TLR/WNT: A Novel Relationship in Immunomodulation of Lung Cancer
The most frequent cause of death by cancer worldwide is lung cancer, and the 5-year survival rate is still very poor for patients with advanced stage. Understanding the crosstalk between the signaling pathways that are involved in disease, especially in metastasis, is crucial to developing new targe...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/12/6539 |
| _version_ | 1797486542551252992 |
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| author | Aina Martín-Medina Noemi Cerón-Pisa Esther Martinez-Font Hanaa Shafiek Antònia Obrador-Hevia Jaume Sauleda Amanda Iglesias |
| author_facet | Aina Martín-Medina Noemi Cerón-Pisa Esther Martinez-Font Hanaa Shafiek Antònia Obrador-Hevia Jaume Sauleda Amanda Iglesias |
| author_sort | Aina Martín-Medina |
| collection | DOAJ |
| description | The most frequent cause of death by cancer worldwide is lung cancer, and the 5-year survival rate is still very poor for patients with advanced stage. Understanding the crosstalk between the signaling pathways that are involved in disease, especially in metastasis, is crucial to developing new targeted therapies. Toll-like receptors (TLRs) are master regulators of the immune responses, and their dysregulation in lung cancer is linked to immune escape and promotes tumor malignancy by facilitating angiogenesis and proliferation. On the other hand, over-activation of the WNT signaling pathway has been reported in lung cancer and is also associated with tumor metastasis via induction of Epithelial-to-mesenchymal-transition (EMT)-like processes. An interaction between both TLRs and the WNT pathway was discovered recently as it was found that the TLR pathway can be activated by WNT ligands in the tumor microenvironment; however, the implications of such interactions in the context of lung cancer have not been discussed yet. Here, we offer an overview of the interaction of TLR-WNT in the lung and its potential implications and role in the oncogenic process. |
| first_indexed | 2024-03-09T23:34:45Z |
| format | Article |
| id | doaj.art-12109fbcda844a2ea9125a41b0ba3870 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T23:34:45Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-12109fbcda844a2ea9125a41b0ba38702023-11-23T17:02:30ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-06-012312653910.3390/ijms23126539TLR/WNT: A Novel Relationship in Immunomodulation of Lung CancerAina Martín-Medina0Noemi Cerón-Pisa1Esther Martinez-Font2Hanaa Shafiek3Antònia Obrador-Hevia4Jaume Sauleda5Amanda Iglesias6Instituto de Investigación Sanitaria de les Illes Balears (IdISBa), 07120 Palma, SpainInstituto de Investigación Sanitaria de les Illes Balears (IdISBa), 07120 Palma, SpainInstituto de Investigación Sanitaria de les Illes Balears (IdISBa), 07120 Palma, SpainChest Diseases Department, Faculty of Medicine, Alexandria University, Alexandria 21526, EgyptInstituto de Investigación Sanitaria de les Illes Balears (IdISBa), 07120 Palma, SpainInstituto de Investigación Sanitaria de les Illes Balears (IdISBa), 07120 Palma, SpainInstituto de Investigación Sanitaria de les Illes Balears (IdISBa), 07120 Palma, SpainThe most frequent cause of death by cancer worldwide is lung cancer, and the 5-year survival rate is still very poor for patients with advanced stage. Understanding the crosstalk between the signaling pathways that are involved in disease, especially in metastasis, is crucial to developing new targeted therapies. Toll-like receptors (TLRs) are master regulators of the immune responses, and their dysregulation in lung cancer is linked to immune escape and promotes tumor malignancy by facilitating angiogenesis and proliferation. On the other hand, over-activation of the WNT signaling pathway has been reported in lung cancer and is also associated with tumor metastasis via induction of Epithelial-to-mesenchymal-transition (EMT)-like processes. An interaction between both TLRs and the WNT pathway was discovered recently as it was found that the TLR pathway can be activated by WNT ligands in the tumor microenvironment; however, the implications of such interactions in the context of lung cancer have not been discussed yet. Here, we offer an overview of the interaction of TLR-WNT in the lung and its potential implications and role in the oncogenic process.https://www.mdpi.com/1422-0067/23/12/6539TLRWNTlung cancer |
| spellingShingle | Aina Martín-Medina Noemi Cerón-Pisa Esther Martinez-Font Hanaa Shafiek Antònia Obrador-Hevia Jaume Sauleda Amanda Iglesias TLR/WNT: A Novel Relationship in Immunomodulation of Lung Cancer International Journal of Molecular Sciences TLR WNT lung cancer |
| title | TLR/WNT: A Novel Relationship in Immunomodulation of Lung Cancer |
| title_full | TLR/WNT: A Novel Relationship in Immunomodulation of Lung Cancer |
| title_fullStr | TLR/WNT: A Novel Relationship in Immunomodulation of Lung Cancer |
| title_full_unstemmed | TLR/WNT: A Novel Relationship in Immunomodulation of Lung Cancer |
| title_short | TLR/WNT: A Novel Relationship in Immunomodulation of Lung Cancer |
| title_sort | tlr wnt a novel relationship in immunomodulation of lung cancer |
| topic | TLR WNT lung cancer |
| url | https://www.mdpi.com/1422-0067/23/12/6539 |
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