Interactions between <i>Aspergillus fumigatus</i> and Pulmonary Bacteria: Current State of the Field, New Data, and Future Perspective
<i>Aspergillus fumigatus</i> and <i>Pseudomonas aeruginosa</i> are central fungal and bacterial members of the pulmonary microbiota. The interactions between <i>A. fumigatus</i> and <i>P. aeruginosa</i> have only just begun to be explored. A balance be...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-06-01
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| Series: | Journal of Fungi |
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| Online Access: | https://www.mdpi.com/2309-608X/5/2/48 |
| _version_ | 1811296359865647104 |
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| author | Benoit Briard Gaëtan L. A. Mislin Jean-Paul Latgé Anne Beauvais |
| author_facet | Benoit Briard Gaëtan L. A. Mislin Jean-Paul Latgé Anne Beauvais |
| author_sort | Benoit Briard |
| collection | DOAJ |
| description | <i>Aspergillus fumigatus</i> and <i>Pseudomonas aeruginosa</i> are central fungal and bacterial members of the pulmonary microbiota. The interactions between <i>A. fumigatus</i> and <i>P. aeruginosa</i> have only just begun to be explored. A balance between inhibitory and stimulatory effects on fungal growth was observed in mixed <i>A. fumigatus−P. aeruginosa</i> cultures. Negative interactions have been seen for homoserine-lactones, pyoverdine and pyochelin resulting from iron starvation and intracellular inhibitory reactive oxidant production. In contrast, several types of positive interactions were recognized. Dirhamnolipids resulted in the production of a thick fungal cell wall, allowing the fungus to resist stress. Phenazines and pyochelin favor iron uptake for the fungus. <i>A. fumigatus</i> is able to use bacterial volatiles to promote its growth. The immune response is also differentially regulated by co-infections. |
| first_indexed | 2024-04-13T05:48:15Z |
| format | Article |
| id | doaj.art-1200b22b74a14814a51bc9a8e1b7c421 |
| institution | Directory Open Access Journal |
| issn | 2309-608X |
| language | English |
| last_indexed | 2024-04-13T05:48:15Z |
| publishDate | 2019-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj.art-1200b22b74a14814a51bc9a8e1b7c4212022-12-22T02:59:53ZengMDPI AGJournal of Fungi2309-608X2019-06-01524810.3390/jof5020048jof5020048Interactions between <i>Aspergillus fumigatus</i> and Pulmonary Bacteria: Current State of the Field, New Data, and Future PerspectiveBenoit Briard0Gaëtan L. A. Mislin1Jean-Paul Latgé2Anne Beauvais3Aspergillus Unit, Institut Pasteur, 75015 Paris, FranceUMR 7242 Biotechnologie et Signalisation Cellulaire, CNRS-Université de Strasbourg, 67400 Illkirch-Graffenstaden, FranceAspergillus Unit, Institut Pasteur, 75015 Paris, FranceAspergillus Unit, Institut Pasteur, 75015 Paris, France<i>Aspergillus fumigatus</i> and <i>Pseudomonas aeruginosa</i> are central fungal and bacterial members of the pulmonary microbiota. The interactions between <i>A. fumigatus</i> and <i>P. aeruginosa</i> have only just begun to be explored. A balance between inhibitory and stimulatory effects on fungal growth was observed in mixed <i>A. fumigatus−P. aeruginosa</i> cultures. Negative interactions have been seen for homoserine-lactones, pyoverdine and pyochelin resulting from iron starvation and intracellular inhibitory reactive oxidant production. In contrast, several types of positive interactions were recognized. Dirhamnolipids resulted in the production of a thick fungal cell wall, allowing the fungus to resist stress. Phenazines and pyochelin favor iron uptake for the fungus. <i>A. fumigatus</i> is able to use bacterial volatiles to promote its growth. The immune response is also differentially regulated by co-infections.https://www.mdpi.com/2309-608X/5/2/48interaction<i>Aspergillus</i>microbiotacystic fibrosis<i>Pseudomonas</i>cell wallphenazinerhamnolipidpyochelinvolatile |
| spellingShingle | Benoit Briard Gaëtan L. A. Mislin Jean-Paul Latgé Anne Beauvais Interactions between <i>Aspergillus fumigatus</i> and Pulmonary Bacteria: Current State of the Field, New Data, and Future Perspective Journal of Fungi interaction <i>Aspergillus</i> microbiota cystic fibrosis <i>Pseudomonas</i> cell wall phenazine rhamnolipid pyochelin volatile |
| title | Interactions between <i>Aspergillus fumigatus</i> and Pulmonary Bacteria: Current State of the Field, New Data, and Future Perspective |
| title_full | Interactions between <i>Aspergillus fumigatus</i> and Pulmonary Bacteria: Current State of the Field, New Data, and Future Perspective |
| title_fullStr | Interactions between <i>Aspergillus fumigatus</i> and Pulmonary Bacteria: Current State of the Field, New Data, and Future Perspective |
| title_full_unstemmed | Interactions between <i>Aspergillus fumigatus</i> and Pulmonary Bacteria: Current State of the Field, New Data, and Future Perspective |
| title_short | Interactions between <i>Aspergillus fumigatus</i> and Pulmonary Bacteria: Current State of the Field, New Data, and Future Perspective |
| title_sort | interactions between i aspergillus fumigatus i and pulmonary bacteria current state of the field new data and future perspective |
| topic | interaction <i>Aspergillus</i> microbiota cystic fibrosis <i>Pseudomonas</i> cell wall phenazine rhamnolipid pyochelin volatile |
| url | https://www.mdpi.com/2309-608X/5/2/48 |
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