The mode of delivery does not influence the occurrence of post-partum perianal disease flares in patients with inflammatory bowel disease
Abstract Introduction Perianal disease occurs in up to 34% of inflammatory bowel disease (IBD) patients. An estimated 25% of women will become pregnant after the initial diagnosis, thus introducing the dilemma of whether mode of delivery affects perianal disease. The aim of our study was to analyze...
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | BMC Gastroenterology |
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| Online Access: | https://doi.org/10.1186/s12876-023-03018-5 |
| _version_ | 1797349829130584064 |
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| author | Ana M. Otero-Piñerio N. Aykun M. Maspero Stefan Holubar Tracy Hull Jeremy Lipman Scott R. Steele Amy L. Lightner |
| author_facet | Ana M. Otero-Piñerio N. Aykun M. Maspero Stefan Holubar Tracy Hull Jeremy Lipman Scott R. Steele Amy L. Lightner |
| author_sort | Ana M. Otero-Piñerio |
| collection | DOAJ |
| description | Abstract Introduction Perianal disease occurs in up to 34% of inflammatory bowel disease (IBD) patients. An estimated 25% of women will become pregnant after the initial diagnosis, thus introducing the dilemma of whether mode of delivery affects perianal disease. The aim of our study was to analyze whether a cesarean section (C-section) or vaginal delivery influence perianal involvement. We hypothesized the delivery route would not alter post-partum perianal manifestations in the setting of previously healed perianal disease. Methods All consecutive eligible IBD female patients between 1997 and 2022 who delivered were included. Prior perianal involvement, perianal flare after delivery and delivery method were noted. Results We identified 190 patients with IBD who had a total of 322 deliveries; 169 (52%) were vaginal and 153 (48%) were by C-section. Nineteen women (10%) experienced 21/322 (6%) post-partum perianal flares. Independent predictors were previous abdominal surgery for IBD (OR, 2.7; 95% CI, 1–7.2; p = 0.042), ileocolonic involvement (OR, 3.3; 95% CI, 1.1–9.4; p = 0.030), previous perianal disease (OR, 22; 95% CI, 7–69; p < 0.001), active perianal disease (OR, 96; 95% CI, 21–446; p < 0.001) and biologic (OR, 4.4; 95% CI,1.4–13.6; p < 0.011) or antibiotic (OR, 19.6; 95% CI, 7–54; p < 0.001) treatment. Negative association was found for vaginal delivery (OR, 0.19; 95% CI, 0.06–0.61; p < 0.005). Number of post-partum flares was higher in the C-section group [17 (11%) vs. 4 (2%), p = 0.002]. Conclusions Delivery by C-section section was not protective of ongoing perianal disease activity post-delivery, but should be recommended for women with active perianal involvement. |
| first_indexed | 2024-03-08T12:37:05Z |
| format | Article |
| id | doaj.art-11ff434a719d4f1dafd9a83908eb4781 |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-03-08T12:37:05Z |
| publishDate | 2024-01-01 |
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| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-11ff434a719d4f1dafd9a83908eb47812024-01-21T12:23:46ZengBMCBMC Gastroenterology1471-230X2024-01-0124111010.1186/s12876-023-03018-5The mode of delivery does not influence the occurrence of post-partum perianal disease flares in patients with inflammatory bowel diseaseAna M. Otero-Piñerio0N. Aykun1M. Maspero2Stefan Holubar3Tracy Hull4Jeremy Lipman5Scott R. Steele6Amy L. Lightner7Department of Colorectal Surgery, Digestive Disease Surgical Institute, Cleveland ClinicDepartment of Colorectal Surgery, Digestive Disease Surgical Institute, Cleveland ClinicDepartment of Colorectal Surgery, Digestive Disease Surgical Institute, Cleveland ClinicDepartment of Colorectal Surgery, Digestive Disease Surgical Institute, Cleveland ClinicDepartment of Colorectal Surgery, Digestive Disease Surgical Institute, Cleveland ClinicDepartment of Colorectal Surgery, Digestive Disease Surgical Institute, Cleveland ClinicDepartment of Colorectal Surgery, Digestive Disease Surgical Institute, Cleveland ClinicDepartment of Colorectal Surgery, Digestive Disease Surgical Institute, Cleveland ClinicAbstract Introduction Perianal disease occurs in up to 34% of inflammatory bowel disease (IBD) patients. An estimated 25% of women will become pregnant after the initial diagnosis, thus introducing the dilemma of whether mode of delivery affects perianal disease. The aim of our study was to analyze whether a cesarean section (C-section) or vaginal delivery influence perianal involvement. We hypothesized the delivery route would not alter post-partum perianal manifestations in the setting of previously healed perianal disease. Methods All consecutive eligible IBD female patients between 1997 and 2022 who delivered were included. Prior perianal involvement, perianal flare after delivery and delivery method were noted. Results We identified 190 patients with IBD who had a total of 322 deliveries; 169 (52%) were vaginal and 153 (48%) were by C-section. Nineteen women (10%) experienced 21/322 (6%) post-partum perianal flares. Independent predictors were previous abdominal surgery for IBD (OR, 2.7; 95% CI, 1–7.2; p = 0.042), ileocolonic involvement (OR, 3.3; 95% CI, 1.1–9.4; p = 0.030), previous perianal disease (OR, 22; 95% CI, 7–69; p < 0.001), active perianal disease (OR, 96; 95% CI, 21–446; p < 0.001) and biologic (OR, 4.4; 95% CI,1.4–13.6; p < 0.011) or antibiotic (OR, 19.6; 95% CI, 7–54; p < 0.001) treatment. Negative association was found for vaginal delivery (OR, 0.19; 95% CI, 0.06–0.61; p < 0.005). Number of post-partum flares was higher in the C-section group [17 (11%) vs. 4 (2%), p = 0.002]. Conclusions Delivery by C-section section was not protective of ongoing perianal disease activity post-delivery, but should be recommended for women with active perianal involvement.https://doi.org/10.1186/s12876-023-03018-5Perianal DiseaseInflammatory bowel DiseaseCesarean sectionVaginal delivery |
| spellingShingle | Ana M. Otero-Piñerio N. Aykun M. Maspero Stefan Holubar Tracy Hull Jeremy Lipman Scott R. Steele Amy L. Lightner The mode of delivery does not influence the occurrence of post-partum perianal disease flares in patients with inflammatory bowel disease BMC Gastroenterology Perianal Disease Inflammatory bowel Disease Cesarean section Vaginal delivery |
| title | The mode of delivery does not influence the occurrence of post-partum perianal disease flares in patients with inflammatory bowel disease |
| title_full | The mode of delivery does not influence the occurrence of post-partum perianal disease flares in patients with inflammatory bowel disease |
| title_fullStr | The mode of delivery does not influence the occurrence of post-partum perianal disease flares in patients with inflammatory bowel disease |
| title_full_unstemmed | The mode of delivery does not influence the occurrence of post-partum perianal disease flares in patients with inflammatory bowel disease |
| title_short | The mode of delivery does not influence the occurrence of post-partum perianal disease flares in patients with inflammatory bowel disease |
| title_sort | mode of delivery does not influence the occurrence of post partum perianal disease flares in patients with inflammatory bowel disease |
| topic | Perianal Disease Inflammatory bowel Disease Cesarean section Vaginal delivery |
| url | https://doi.org/10.1186/s12876-023-03018-5 |
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