Hidden long-range memories of growth and cycle speed correlate cell cycles in lineage trees
Cell heterogeneity may be caused by stochastic or deterministic effects. The inheritance of regulators through cell division is a key deterministic force, but identifying inheritance effects in a systematic manner has been challenging. Here, we measure and analyze cell cycles in deep lineage trees o...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2020-01-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/51002 |
| _version_ | 1811199733670084608 |
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| author | Erika E Kuchen Nils B Becker Nina Claudino Thomas Höfer |
| author_facet | Erika E Kuchen Nils B Becker Nina Claudino Thomas Höfer |
| author_sort | Erika E Kuchen |
| collection | DOAJ |
| description | Cell heterogeneity may be caused by stochastic or deterministic effects. The inheritance of regulators through cell division is a key deterministic force, but identifying inheritance effects in a systematic manner has been challenging. Here, we measure and analyze cell cycles in deep lineage trees of human cancer cells and mouse embryonic stem cells and develop a statistical framework to infer underlying rules of inheritance. The observed long-range intra-generational correlations in cell-cycle duration, up to second cousins, seem paradoxical because ancestral correlations decay rapidly. However, this correlation pattern is naturally explained by the inheritance of both cell size and cell-cycle speed over several generations, provided that cell growth and division are coupled through a minimum-size checkpoint. This model correctly predicts the effects of inhibiting cell growth or cycle progression. In sum, we show how fluctuations of cell cycles across lineage trees help in understanding the coordination of cell growth and division. |
| first_indexed | 2024-04-12T01:52:18Z |
| format | Article |
| id | doaj.art-1209053ba7064e51b1cefe170e40feea |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T01:52:18Z |
| publishDate | 2020-01-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-1209053ba7064e51b1cefe170e40feea2022-12-22T03:52:53ZengeLife Sciences Publications LtdeLife2050-084X2020-01-01910.7554/eLife.51002Hidden long-range memories of growth and cycle speed correlate cell cycles in lineage treesErika E Kuchen0Nils B Becker1https://orcid.org/0000-0002-7490-6425Nina Claudino2Thomas Höfer3https://orcid.org/0000-0003-3560-8780Theoretical Systems Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Bioquant Center, University of Heidelberg, Heidelberg, GermanyTheoretical Systems Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Bioquant Center, University of Heidelberg, Heidelberg, GermanyTheoretical Systems Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Bioquant Center, University of Heidelberg, Heidelberg, GermanyTheoretical Systems Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Bioquant Center, University of Heidelberg, Heidelberg, GermanyCell heterogeneity may be caused by stochastic or deterministic effects. The inheritance of regulators through cell division is a key deterministic force, but identifying inheritance effects in a systematic manner has been challenging. Here, we measure and analyze cell cycles in deep lineage trees of human cancer cells and mouse embryonic stem cells and develop a statistical framework to infer underlying rules of inheritance. The observed long-range intra-generational correlations in cell-cycle duration, up to second cousins, seem paradoxical because ancestral correlations decay rapidly. However, this correlation pattern is naturally explained by the inheritance of both cell size and cell-cycle speed over several generations, provided that cell growth and division are coupled through a minimum-size checkpoint. This model correctly predicts the effects of inhibiting cell growth or cycle progression. In sum, we show how fluctuations of cell cycles across lineage trees help in understanding the coordination of cell growth and division.https://elifesciences.org/articles/51002cell lineagescell cyclecell growthHidden-Markov modelsize checkpointcellular memory |
| spellingShingle | Erika E Kuchen Nils B Becker Nina Claudino Thomas Höfer Hidden long-range memories of growth and cycle speed correlate cell cycles in lineage trees eLife cell lineages cell cycle cell growth Hidden-Markov model size checkpoint cellular memory |
| title | Hidden long-range memories of growth and cycle speed correlate cell cycles in lineage trees |
| title_full | Hidden long-range memories of growth and cycle speed correlate cell cycles in lineage trees |
| title_fullStr | Hidden long-range memories of growth and cycle speed correlate cell cycles in lineage trees |
| title_full_unstemmed | Hidden long-range memories of growth and cycle speed correlate cell cycles in lineage trees |
| title_short | Hidden long-range memories of growth and cycle speed correlate cell cycles in lineage trees |
| title_sort | hidden long range memories of growth and cycle speed correlate cell cycles in lineage trees |
| topic | cell lineages cell cycle cell growth Hidden-Markov model size checkpoint cellular memory |
| url | https://elifesciences.org/articles/51002 |
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