Dietary choline and betaine intake, cardio-metabolic risk factors and prevalence of metabolic syndrome among overweight and obese adults
Abstract Background Choline is an important metabolite involved in phospholipids synthesis, including serum lipids, and is the immediate precursor of betaine. There are numerous studies with inconsistent results that evaluated the association between dietary choline intakes with cardiovascular risk...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-03-01
|
| Series: | BMC Endocrine Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12902-023-01323-4 |
| _version_ | 1797853697703673856 |
|---|---|
| author | Mohammad Sadegh Pour Abbasi Ayda Zahiri Tousi Yalda Yazdani Sahar Vahdat Farshad Gharebakhshi Negin Nikrad Ali Manzouri Abnoos Mokhtari Ardekani Faria Jafarzadeh |
| author_facet | Mohammad Sadegh Pour Abbasi Ayda Zahiri Tousi Yalda Yazdani Sahar Vahdat Farshad Gharebakhshi Negin Nikrad Ali Manzouri Abnoos Mokhtari Ardekani Faria Jafarzadeh |
| author_sort | Mohammad Sadegh Pour Abbasi |
| collection | DOAJ |
| description | Abstract Background Choline is an important metabolite involved in phospholipids synthesis, including serum lipids, and is the immediate precursor of betaine. There are numerous studies with inconsistent results that evaluated the association between dietary choline intakes with cardiovascular risk factors. In addition, the association between dietary betaine and choline intakes with cardio-metabolic risk factors is not well studied. In the current study, our aim was to evaluate dietary choline and betaine intakes in the usual diet of obese individuals and to assess its association with serum lipids, blood pressure and glycemic markers among obese individuals. Methods We recruited a total number of 359 obese people aged between 20 and 50 years in the present study. A semi-quantitative food frequency questionnaire (FFQ) was used for dietary assessment; dietary choline and betaine intakes were calculated using the United States Department of Agriculture (USDA) database. National cholesterol education program adult treatment panel (NCEP-ATP)-III criteria was used metabolic syndrome (MetS) definition. Enzymatic methods were used to assess biochemical variables. Body composition was measured with the bioelectrical impedance analysis (BIA) method. Results Higher body mass index (BMI), waist to hip ratio (WHR), fat-free mass (FFM) and basal metabolic rate (BMR) were observed in higher tertiles of dietary choline intake (P < 0.01). There was no significant difference in terms of biochemical parameters among different tertiles of dietary choline intake, while systolic blood pressure (SBP) and diastolic blood pressure (DBP) were reduced in higher betaine tertiles (P < 0.05). For total dietary choline and betaine intakes, there was a reduction in DBP and low density lipoprotein (LDL) concentrations (P < 0.05). Also, a non-significant reduction in serum total cholesterol (TC), triglyceride (TG) and MetS prevalence was observed in higher tertiles of dietary choline and betaine intakes. After classification of the study population according to MetS status, there was no significant difference in biochemical variables in subjects with MetS (P > 0.05), while in the non-MetS group, SBP, DBP, TG and insulin levels reduced in higher tertiles of dietary betaine and choline (P > 0.05). Conclusion According to our findings, higher dietary intakes of choline and betaine were associated with lower levels of blood pressure and LDL concentrations among obese individuals. Further studies are warranted to confirm the results of the current study. |
| first_indexed | 2024-04-09T19:54:54Z |
| format | Article |
| id | doaj.art-12136393197c47e0b106aa08d0428705 |
| institution | Directory Open Access Journal |
| issn | 1472-6823 |
| language | English |
| last_indexed | 2024-04-09T19:54:54Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj.art-12136393197c47e0b106aa08d04287052023-04-03T05:30:18ZengBMCBMC Endocrine Disorders1472-68232023-03-0123111110.1186/s12902-023-01323-4Dietary choline and betaine intake, cardio-metabolic risk factors and prevalence of metabolic syndrome among overweight and obese adultsMohammad Sadegh Pour Abbasi0Ayda Zahiri Tousi1Yalda Yazdani2Sahar Vahdat3Farshad Gharebakhshi4Negin Nikrad5Ali Manzouri6Abnoos Mokhtari Ardekani7Faria Jafarzadeh8Department of Cardiovascular Surgery, Kashan University of Medical SciencesRazavi Cancer Research Center, Razavi Hospital, Imam Reza International UniversityImmunology Research Center, Tabriz University of Medical SciencesIsfahan Kidney Disease Research Center, School of Medicine, Khorshid Hospital, Isfahan University of Medical SciencesDepartment of Radiology, School of Medicne, Imam Hossein Hospital, Shahid Beheshti University of Medical SciencesStudent Research Committee, Tabriz University of Medical SciencesHealth Policy Research Center, Shiraz University of Medical SciencesEndocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Science, & Physiology Research Center, Kerman University of Medical SciencesDepartment of Internal Medicine, School of Medicine, North Khorasan University of Medical SciencesAbstract Background Choline is an important metabolite involved in phospholipids synthesis, including serum lipids, and is the immediate precursor of betaine. There are numerous studies with inconsistent results that evaluated the association between dietary choline intakes with cardiovascular risk factors. In addition, the association between dietary betaine and choline intakes with cardio-metabolic risk factors is not well studied. In the current study, our aim was to evaluate dietary choline and betaine intakes in the usual diet of obese individuals and to assess its association with serum lipids, blood pressure and glycemic markers among obese individuals. Methods We recruited a total number of 359 obese people aged between 20 and 50 years in the present study. A semi-quantitative food frequency questionnaire (FFQ) was used for dietary assessment; dietary choline and betaine intakes were calculated using the United States Department of Agriculture (USDA) database. National cholesterol education program adult treatment panel (NCEP-ATP)-III criteria was used metabolic syndrome (MetS) definition. Enzymatic methods were used to assess biochemical variables. Body composition was measured with the bioelectrical impedance analysis (BIA) method. Results Higher body mass index (BMI), waist to hip ratio (WHR), fat-free mass (FFM) and basal metabolic rate (BMR) were observed in higher tertiles of dietary choline intake (P < 0.01). There was no significant difference in terms of biochemical parameters among different tertiles of dietary choline intake, while systolic blood pressure (SBP) and diastolic blood pressure (DBP) were reduced in higher betaine tertiles (P < 0.05). For total dietary choline and betaine intakes, there was a reduction in DBP and low density lipoprotein (LDL) concentrations (P < 0.05). Also, a non-significant reduction in serum total cholesterol (TC), triglyceride (TG) and MetS prevalence was observed in higher tertiles of dietary choline and betaine intakes. After classification of the study population according to MetS status, there was no significant difference in biochemical variables in subjects with MetS (P > 0.05), while in the non-MetS group, SBP, DBP, TG and insulin levels reduced in higher tertiles of dietary betaine and choline (P > 0.05). Conclusion According to our findings, higher dietary intakes of choline and betaine were associated with lower levels of blood pressure and LDL concentrations among obese individuals. Further studies are warranted to confirm the results of the current study.https://doi.org/10.1186/s12902-023-01323-4CholineBetaineBlood pressureLipid profileMetabolic syndrome |
| spellingShingle | Mohammad Sadegh Pour Abbasi Ayda Zahiri Tousi Yalda Yazdani Sahar Vahdat Farshad Gharebakhshi Negin Nikrad Ali Manzouri Abnoos Mokhtari Ardekani Faria Jafarzadeh Dietary choline and betaine intake, cardio-metabolic risk factors and prevalence of metabolic syndrome among overweight and obese adults BMC Endocrine Disorders Choline Betaine Blood pressure Lipid profile Metabolic syndrome |
| title | Dietary choline and betaine intake, cardio-metabolic risk factors and prevalence of metabolic syndrome among overweight and obese adults |
| title_full | Dietary choline and betaine intake, cardio-metabolic risk factors and prevalence of metabolic syndrome among overweight and obese adults |
| title_fullStr | Dietary choline and betaine intake, cardio-metabolic risk factors and prevalence of metabolic syndrome among overweight and obese adults |
| title_full_unstemmed | Dietary choline and betaine intake, cardio-metabolic risk factors and prevalence of metabolic syndrome among overweight and obese adults |
| title_short | Dietary choline and betaine intake, cardio-metabolic risk factors and prevalence of metabolic syndrome among overweight and obese adults |
| title_sort | dietary choline and betaine intake cardio metabolic risk factors and prevalence of metabolic syndrome among overweight and obese adults |
| topic | Choline Betaine Blood pressure Lipid profile Metabolic syndrome |
| url | https://doi.org/10.1186/s12902-023-01323-4 |
| work_keys_str_mv | AT mohammadsadeghpourabbasi dietarycholineandbetaineintakecardiometabolicriskfactorsandprevalenceofmetabolicsyndromeamongoverweightandobeseadults AT aydazahiritousi dietarycholineandbetaineintakecardiometabolicriskfactorsandprevalenceofmetabolicsyndromeamongoverweightandobeseadults AT yaldayazdani dietarycholineandbetaineintakecardiometabolicriskfactorsandprevalenceofmetabolicsyndromeamongoverweightandobeseadults AT saharvahdat dietarycholineandbetaineintakecardiometabolicriskfactorsandprevalenceofmetabolicsyndromeamongoverweightandobeseadults AT farshadgharebakhshi dietarycholineandbetaineintakecardiometabolicriskfactorsandprevalenceofmetabolicsyndromeamongoverweightandobeseadults AT neginnikrad dietarycholineandbetaineintakecardiometabolicriskfactorsandprevalenceofmetabolicsyndromeamongoverweightandobeseadults AT alimanzouri dietarycholineandbetaineintakecardiometabolicriskfactorsandprevalenceofmetabolicsyndromeamongoverweightandobeseadults AT abnoosmokhtariardekani dietarycholineandbetaineintakecardiometabolicriskfactorsandprevalenceofmetabolicsyndromeamongoverweightandobeseadults AT fariajafarzadeh dietarycholineandbetaineintakecardiometabolicriskfactorsandprevalenceofmetabolicsyndromeamongoverweightandobeseadults |