Cord Blood Vitamin D, Total IgE, Cytokines Concentrations and Polyunsaturated Fatty Acids Spectrum in Newborns from Mothers with Atopic Dermatitis History
At the present time there is a hypothesis on the presence of congenital polyunsaturated fatty acids (PUA) and vitamin D metabolism disturbance, which plays its role in the pathogenesis of atopic dermatitis (AD). On the other hand, the maternal atopy may be considered as one of the important predicto...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Siberian Federal University
2010-12-01
|
| Series: | Журнал Сибирского федерального университета: Серия Биология |
| Subjects: | |
| Online Access: | http://elib.sfu-kras.ru/bitstream/2311/2252/1/Tereshchenko.pdf |
| _version_ | 1818454539533025280 |
|---|---|
| author | Sergey Yu. Tereshchenko Efim I. Prahin Ivan A. Novitzkiy Vitaly B. Tzhai Michail I. Gladyshev Nadezhda N. Sushchik Galina S. Kalachova Natalya A. Shakina Igor V. Isakov Natalya N. Gorbacheva |
| author_facet | Sergey Yu. Tereshchenko Efim I. Prahin Ivan A. Novitzkiy Vitaly B. Tzhai Michail I. Gladyshev Nadezhda N. Sushchik Galina S. Kalachova Natalya A. Shakina Igor V. Isakov Natalya N. Gorbacheva |
| author_sort | Sergey Yu. Tereshchenko |
| collection | DOAJ |
| description | At the present time there is a hypothesis on the presence of congenital polyunsaturated fatty acids (PUA) and vitamin D metabolism disturbance, which plays its role in the pathogenesis of atopic dermatitis (AD). On the other hand, the maternal atopy may be considered as one of the important predictor for allergic diseases in children. However, does this factor influence on Th1/Th2 balance forming, cord blood vitamin D and PUA concentrations already on the moment of infants birth? We used flow cytometry and ELISE techniques to study IFN , IL-1 , IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, TNF , TNF , IL-13, IL-18, IP-10, total IgE, vitamin D cord blood concentrations and mass spectrometry method to study the content of PUA in cord blood erythrocytes. These markers were studied in two newborns groups: the 1-st one is newborns from mothers without AD history (n=29) and 2-nd one is newborns from mothers with AD history (n=19). Statistical analysis was performed using the Mann-Whitney U-test. In neonates from mothers with presence AD history we found decreasing of IL-13, IL-18 cord blood concentrations and gamma-linolenic (GLA) acid percentage in cord blood erythrocytes. Thus, maternal history of AD may influence on IL-13, IL-18 and GLA production already on the moment of infant's birth which suggests genetic background and may be used as the early markers of AD predisposition. |
| first_indexed | 2024-12-14T21:56:29Z |
| format | Article |
| id | doaj.art-12029a3ee8b14dc8a571353c65a1382e |
| institution | Directory Open Access Journal |
| issn | 1997-1389 2313-5530 |
| language | English |
| last_indexed | 2024-12-14T21:56:29Z |
| publishDate | 2010-12-01 |
| publisher | Siberian Federal University |
| record_format | Article |
| series | Журнал Сибирского федерального университета: Серия Биология |
| spelling | doaj.art-12029a3ee8b14dc8a571353c65a1382e2022-12-21T22:46:07ZengSiberian Federal UniversityЖурнал Сибирского федерального университета: Серия Биология1997-13892313-55302010-12-0134407417http://elib.sfu-kras.ru/handle/2311/2252Cord Blood Vitamin D, Total IgE, Cytokines Concentrations and Polyunsaturated Fatty Acids Spectrum in Newborns from Mothers with Atopic Dermatitis HistorySergey Yu. Tereshchenko0Efim I. Prahin1Ivan A. Novitzkiy2Vitaly B. Tzhai3Michail I. Gladyshev4Nadezhda N. Sushchik5Galina S. Kalachova6Natalya A. Shakina7Igor V. Isakov8Natalya N. Gorbacheva9Medical Research Institute for Northern Problems , 3g Partizana Geleznyaka, Krasnoyarsk, 660022 RussiaMedical Research Institute for Northern Problems Krasnoyarsk State Medical University , 3g Partizana Geleznyaka, Krasnoyarsk, 660022 Russia 1 Partizana Geleznyaka, Krasnoyarsk 660022, RussiaMedical Research Institute for Northern Problems Krasnoyarsk State Medical University , 3g Partizana Geleznyaka, Krasnoyarsk, 660022 Russia 1 Partizana Geleznyaka, Krasnoyarsk 660022, RussiaKrasnoyarsk State Medical University , 1 Partizana Geleznyaka, Krasnoyarsk 660022, RussiaInstitute of Biophysics of Siberian Branch of Russian Academy of Sciences Siberian Federal University , 50 Akademgorodok, Krasnoyarsk, 660036 Russia 79 Svobodny pr., Krasnoyarsk, 660041 RussiaInstitute of Biophysics of Siberian Branch of Russian Academy of Sciences Siberian Federal University , 50 Akademgorodok, Krasnoyarsk, 660036 Russia 79 Svobodny pr., Krasnoyarsk, 660041 RussiaInstitute of Biophysics of Siberian Branch of Russian Academy of Sciences , 50 Akademgorodok, Krasnoyarsk, 660036 RussiaKrasnoyarsk Regional Centre of Prevention and Contest against HIV and other Infections , 45 Marks str., Krasnoyarsk, 660049 RussiaKrasnoyarsk Regional Centre of Prevention and Contest against HIV and other Infections , 45 Marks str., Krasnoyarsk, 660049 RussiaMedical Research Institute for Northern Problems , 3g Partizana Geleznyaka, Krasnoyarsk, 660022 RussiaAt the present time there is a hypothesis on the presence of congenital polyunsaturated fatty acids (PUA) and vitamin D metabolism disturbance, which plays its role in the pathogenesis of atopic dermatitis (AD). On the other hand, the maternal atopy may be considered as one of the important predictor for allergic diseases in children. However, does this factor influence on Th1/Th2 balance forming, cord blood vitamin D and PUA concentrations already on the moment of infants birth? We used flow cytometry and ELISE techniques to study IFN , IL-1 , IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, TNF , TNF , IL-13, IL-18, IP-10, total IgE, vitamin D cord blood concentrations and mass spectrometry method to study the content of PUA in cord blood erythrocytes. These markers were studied in two newborns groups: the 1-st one is newborns from mothers without AD history (n=29) and 2-nd one is newborns from mothers with AD history (n=19). Statistical analysis was performed using the Mann-Whitney U-test. In neonates from mothers with presence AD history we found decreasing of IL-13, IL-18 cord blood concentrations and gamma-linolenic (GLA) acid percentage in cord blood erythrocytes. Thus, maternal history of AD may influence on IL-13, IL-18 and GLA production already on the moment of infant's birth which suggests genetic background and may be used as the early markers of AD predisposition.http://elib.sfu-kras.ru/bitstream/2311/2252/1/Tereshchenko.pdfnewborncord bloodcytokinesvitamin Dfatty acidserythrocyte membranesatopic dermatitis |
| spellingShingle | Sergey Yu. Tereshchenko Efim I. Prahin Ivan A. Novitzkiy Vitaly B. Tzhai Michail I. Gladyshev Nadezhda N. Sushchik Galina S. Kalachova Natalya A. Shakina Igor V. Isakov Natalya N. Gorbacheva Cord Blood Vitamin D, Total IgE, Cytokines Concentrations and Polyunsaturated Fatty Acids Spectrum in Newborns from Mothers with Atopic Dermatitis History Журнал Сибирского федерального университета: Серия Биология newborn cord blood cytokines vitamin D fatty acids erythrocyte membranes atopic dermatitis |
| title | Cord Blood Vitamin D, Total IgE, Cytokines Concentrations and Polyunsaturated Fatty Acids Spectrum in Newborns from Mothers with Atopic Dermatitis History |
| title_full | Cord Blood Vitamin D, Total IgE, Cytokines Concentrations and Polyunsaturated Fatty Acids Spectrum in Newborns from Mothers with Atopic Dermatitis History |
| title_fullStr | Cord Blood Vitamin D, Total IgE, Cytokines Concentrations and Polyunsaturated Fatty Acids Spectrum in Newborns from Mothers with Atopic Dermatitis History |
| title_full_unstemmed | Cord Blood Vitamin D, Total IgE, Cytokines Concentrations and Polyunsaturated Fatty Acids Spectrum in Newborns from Mothers with Atopic Dermatitis History |
| title_short | Cord Blood Vitamin D, Total IgE, Cytokines Concentrations and Polyunsaturated Fatty Acids Spectrum in Newborns from Mothers with Atopic Dermatitis History |
| title_sort | cord blood vitamin d total ige cytokines concentrations and polyunsaturated fatty acids spectrum in newborns from mothers with atopic dermatitis history |
| topic | newborn cord blood cytokines vitamin D fatty acids erythrocyte membranes atopic dermatitis |
| url | http://elib.sfu-kras.ru/bitstream/2311/2252/1/Tereshchenko.pdf |
| work_keys_str_mv | AT sergeyyutereshchenko cordbloodvitamindtotaligecytokinesconcentrationsandpolyunsaturatedfattyacidsspectruminnewbornsfrommotherswithatopicdermatitishistory AT efimiprahin cordbloodvitamindtotaligecytokinesconcentrationsandpolyunsaturatedfattyacidsspectruminnewbornsfrommotherswithatopicdermatitishistory AT ivananovitzkiy cordbloodvitamindtotaligecytokinesconcentrationsandpolyunsaturatedfattyacidsspectruminnewbornsfrommotherswithatopicdermatitishistory AT vitalybtzhai cordbloodvitamindtotaligecytokinesconcentrationsandpolyunsaturatedfattyacidsspectruminnewbornsfrommotherswithatopicdermatitishistory AT michailigladyshev cordbloodvitamindtotaligecytokinesconcentrationsandpolyunsaturatedfattyacidsspectruminnewbornsfrommotherswithatopicdermatitishistory AT nadezhdansushchik cordbloodvitamindtotaligecytokinesconcentrationsandpolyunsaturatedfattyacidsspectruminnewbornsfrommotherswithatopicdermatitishistory AT galinaskalachova cordbloodvitamindtotaligecytokinesconcentrationsandpolyunsaturatedfattyacidsspectruminnewbornsfrommotherswithatopicdermatitishistory AT natalyaashakina cordbloodvitamindtotaligecytokinesconcentrationsandpolyunsaturatedfattyacidsspectruminnewbornsfrommotherswithatopicdermatitishistory AT igorvisakov cordbloodvitamindtotaligecytokinesconcentrationsandpolyunsaturatedfattyacidsspectruminnewbornsfrommotherswithatopicdermatitishistory AT natalyangorbacheva cordbloodvitamindtotaligecytokinesconcentrationsandpolyunsaturatedfattyacidsspectruminnewbornsfrommotherswithatopicdermatitishistory |