Mitochondrial respiratory chain deficiency correlates with the severity of neuropathology in sporadic Creutzfeldt-Jakob disease

Mitochondrial respiratory chain deficiency correlates with the severity of neuropathology in sporadic Creutzfeldt-Jakob disease

Abstract Mitochondrial dysfunction has been implicated in multiple neurodegenerative diseases but remains largely unexplored in Creutzfeldt-Jakob disease. Here, we characterize the mitochondrial respiratory chain at the individual neuron level in the MM1 and VV2 common molecular subtypes of sporadic...

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Bibliographic Details
Main Authors: Irene H. Flønes, Gerda Ricken, Sigrid Klotz, Alexandra Lang, Thomas Ströbel, Christian Dölle, Gabor G. Kovacs, Charalampos Tzoulis
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Acta Neuropathologica Communications
Subjects:
Mitochondria
Respiratory chain
Prion
Neurodegeneration
PrP
Online Access:http://link.springer.com/article/10.1186/s40478-020-00915-8

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