Dual incorporation of non-canonical amino acids enables production of post-translationally modified selenoproteins

Dual incorporation of non-canonical amino acids enables production of post-translationally modified selenoproteins

Post-translational modifications (PTMs) can occur on almost all amino acids in eukaryotes as a key mechanism for regulating protein function. The ability to study the role of these modifications in various biological processes requires techniques to modify proteins site-specifically. One strategy fo...

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Bibliographic Details
Main Authors: Pearl Morosky, Cody Comyns, Lance G. A. Nunes, Christina Z. Chung, Peter R. Hoffmann, Dieter Söll, Oscar Vargas-Rodriguez, Natalie Krahn
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Molecular Biosciences
Subjects:
selenoproteins
acetyl-lysine
post-translational modifications
genetic code expansion
selenocysteine
synthetic biology
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2023.1096261/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2023.1096261/full

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