Porphyria cutanea tarda: An uncommon condition in a patient on chronic hemodialysis
Patients with chronic kidney disease can have many dermatological manifestations. One of the very rare conditions is porphyria cutanea tarda (PCT), which manifests with hyperpigmentation of skin and photosensitivity along with painful bullae in sun-exposed areas. It is due to deficiency of uroporphy...
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Format: | Article |
Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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Series: | APIK Journal of Internal Medicine |
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Online Access: | http://www.ajim.in/article.asp?issn=2666-1802;year=2023;volume=11;issue=1;spage=53;epage=55;aulast=Anupama |
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author | Yedabettu Janardhana Anupama Yabagodu Ramavakoda Parameshwara |
author_facet | Yedabettu Janardhana Anupama Yabagodu Ramavakoda Parameshwara |
author_sort | Yedabettu Janardhana Anupama |
collection | DOAJ |
description | Patients with chronic kidney disease can have many dermatological manifestations. One of the very rare conditions is porphyria cutanea tarda (PCT), which manifests with hyperpigmentation of skin and photosensitivity along with painful bullae in sun-exposed areas. It is due to deficiency of uroporphyrinogen III decarboxylase enzyme which takes part in heme synthesis. The deficiency could be genetic or sporadic. Iron therapy and hepatitis C infection are known to precipitate these lesions. We report a case of PCT in a woman undergoing chronic maintenance hemodialysis, review the literature, and discuss the problems with management specific to the dialysis population. |
first_indexed | 2024-04-10T09:57:17Z |
format | Article |
id | doaj.art-1210af1c6a944a8abdf47b1f061a07bb |
institution | Directory Open Access Journal |
issn | 2666-1802 2666-1810 |
language | English |
last_indexed | 2024-04-10T09:57:17Z |
publishDate | 2023-01-01 |
publisher | Wolters Kluwer Medknow Publications |
record_format | Article |
series | APIK Journal of Internal Medicine |
spelling | doaj.art-1210af1c6a944a8abdf47b1f061a07bb2023-02-16T12:03:51ZengWolters Kluwer Medknow PublicationsAPIK Journal of Internal Medicine2666-18022666-18102023-01-01111535510.4103/ajim.ajim_65_21Porphyria cutanea tarda: An uncommon condition in a patient on chronic hemodialysisYedabettu Janardhana AnupamaYabagodu Ramavakoda ParameshwaraPatients with chronic kidney disease can have many dermatological manifestations. One of the very rare conditions is porphyria cutanea tarda (PCT), which manifests with hyperpigmentation of skin and photosensitivity along with painful bullae in sun-exposed areas. It is due to deficiency of uroporphyrinogen III decarboxylase enzyme which takes part in heme synthesis. The deficiency could be genetic or sporadic. Iron therapy and hepatitis C infection are known to precipitate these lesions. We report a case of PCT in a woman undergoing chronic maintenance hemodialysis, review the literature, and discuss the problems with management specific to the dialysis population.http://www.ajim.in/article.asp?issn=2666-1802;year=2023;volume=11;issue=1;spage=53;epage=55;aulast=Anupamabullous lesiondermatological manifestationdialysishyperpigmentationiron therapyporphyria cutanea tarda |
spellingShingle | Yedabettu Janardhana Anupama Yabagodu Ramavakoda Parameshwara Porphyria cutanea tarda: An uncommon condition in a patient on chronic hemodialysis APIK Journal of Internal Medicine bullous lesion dermatological manifestation dialysis hyperpigmentation iron therapy porphyria cutanea tarda |
title | Porphyria cutanea tarda: An uncommon condition in a patient on chronic hemodialysis |
title_full | Porphyria cutanea tarda: An uncommon condition in a patient on chronic hemodialysis |
title_fullStr | Porphyria cutanea tarda: An uncommon condition in a patient on chronic hemodialysis |
title_full_unstemmed | Porphyria cutanea tarda: An uncommon condition in a patient on chronic hemodialysis |
title_short | Porphyria cutanea tarda: An uncommon condition in a patient on chronic hemodialysis |
title_sort | porphyria cutanea tarda an uncommon condition in a patient on chronic hemodialysis |
topic | bullous lesion dermatological manifestation dialysis hyperpigmentation iron therapy porphyria cutanea tarda |
url | http://www.ajim.in/article.asp?issn=2666-1802;year=2023;volume=11;issue=1;spage=53;epage=55;aulast=Anupama |
work_keys_str_mv | AT yedabettujanardhanaanupama porphyriacutaneatardaanuncommonconditioninapatientonchronichemodialysis AT yabagoduramavakodaparameshwara porphyriacutaneatardaanuncommonconditioninapatientonchronichemodialysis |