Ionic signalling and mitochondrial dynamics

Ionic signalling and mitochondrial dynamics

In age-related diseases, rise in intracellular reactive oxygen species (ROS) causes fragmentation of mitochondrial network. Our recent study demonstrated that ROS activation of TRPM2 (transient receptor potential melastatin-2) channels triggers lysosomal Zn2+ release that, in turn, triggers mitochon...

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Bibliographic Details
Main Authors: Nada Abuarab, Fangfang Li, Asipu Sivaprasadarao
Format: Article
Language:English
Published: Taylor & Francis Group 2017-11-01
Series:Molecular & Cellular Oncology
Subjects:
calcium
cell proliferation
cell migration
lysosomal membrane permeabilisation
mitochondrial dynamics
oxidative stress
reactive oxygen species
trpm2
zinc
Online Access:http://dx.doi.org/10.1080/23723556.2017.1373889

Internet

http://dx.doi.org/10.1080/23723556.2017.1373889

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