The impact of mouse passaging of Mycobacterium tuberculosis strains prior to virulence testing in the mouse and guinea pig aerosol models.

The impact of mouse passaging of Mycobacterium tuberculosis strains prior to virulence testing in the mouse and guinea pig aerosol models.

It has been hypothesized that the virulence of lab-passaged Mycobacterium tuberculosis and recombinant M. tuberculosis mutants might be reduced due to multiple in vitro passages, and that virulence might be augmented by passage of these strains through mice before quantitative virulence testing in t...

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Bibliographic Details
Main Authors: Paul J Converse, Kathleen D Eisenach, Sue A Theus, Eric L Nuermberger, Sandeep Tyagi, Lan H Ly, Deborah E Geiman, Haidan Guo, Scott T Nolan, Nicole C Akar, Lee G Klinkenberg, Radhika Gupta, Shichun Lun, Petros C Karakousis, Gyanu Lamichhane, David N McMurray, Jacques H Grosset, William R Bishai
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-04-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2858211?pdf=render

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