Selective Inhibition of Histone Deacetylase Class IIa With MC1568 Ameliorates Podocyte Injury

Selective Inhibition of Histone Deacetylase Class IIa With MC1568 Ameliorates Podocyte Injury

Histone deacetylases (HDACs) inhibitors are promising therapeutic agents against proteinuric kidney diseases, here, we investigated the effect of MC1568, a selective inhibitor of HDAC class IIa, on the development and progression of nephrotic syndrome in a murine model induced by Adriamycin (ADR). I...

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Bibliographic Details
Main Authors: Xu He, Tao Sun, Pei Zhang, Zhengkun Xia, Chunlin Gao, Hongqi Ren, Daxi Ji
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Medicine
Subjects:
podocyte injury
proteinuria
HDAC
β-catenin
nephrotic syndrome
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2022.848938/full

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