GENETIC MARKERS OF NEGATIVE OUTCOMES OF THE ACUTE CORONARY SYNDROME
Aim. To evaluate the relationship of 8 mononucleotide polymorphisms (MNP) with negative longterm prognosis of the acute coronary syndrome.Material and methods. Totally 280 patients with acute coronary syndrome included (ACS), who during 1 year follow up were underwent the solid endpoints evaluation...
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| Format: | Article |
| Language: | Russian |
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«FIRMA «SILICEA» LLC
2014-10-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/29 |
| _version_ | 1826561408548995072 |
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| author | N. G. Lozhkina V. N. Maksimov P. S. Orlov Kuimov A. D. M. I. Voevoda |
| author_facet | N. G. Lozhkina V. N. Maksimov P. S. Orlov Kuimov A. D. M. I. Voevoda |
| author_sort | N. G. Lozhkina |
| collection | DOAJ |
| description | Aim. To evaluate the relationship of 8 mononucleotide polymorphisms (MNP) with negative longterm prognosis of the acute coronary syndrome.Material and methods. Totally 280 patients with acute coronary syndrome included (ACS), who during 1 year follow up were underwent the solid endpoints evaluation (cardiovascular death, hospitalization for recurrent ischemic event and repeated revascularization).Results. In the analysis of rs4804611 in group with negative outcomes there is significantly more prevalent genotype GG (9,1% vs. 1,8%), chances relation 5,57 (95% CI 1,35-22,96); credibility of the differences kept in men (p=0,021). In the analysis rs2549513 in the group with positive prognosis the AA genotype was more prevalent (70,6% vs. 53%), hazard ratio 0,47 (95% CI 0,26-0,85), and in the group with negative prognosis genotype AC, chances relation 2,32 (95% CI 1,28-4,20; р=0,007).While separated by gender credible differences were shown only in men (p=0,008).Conclusion. Evaluation of genetic markers rs4804611 and rs2549513 can significantly increase prognostic value in riskometry of ACS outcomes. |
| first_indexed | 2024-04-09T20:49:32Z |
| format | Article |
| id | doaj.art-120fd2fabb194fe885d1b06806ebf264 |
| institution | Directory Open Access Journal |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| last_indexed | 2025-03-14T09:31:42Z |
| publishDate | 2014-10-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj.art-120fd2fabb194fe885d1b06806ebf2642025-03-02T11:42:34Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202014-10-01010192210.15829/1560-4071-2014-10-19-2229GENETIC MARKERS OF NEGATIVE OUTCOMES OF THE ACUTE CORONARY SYNDROMEN. G. Lozhkina0V. N. Maksimov1P. S. Orlov2Kuimov A. D.3M. I. Voevoda4Novosibirsk State Medical University of the MH RFNovosibirsk State Medical University of the MH RF; Scientific-Research Institute for Therapy and Prevention of the SD RAMS, NovosibirskScientific-Research Institute for Therapy and Prevention of the SD RAMS; Institute for Cytology and Genetics of SD RAMS, NovosibirskNovosibirsk State Medical University of the MH RFScientific-Research Institute for Therapy and Prevention of the SD RAMS; Institute for Cytology and Genetics of SD RAMS, NovosibirskAim. To evaluate the relationship of 8 mononucleotide polymorphisms (MNP) with negative longterm prognosis of the acute coronary syndrome.Material and methods. Totally 280 patients with acute coronary syndrome included (ACS), who during 1 year follow up were underwent the solid endpoints evaluation (cardiovascular death, hospitalization for recurrent ischemic event and repeated revascularization).Results. In the analysis of rs4804611 in group with negative outcomes there is significantly more prevalent genotype GG (9,1% vs. 1,8%), chances relation 5,57 (95% CI 1,35-22,96); credibility of the differences kept in men (p=0,021). In the analysis rs2549513 in the group with positive prognosis the AA genotype was more prevalent (70,6% vs. 53%), hazard ratio 0,47 (95% CI 0,26-0,85), and in the group with negative prognosis genotype AC, chances relation 2,32 (95% CI 1,28-4,20; р=0,007).While separated by gender credible differences were shown only in men (p=0,008).Conclusion. Evaluation of genetic markers rs4804611 and rs2549513 can significantly increase prognostic value in riskometry of ACS outcomes.https://russjcardiol.elpub.ru/jour/article/view/29prognosisacute coronary syndromegenetic markers |
| spellingShingle | N. G. Lozhkina V. N. Maksimov P. S. Orlov Kuimov A. D. M. I. Voevoda GENETIC MARKERS OF NEGATIVE OUTCOMES OF THE ACUTE CORONARY SYNDROME Российский кардиологический журнал prognosis acute coronary syndrome genetic markers |
| title | GENETIC MARKERS OF NEGATIVE OUTCOMES OF THE ACUTE CORONARY SYNDROME |
| title_full | GENETIC MARKERS OF NEGATIVE OUTCOMES OF THE ACUTE CORONARY SYNDROME |
| title_fullStr | GENETIC MARKERS OF NEGATIVE OUTCOMES OF THE ACUTE CORONARY SYNDROME |
| title_full_unstemmed | GENETIC MARKERS OF NEGATIVE OUTCOMES OF THE ACUTE CORONARY SYNDROME |
| title_short | GENETIC MARKERS OF NEGATIVE OUTCOMES OF THE ACUTE CORONARY SYNDROME |
| title_sort | genetic markers of negative outcomes of the acute coronary syndrome |
| topic | prognosis acute coronary syndrome genetic markers |
| url | https://russjcardiol.elpub.ru/jour/article/view/29 |
| work_keys_str_mv | AT nglozhkina geneticmarkersofnegativeoutcomesoftheacutecoronarysyndrome AT vnmaksimov geneticmarkersofnegativeoutcomesoftheacutecoronarysyndrome AT psorlov geneticmarkersofnegativeoutcomesoftheacutecoronarysyndrome AT kuimovad geneticmarkersofnegativeoutcomesoftheacutecoronarysyndrome AT mivoevoda geneticmarkersofnegativeoutcomesoftheacutecoronarysyndrome |