The Roles of Various Prostaglandins in Fibrosis: A Review
Organ fibrosis is a common pathological result of various chronic diseases with multiple causes. Fibrosis is characterized by the excessive deposition of extracellular matrix and eventually leads to the destruction of the tissue structure and impaired organ function. Prostaglandins are produced by a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/11/6/789 |
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| author | Ke Li Jing Zhao Mingxuan Wang Lingzhi Niu Yuanping Wang Yanxia Li Yajuan Zheng |
| author_facet | Ke Li Jing Zhao Mingxuan Wang Lingzhi Niu Yuanping Wang Yanxia Li Yajuan Zheng |
| author_sort | Ke Li |
| collection | DOAJ |
| description | Organ fibrosis is a common pathological result of various chronic diseases with multiple causes. Fibrosis is characterized by the excessive deposition of extracellular matrix and eventually leads to the destruction of the tissue structure and impaired organ function. Prostaglandins are produced by arachidonic acid through cyclooxygenases and various prostaglandin-specific synthases. Prostaglandins bind to homologous receptors on adjacent tissue cells in an autocrine or paracrine manner and participate in the regulation of a series of physiological or pathological processes, including fibrosis. This review summarizes the properties, synthesis, and degradation of various prostaglandins, as well as the roles of these prostaglandins and their receptors in fibrosis in multiple models to reveal the clinical significance of prostaglandins and their receptors in the treatment of fibrosis. |
| first_indexed | 2024-03-10T11:06:03Z |
| format | Article |
| id | doaj.art-11fd64a8957b46e2888e6a5f0a5cd2fe |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T11:06:03Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-11fd64a8957b46e2888e6a5f0a5cd2fe2023-11-21T21:08:35ZengMDPI AGBiomolecules2218-273X2021-05-0111678910.3390/biom11060789The Roles of Various Prostaglandins in Fibrosis: A ReviewKe Li0Jing Zhao1Mingxuan Wang2Lingzhi Niu3Yuanping Wang4Yanxia Li5Yajuan Zheng6Department of Ophthalmology, The Second Hospital of Jilin University, Changchun 130000, ChinaDepartment of Ophthalmology, The Second Hospital of Jilin University, Changchun 130000, ChinaDepartment of Ophthalmology, The Second Hospital of Jilin University, Changchun 130000, ChinaDepartment of Ophthalmology, The Second Hospital of Jilin University, Changchun 130000, ChinaDepartment of Ophthalmology, The Second Hospital of Jilin University, Changchun 130000, ChinaDepartment of Ophthalmology, The Second Hospital of Jilin University, Changchun 130000, ChinaDepartment of Ophthalmology, The Second Hospital of Jilin University, Changchun 130000, ChinaOrgan fibrosis is a common pathological result of various chronic diseases with multiple causes. Fibrosis is characterized by the excessive deposition of extracellular matrix and eventually leads to the destruction of the tissue structure and impaired organ function. Prostaglandins are produced by arachidonic acid through cyclooxygenases and various prostaglandin-specific synthases. Prostaglandins bind to homologous receptors on adjacent tissue cells in an autocrine or paracrine manner and participate in the regulation of a series of physiological or pathological processes, including fibrosis. This review summarizes the properties, synthesis, and degradation of various prostaglandins, as well as the roles of these prostaglandins and their receptors in fibrosis in multiple models to reveal the clinical significance of prostaglandins and their receptors in the treatment of fibrosis.https://www.mdpi.com/2218-273X/11/6/789fibrosismyofibroblastPGE2PGD2PGI2PGF2α |
| spellingShingle | Ke Li Jing Zhao Mingxuan Wang Lingzhi Niu Yuanping Wang Yanxia Li Yajuan Zheng The Roles of Various Prostaglandins in Fibrosis: A Review Biomolecules fibrosis myofibroblast PGE2 PGD2 PGI2 PGF2α |
| title | The Roles of Various Prostaglandins in Fibrosis: A Review |
| title_full | The Roles of Various Prostaglandins in Fibrosis: A Review |
| title_fullStr | The Roles of Various Prostaglandins in Fibrosis: A Review |
| title_full_unstemmed | The Roles of Various Prostaglandins in Fibrosis: A Review |
| title_short | The Roles of Various Prostaglandins in Fibrosis: A Review |
| title_sort | roles of various prostaglandins in fibrosis a review |
| topic | fibrosis myofibroblast PGE2 PGD2 PGI2 PGF2α |
| url | https://www.mdpi.com/2218-273X/11/6/789 |
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