reprograms intestinal epithelial cells to facilitate HIV-1 replication and outgrowth in CD4+ T cells

Summary: The crosstalk between intestinal epithelial cells (IECs) and Th17-polarized CD4+ T cells is critical for mucosal homeostasis, with HIV-1 causing significant alterations in people living with HIV (PLWH) despite antiretroviral therapy (ART). In a model of IEC and T cell co-cultures, we invest...

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Bibliographic Details
Main Authors: Tomas Raul Wiche Salinas, Annie Gosselin, Laurence Raymond Marchand, Etiene Moreira Gabriel, Olivier Tastet, Jean-Philippe Goulet, Yuwei Zhang, Dragos Vlad, Hanane Touil, Jean-Pierre Routy, Mariana G. Bego, Mohamed El-Far, Nicolas Chomont, Alan L. Landay, Éric A. Cohen, Cécile Tremblay, Petronela Ancuta
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:iScience
Subjects:
Immunology
Immune response
Virology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221011937

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