Repeatability and Reproducibility of Retinal Fractal Dimension Measured with Swept-Source Optical Coherence Tomography Angiography in Healthy Eyes: A Proof-of-Concept Study
The retinal vascular network fractal dimension (FD) could be a promising imaging biomarker. Our objective was to evaluate its repeatability and reproducibility in healthy eyes. A cross-sectional study was undertaken with young, healthy volunteers who had no reported cardiac risk factors or ocular di...
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| Format: | Article |
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MDPI AG
2022-07-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/7/1769 |
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| author | Louis Arnould Déa Haddad Florian Baudin Pierre-Henry Gabrielle Marc Sarossy Alain M. Bron Behzad Aliahmad Catherine Creuzot-Garcher |
| author_facet | Louis Arnould Déa Haddad Florian Baudin Pierre-Henry Gabrielle Marc Sarossy Alain M. Bron Behzad Aliahmad Catherine Creuzot-Garcher |
| author_sort | Louis Arnould |
| collection | DOAJ |
| description | The retinal vascular network fractal dimension (FD) could be a promising imaging biomarker. Our objective was to evaluate its repeatability and reproducibility in healthy eyes. A cross-sectional study was undertaken with young, healthy volunteers who had no reported cardiac risk factors or ocular disease history. For each participant, three SS-OCTA images (12 × 12 mm) were acquired using the Plex Elite 9000 (Carl Zeiss Meditec AG, Jena, Germany) by two ophthalmologists. Automated segmentation was obtained from both the superficial and deep capillary plexuses. FD was estimated by box counting. The intraclass correlation coefficients (ICC) were used as measures for repeatability and reproducibility. A total of 43 eyes of healthy volunteers were included. The mean ± standard deviation (SD) age was 30 ± 6.2 years. The results show good repeatability. The ICC was 0.722 (95% CI, 0.541–0.839) in the superficial capillary plexus and 0.828 (95% CI, 0.705–0.903) in the deep capillary plexus. For reproducibility, the ICC was 0.651 (95% CI, 0.439–0.795) and 0.363 (95% CI, 0.073–0.596) at the superficial and deep capillary plexus, respectively. In this study, the FD of the vascular network measured via SS-OCTA showed good repeatability and reproducibility in healthy participants. |
| first_indexed | 2024-03-09T12:00:16Z |
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| id | doaj.art-11fdafc42168419daab15b3b7a06693c |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T12:00:16Z |
| publishDate | 2022-07-01 |
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| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-11fdafc42168419daab15b3b7a06693c2023-11-30T23:04:14ZengMDPI AGDiagnostics2075-44182022-07-01127176910.3390/diagnostics12071769Repeatability and Reproducibility of Retinal Fractal Dimension Measured with Swept-Source Optical Coherence Tomography Angiography in Healthy Eyes: A Proof-of-Concept StudyLouis Arnould0Déa Haddad1Florian Baudin2Pierre-Henry Gabrielle3Marc Sarossy4Alain M. Bron5Behzad Aliahmad6Catherine Creuzot-Garcher7Ophthalmology Department, Dijon University Hospital, 21000 Dijon, FranceOphthalmology Department, Dijon University Hospital, 21000 Dijon, FranceOphthalmology Department, Dijon University Hospital, 21000 Dijon, FranceOphthalmology Department, Dijon University Hospital, 21000 Dijon, FranceSchool of Engineering, RMIT University, Melbourne, VIC 3000, AustraliaOphthalmology Department, Dijon University Hospital, 21000 Dijon, FranceSchool of Engineering, RMIT University, Melbourne, VIC 3000, AustraliaOphthalmology Department, Dijon University Hospital, 21000 Dijon, FranceThe retinal vascular network fractal dimension (FD) could be a promising imaging biomarker. Our objective was to evaluate its repeatability and reproducibility in healthy eyes. A cross-sectional study was undertaken with young, healthy volunteers who had no reported cardiac risk factors or ocular disease history. For each participant, three SS-OCTA images (12 × 12 mm) were acquired using the Plex Elite 9000 (Carl Zeiss Meditec AG, Jena, Germany) by two ophthalmologists. Automated segmentation was obtained from both the superficial and deep capillary plexuses. FD was estimated by box counting. The intraclass correlation coefficients (ICC) were used as measures for repeatability and reproducibility. A total of 43 eyes of healthy volunteers were included. The mean ± standard deviation (SD) age was 30 ± 6.2 years. The results show good repeatability. The ICC was 0.722 (95% CI, 0.541–0.839) in the superficial capillary plexus and 0.828 (95% CI, 0.705–0.903) in the deep capillary plexus. For reproducibility, the ICC was 0.651 (95% CI, 0.439–0.795) and 0.363 (95% CI, 0.073–0.596) at the superficial and deep capillary plexus, respectively. In this study, the FD of the vascular network measured via SS-OCTA showed good repeatability and reproducibility in healthy participants.https://www.mdpi.com/2075-4418/12/7/1769fractal dimensionhealthy volunteersswept-source OCT angiographysuperficial retinal capillary plexusdeep retinal capillary plexusretina |
| spellingShingle | Louis Arnould Déa Haddad Florian Baudin Pierre-Henry Gabrielle Marc Sarossy Alain M. Bron Behzad Aliahmad Catherine Creuzot-Garcher Repeatability and Reproducibility of Retinal Fractal Dimension Measured with Swept-Source Optical Coherence Tomography Angiography in Healthy Eyes: A Proof-of-Concept Study Diagnostics fractal dimension healthy volunteers swept-source OCT angiography superficial retinal capillary plexus deep retinal capillary plexus retina |
| title | Repeatability and Reproducibility of Retinal Fractal Dimension Measured with Swept-Source Optical Coherence Tomography Angiography in Healthy Eyes: A Proof-of-Concept Study |
| title_full | Repeatability and Reproducibility of Retinal Fractal Dimension Measured with Swept-Source Optical Coherence Tomography Angiography in Healthy Eyes: A Proof-of-Concept Study |
| title_fullStr | Repeatability and Reproducibility of Retinal Fractal Dimension Measured with Swept-Source Optical Coherence Tomography Angiography in Healthy Eyes: A Proof-of-Concept Study |
| title_full_unstemmed | Repeatability and Reproducibility of Retinal Fractal Dimension Measured with Swept-Source Optical Coherence Tomography Angiography in Healthy Eyes: A Proof-of-Concept Study |
| title_short | Repeatability and Reproducibility of Retinal Fractal Dimension Measured with Swept-Source Optical Coherence Tomography Angiography in Healthy Eyes: A Proof-of-Concept Study |
| title_sort | repeatability and reproducibility of retinal fractal dimension measured with swept source optical coherence tomography angiography in healthy eyes a proof of concept study |
| topic | fractal dimension healthy volunteers swept-source OCT angiography superficial retinal capillary plexus deep retinal capillary plexus retina |
| url | https://www.mdpi.com/2075-4418/12/7/1769 |
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