Controversies and Opportunities in the Clinical Daily Use of the 21-Gene Assay for Prognostication and Prediction of Chemotherapy Benefit in HR+/HER2- Early Breast Cancer
Several multigene assays have been developed to help clinicians in defining adjuvant treatment for patients with hormone-receptor-positive (HR+), human epidermal growth factor receptor-2 (HER2)–negative early breast cancer. Despite the 21-gene assay having been available for decades, it has only rec...
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MDPI AG
2022-12-01
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Online Access: | https://www.mdpi.com/2072-6694/15/1/148 |
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author | Flavia Jacobs Mariangela Gaudio Chiara Benvenuti Rita De Sanctis Armando Santoro Alberto Zambelli |
author_facet | Flavia Jacobs Mariangela Gaudio Chiara Benvenuti Rita De Sanctis Armando Santoro Alberto Zambelli |
author_sort | Flavia Jacobs |
collection | DOAJ |
description | Several multigene assays have been developed to help clinicians in defining adjuvant treatment for patients with hormone-receptor-positive (HR+), human epidermal growth factor receptor-2 (HER2)–negative early breast cancer. Despite the 21-gene assay having been available for decades, it has only recently been included in the healthcare systems of several countries. Clinical optimisation of the test remains of critical interest to achieve a greater impact of genomic information in HR+/HER2- early breast cancer. Although current guidelines recommend the use of the 21-gene assay in early breast cancer at intermediate risk of relapse, the implication of the Recurrence Score (RS) in some grey areas still remains uncertain. Our aim is to critically discuss the role of RS in peculiar circumstances. In particular, we focus on the complex integration of genomic data with clinicopathological factors; the potential clinical impact of RS in node-positive premenopausal women and in the neoadjuvant setting; the significance of RS in special histologies and in male patients; and the management and time-optimisation of test ordering. In the absence of robust evidence in these areas, we provide perspectives for improving the use of the 21-gene assay in the decision-making process and guide adjuvant treatment decisions even in challenging cases. |
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issn | 2072-6694 |
language | English |
last_indexed | 2024-03-11T10:06:34Z |
publishDate | 2022-12-01 |
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spelling | doaj.art-1207f6f605614bfb9d47402fe326959b2023-11-16T15:02:17ZengMDPI AGCancers2072-66942022-12-0115114810.3390/cancers15010148Controversies and Opportunities in the Clinical Daily Use of the 21-Gene Assay for Prognostication and Prediction of Chemotherapy Benefit in HR+/HER2- Early Breast CancerFlavia Jacobs0Mariangela Gaudio1Chiara Benvenuti2Rita De Sanctis3Armando Santoro4Alberto Zambelli5IRCCS Humanitas Research Hospital, Humanitas Cancer Center, Via Manzoni 56, 20089 Rozzano, MI, ItalyIRCCS Humanitas Research Hospital, Humanitas Cancer Center, Via Manzoni 56, 20089 Rozzano, MI, ItalyIRCCS Humanitas Research Hospital, Humanitas Cancer Center, Via Manzoni 56, 20089 Rozzano, MI, ItalyIRCCS Humanitas Research Hospital, Humanitas Cancer Center, Via Manzoni 56, 20089 Rozzano, MI, ItalyIRCCS Humanitas Research Hospital, Humanitas Cancer Center, Via Manzoni 56, 20089 Rozzano, MI, ItalyIRCCS Humanitas Research Hospital, Humanitas Cancer Center, Via Manzoni 56, 20089 Rozzano, MI, ItalySeveral multigene assays have been developed to help clinicians in defining adjuvant treatment for patients with hormone-receptor-positive (HR+), human epidermal growth factor receptor-2 (HER2)–negative early breast cancer. Despite the 21-gene assay having been available for decades, it has only recently been included in the healthcare systems of several countries. Clinical optimisation of the test remains of critical interest to achieve a greater impact of genomic information in HR+/HER2- early breast cancer. Although current guidelines recommend the use of the 21-gene assay in early breast cancer at intermediate risk of relapse, the implication of the Recurrence Score (RS) in some grey areas still remains uncertain. Our aim is to critically discuss the role of RS in peculiar circumstances. In particular, we focus on the complex integration of genomic data with clinicopathological factors; the potential clinical impact of RS in node-positive premenopausal women and in the neoadjuvant setting; the significance of RS in special histologies and in male patients; and the management and time-optimisation of test ordering. In the absence of robust evidence in these areas, we provide perspectives for improving the use of the 21-gene assay in the decision-making process and guide adjuvant treatment decisions even in challenging cases.https://www.mdpi.com/2072-6694/15/1/148genomic signatureOncotypeDXprecision medicineHR-positive early breast canceradjuvant chemotherapyclinicopathological factors |
spellingShingle | Flavia Jacobs Mariangela Gaudio Chiara Benvenuti Rita De Sanctis Armando Santoro Alberto Zambelli Controversies and Opportunities in the Clinical Daily Use of the 21-Gene Assay for Prognostication and Prediction of Chemotherapy Benefit in HR+/HER2- Early Breast Cancer Cancers genomic signature OncotypeDX precision medicine HR-positive early breast cancer adjuvant chemotherapy clinicopathological factors |
title | Controversies and Opportunities in the Clinical Daily Use of the 21-Gene Assay for Prognostication and Prediction of Chemotherapy Benefit in HR+/HER2- Early Breast Cancer |
title_full | Controversies and Opportunities in the Clinical Daily Use of the 21-Gene Assay for Prognostication and Prediction of Chemotherapy Benefit in HR+/HER2- Early Breast Cancer |
title_fullStr | Controversies and Opportunities in the Clinical Daily Use of the 21-Gene Assay for Prognostication and Prediction of Chemotherapy Benefit in HR+/HER2- Early Breast Cancer |
title_full_unstemmed | Controversies and Opportunities in the Clinical Daily Use of the 21-Gene Assay for Prognostication and Prediction of Chemotherapy Benefit in HR+/HER2- Early Breast Cancer |
title_short | Controversies and Opportunities in the Clinical Daily Use of the 21-Gene Assay for Prognostication and Prediction of Chemotherapy Benefit in HR+/HER2- Early Breast Cancer |
title_sort | controversies and opportunities in the clinical daily use of the 21 gene assay for prognostication and prediction of chemotherapy benefit in hr her2 early breast cancer |
topic | genomic signature OncotypeDX precision medicine HR-positive early breast cancer adjuvant chemotherapy clinicopathological factors |
url | https://www.mdpi.com/2072-6694/15/1/148 |
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