Zebrafish knockout of Down syndrome gene, DYRK1A, shows social impairments relevant to autism

Zebrafish knockout of Down syndrome gene, DYRK1A, shows social impairments relevant to autism

Abstract Background DYRK1A maps to the Down syndrome critical region at 21q22. Mutations in this kinase-encoding gene have been reported to cause microcephaly associated with either intellectual disability or autism in humans. Intellectual disability accompanied by microcephaly was recapitulated in...

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Bibliographic Details
Main Authors: Oc-Hee Kim, Hyun-Ju Cho, Enna Han, Ted Inpyo Hong, Krishan Ariyasiri, Jung-Hwa Choi, Kyu-Seok Hwang, Yun-Mi Jeong, Se-Yeol Yang, Kweon Yu, Doo-Sang Park, Hyun-Woo Oh, Erica E. Davis, Charles E. Schwartz, Jeong-Soo Lee, Hyung-Goo Kim, Cheol-Hee Kim
Format: Article
Language:English
Published: BMC 2017-09-01
Series:Molecular Autism
Subjects:
Autism
Down syndrome
Knockout
Zebrafish
DYRK1A
Social interaction
Online Access:http://link.springer.com/article/10.1186/s13229-017-0168-2

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