Pseudomonas aeruginosa in Chronic Lung Infections: How to Adapt Within the Host?
Bacteria that readily adapt to different natural environments, can also exploit this versatility upon infection of the host to persist. Pseudomonas aeruginosa, a ubiquitous Gram-negative bacterium, is harmless to healthy individuals, and yet a formidable opportunistic pathogen in compromised hosts....
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-10-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2018.02416/full |
| _version_ | 1818153950866571264 |
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| author | Emmanuel Faure Emmanuel Faure Kelly Kwong Kelly Kwong Dao Nguyen Dao Nguyen |
| author_facet | Emmanuel Faure Emmanuel Faure Kelly Kwong Kelly Kwong Dao Nguyen Dao Nguyen |
| author_sort | Emmanuel Faure |
| collection | DOAJ |
| description | Bacteria that readily adapt to different natural environments, can also exploit this versatility upon infection of the host to persist. Pseudomonas aeruginosa, a ubiquitous Gram-negative bacterium, is harmless to healthy individuals, and yet a formidable opportunistic pathogen in compromised hosts. When pathogenic, P. aeruginosa causes invasive and highly lethal disease in certain compromised hosts. In others, such as individuals with the genetic disease cystic fibrosis, this pathogen causes chronic lung infections which persist for decades. During chronic lung infections, P. aeruginosa adapts to the host environment by evolving toward a state of reduced bacterial invasiveness that favors bacterial persistence without causing overwhelming host injury. Host responses to chronic P. aeruginosa infections are complex and dynamic, ranging from vigorous activation of innate immune responses that are ineffective at eradicating the infecting bacteria, to relative host tolerance and dampened activation of host immunity. This review will examine how P. aeruginosa subverts host defenses and modulates immune and inflammatory responses during chronic infection. This dynamic interplay between host and pathogen is a major determinant in the pathogenesis of chronic P. aeruginosa lung infections. |
| first_indexed | 2024-12-11T14:18:46Z |
| format | Article |
| id | doaj.art-12032673905940f384dee42c874d08d6 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T14:18:46Z |
| publishDate | 2018-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-12032673905940f384dee42c874d08d62022-12-22T01:03:00ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-10-01910.3389/fimmu.2018.02416404088Pseudomonas aeruginosa in Chronic Lung Infections: How to Adapt Within the Host?Emmanuel Faure0Emmanuel Faure1Kelly Kwong2Kelly Kwong3Dao Nguyen4Dao Nguyen5Department of Medicine, McGill University, Montreal, QC, CanadaResearch Institute of the McGill University Health Center, Montreal, QC, CanadaDepartment of Medicine, McGill University, Montreal, QC, CanadaResearch Institute of the McGill University Health Center, Montreal, QC, CanadaDepartment of Medicine, McGill University, Montreal, QC, CanadaResearch Institute of the McGill University Health Center, Montreal, QC, CanadaBacteria that readily adapt to different natural environments, can also exploit this versatility upon infection of the host to persist. Pseudomonas aeruginosa, a ubiquitous Gram-negative bacterium, is harmless to healthy individuals, and yet a formidable opportunistic pathogen in compromised hosts. When pathogenic, P. aeruginosa causes invasive and highly lethal disease in certain compromised hosts. In others, such as individuals with the genetic disease cystic fibrosis, this pathogen causes chronic lung infections which persist for decades. During chronic lung infections, P. aeruginosa adapts to the host environment by evolving toward a state of reduced bacterial invasiveness that favors bacterial persistence without causing overwhelming host injury. Host responses to chronic P. aeruginosa infections are complex and dynamic, ranging from vigorous activation of innate immune responses that are ineffective at eradicating the infecting bacteria, to relative host tolerance and dampened activation of host immunity. This review will examine how P. aeruginosa subverts host defenses and modulates immune and inflammatory responses during chronic infection. This dynamic interplay between host and pathogen is a major determinant in the pathogenesis of chronic P. aeruginosa lung infections.https://www.frontiersin.org/article/10.3389/fimmu.2018.02416/fullPseudomonas aeruginosacystic fibrosisimmune evasionchronic lung infectionhost evasionbacterial adaptation |
| spellingShingle | Emmanuel Faure Emmanuel Faure Kelly Kwong Kelly Kwong Dao Nguyen Dao Nguyen Pseudomonas aeruginosa in Chronic Lung Infections: How to Adapt Within the Host? Frontiers in Immunology Pseudomonas aeruginosa cystic fibrosis immune evasion chronic lung infection host evasion bacterial adaptation |
| title | Pseudomonas aeruginosa in Chronic Lung Infections: How to Adapt Within the Host? |
| title_full | Pseudomonas aeruginosa in Chronic Lung Infections: How to Adapt Within the Host? |
| title_fullStr | Pseudomonas aeruginosa in Chronic Lung Infections: How to Adapt Within the Host? |
| title_full_unstemmed | Pseudomonas aeruginosa in Chronic Lung Infections: How to Adapt Within the Host? |
| title_short | Pseudomonas aeruginosa in Chronic Lung Infections: How to Adapt Within the Host? |
| title_sort | pseudomonas aeruginosa in chronic lung infections how to adapt within the host |
| topic | Pseudomonas aeruginosa cystic fibrosis immune evasion chronic lung infection host evasion bacterial adaptation |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2018.02416/full |
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