Relationship between Semi-Quantitative Parameters of Thallium-201 Myocardial Perfusion Imaging and Coronary Artery Disease
This study aimed to investigate the diagnostic performance of semi-quantitative parameters of thallium-201 myocardial perfusion imaging (MPI) for coronary artery disease (CAD). From January to December 2017, patients were enrolled who had undergone Tl-201 MPI and received cardiac catheterization for...
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| Format: | Article |
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MDPI AG
2020-09-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/10/10/772 |
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| author | Chin-Chuan Chang Ming-Hui Yang Chih-Ting Liu Hsiu-Lan Chu Chia-Yang Lin Wei-Jheng Yen Chao-Yu Chung Sheng-Yow Ho Yu-Chang Tyan |
| author_facet | Chin-Chuan Chang Ming-Hui Yang Chih-Ting Liu Hsiu-Lan Chu Chia-Yang Lin Wei-Jheng Yen Chao-Yu Chung Sheng-Yow Ho Yu-Chang Tyan |
| author_sort | Chin-Chuan Chang |
| collection | DOAJ |
| description | This study aimed to investigate the diagnostic performance of semi-quantitative parameters of thallium-201 myocardial perfusion imaging (MPI) for coronary artery disease (CAD). From January to December 2017, patients were enrolled who had undergone Tl-201 MPI and received cardiac catheterization for coronary artery disease within three months of MPI. Receiver operating characteristics (ROC) analysis was used to determine the optimal cutoff values of semi-quantitative parameters. A comparison of the sensitivity and specificity of these parameters based on different subgroupings was further performed. A total of 130 patients were enrolled for further analysis. Among the collected parameters, the stress total perfusion deficit (sTPD) had the highest value of the area under curve (0.813) under the optimal cutoff value of 3.5%, with a sensitivity and specificity of 73.5% and 74.5%, respectively (<i>p</i> = 0.0000), for the diagnosis of CAD. With further subgrouping analysis based on history of diabetes or dyslipidemia, the sensitivity and specificity showed similar results. Based on the currently collected data and image acquisition conditions, the sTPD parameter has a clinical role for the diagnosis of CAD with a cutoff value of 3.5%. |
| first_indexed | 2024-03-10T15:55:33Z |
| format | Article |
| id | doaj.art-1214e8378221477994c52c8a519ff2c6 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T15:55:33Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-1214e8378221477994c52c8a519ff2c62023-11-20T15:37:47ZengMDPI AGDiagnostics2075-44182020-09-01101077210.3390/diagnostics10100772Relationship between Semi-Quantitative Parameters of Thallium-201 Myocardial Perfusion Imaging and Coronary Artery DiseaseChin-Chuan Chang0Ming-Hui Yang1Chih-Ting Liu2Hsiu-Lan Chu3Chia-Yang Lin4Wei-Jheng Yen5Chao-Yu Chung6Sheng-Yow Ho7Yu-Chang Tyan8Department of Nuclear Medicine, Kaohsiung Medical University Hospital, Kaohsiung 80756, TaiwanDepartment of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung 81362, TaiwanDepartment of Nuclear Medicine, Kaohsiung Medical University Hospital, Kaohsiung 80756, TaiwanDepartment of Nuclear Medicine, Kaohsiung Medical University Hospital, Kaohsiung 80756, TaiwanDepartment of Nuclear Medicine, Kaohsiung Medical University Hospital, Kaohsiung 80756, TaiwanDepartment of Nuclear Medicine, Kaohsiung Medical University Hospital, Kaohsiung 80756, TaiwanDepartment of Chemistry, National Sun Yat-sen University, Kaohsiung 80424, TaiwanDepartment of Radiation Oncology, Chi Mei Medical Center, Tainan 71004, TaiwanDepartment of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung 80708, TaiwanThis study aimed to investigate the diagnostic performance of semi-quantitative parameters of thallium-201 myocardial perfusion imaging (MPI) for coronary artery disease (CAD). From January to December 2017, patients were enrolled who had undergone Tl-201 MPI and received cardiac catheterization for coronary artery disease within three months of MPI. Receiver operating characteristics (ROC) analysis was used to determine the optimal cutoff values of semi-quantitative parameters. A comparison of the sensitivity and specificity of these parameters based on different subgroupings was further performed. A total of 130 patients were enrolled for further analysis. Among the collected parameters, the stress total perfusion deficit (sTPD) had the highest value of the area under curve (0.813) under the optimal cutoff value of 3.5%, with a sensitivity and specificity of 73.5% and 74.5%, respectively (<i>p</i> = 0.0000), for the diagnosis of CAD. With further subgrouping analysis based on history of diabetes or dyslipidemia, the sensitivity and specificity showed similar results. Based on the currently collected data and image acquisition conditions, the sTPD parameter has a clinical role for the diagnosis of CAD with a cutoff value of 3.5%.https://www.mdpi.com/2075-4418/10/10/772stress perfusion deficitsemi-quantitative parametersthallium-201myocardial perfusion imagingcoronary artery disease |
| spellingShingle | Chin-Chuan Chang Ming-Hui Yang Chih-Ting Liu Hsiu-Lan Chu Chia-Yang Lin Wei-Jheng Yen Chao-Yu Chung Sheng-Yow Ho Yu-Chang Tyan Relationship between Semi-Quantitative Parameters of Thallium-201 Myocardial Perfusion Imaging and Coronary Artery Disease Diagnostics stress perfusion deficit semi-quantitative parameters thallium-201 myocardial perfusion imaging coronary artery disease |
| title | Relationship between Semi-Quantitative Parameters of Thallium-201 Myocardial Perfusion Imaging and Coronary Artery Disease |
| title_full | Relationship between Semi-Quantitative Parameters of Thallium-201 Myocardial Perfusion Imaging and Coronary Artery Disease |
| title_fullStr | Relationship between Semi-Quantitative Parameters of Thallium-201 Myocardial Perfusion Imaging and Coronary Artery Disease |
| title_full_unstemmed | Relationship between Semi-Quantitative Parameters of Thallium-201 Myocardial Perfusion Imaging and Coronary Artery Disease |
| title_short | Relationship between Semi-Quantitative Parameters of Thallium-201 Myocardial Perfusion Imaging and Coronary Artery Disease |
| title_sort | relationship between semi quantitative parameters of thallium 201 myocardial perfusion imaging and coronary artery disease |
| topic | stress perfusion deficit semi-quantitative parameters thallium-201 myocardial perfusion imaging coronary artery disease |
| url | https://www.mdpi.com/2075-4418/10/10/772 |
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