Mechanisms of manganese-induced neurotoxicity and the pursuit of neurotherapeutic strategies

Mechanisms of manganese-induced neurotoxicity and the pursuit of neurotherapeutic strategies

Chronic exposure to elevated levels of manganese via occupational or environmental settings causes a neurological disorder known as manganism, resembling the symptoms of Parkinson’s disease, such as motor deficits and cognitive impairment. Numerous studies have been conducted to characterize mangane...

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Bibliographic Details
Main Authors: Edward Pajarillo, Ivan Nyarko-Danquah, Alexis Digman, Harpreet Kaur Multani, Sanghoon Kim, Patric Gaspard, Michael Aschner, Eunsook Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Pharmacology
Subjects:
manganese
oxidative stress
inflammation
autophagy
mitophagy
excitotoxicity
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.1011947/full

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