Probing microstructural differences that manifest in human blood after taking aspirin using thixo-elasto-visco-plastic modeling and series of physical processes
Although prophylactic use of low dosage acetylsalicylic acid (aspirin) to inhibit the effects of platelet aggregation is common, a few, if any, rheological studies validating the change in the physical and mechanical properties of human blood post-aspirin administration have been reported. Recent wo...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
AIP Publishing LLC
2021-11-01
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| Series: | AIP Advances |
| Online Access: | http://dx.doi.org/10.1063/5.0074608 |
| _version_ | 1819260352998670336 |
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| author | Matthew Armstrong Erin Milner Dorian Bailey Andre Pincot Thomas Brown Lam Nguyen Kevin O’Donovan Chi Nguyen Trevor Corrigan |
| author_facet | Matthew Armstrong Erin Milner Dorian Bailey Andre Pincot Thomas Brown Lam Nguyen Kevin O’Donovan Chi Nguyen Trevor Corrigan |
| author_sort | Matthew Armstrong |
| collection | DOAJ |
| description | Although prophylactic use of low dosage acetylsalicylic acid (aspirin) to inhibit the effects of platelet aggregation is common, a few, if any, rheological studies validating the change in the physical and mechanical properties of human blood post-aspirin administration have been reported. Recent work modeling the rheological behavior of thixo-elasto-visco-plastic materials, such as human blood, indicates that they have all the hallmark features of a complex material, including shear-thinning, viscoelasticity, yield stress, and thixotropy. Using human blood rheological data collected on a Discovery Hybrid Rheometer, before and after a 14-day protocol of once daily 81 mg aspirin tablet, we compare the mechanical properties with the recently published enhanced thixotropic modified Horner–Armstrong–Wagner–Beris thixo-elasto-visco-plastic model and sequence of physical processes. We do so to highlight the subtle shift in mechanical properties in terms of the “liquid-like” and “solid-like” nature of blood. We will show both before and after parametric analysis, profile, and comparison, as well as the before and after aspirin elastic and viscous properties of the human blood. |
| first_indexed | 2024-12-23T19:24:33Z |
| format | Article |
| id | doaj.art-1215152b115b4e1698f2214a87fa748a |
| institution | Directory Open Access Journal |
| issn | 2158-3226 |
| language | English |
| last_indexed | 2024-12-23T19:24:33Z |
| publishDate | 2021-11-01 |
| publisher | AIP Publishing LLC |
| record_format | Article |
| series | AIP Advances |
| spelling | doaj.art-1215152b115b4e1698f2214a87fa748a2022-12-21T17:34:04ZengAIP Publishing LLCAIP Advances2158-32262021-11-011111115226115226-1910.1063/5.0074608Probing microstructural differences that manifest in human blood after taking aspirin using thixo-elasto-visco-plastic modeling and series of physical processesMatthew Armstrong0Erin Milner12Dorian Bailey34Andre Pincot56Thomas Brown78Lam Nguyen910Kevin O’Donovan1112Chi Nguyen13Trevor Corrigan14Department of Chemistry and Life Science, United States Military Academy, West Point, New York 10996, USADepartment of Chemistry and Life Science, United States Military Academy, West Point, New York 10996, USADepartment of Chemistry and Life Science, United States Military Academy, West Point, New York 10996, USADepartment of Chemistry and Life Science, United States Military Academy, West Point, New York 10996, USADepartment of Chemistry and Life Science, United States Military Academy, West Point, New York 10996, USADepartment of Chemistry and Life Science, United States Military Academy, West Point, New York 10996, USADepartment of Chemistry and Life Science, United States Military Academy, West Point, New York 10996, USADepartment of Chemistry and Life Science, United States Military Academy, West Point, New York 10996, USADepartment of Chemistry and Life Science, United States Military Academy, West Point, New York 10996, USADepartment of Chemistry and Life Science, United States Military Academy, West Point, New York 10996, USADepartment of Chemistry and Life Science, United States Military Academy, West Point, New York 10996, USADepartment of Chemistry and Life Science, United States Military Academy, West Point, New York 10996, USADepartment of Chemistry and Life Science, United States Military Academy, West Point, New York 10996, USADepartment of Chemistry and Life Science, United States Military Academy, West Point, New York 10996, USADepartment of Chemistry and Life Science, United States Military Academy, West Point, New York 10996, USAAlthough prophylactic use of low dosage acetylsalicylic acid (aspirin) to inhibit the effects of platelet aggregation is common, a few, if any, rheological studies validating the change in the physical and mechanical properties of human blood post-aspirin administration have been reported. Recent work modeling the rheological behavior of thixo-elasto-visco-plastic materials, such as human blood, indicates that they have all the hallmark features of a complex material, including shear-thinning, viscoelasticity, yield stress, and thixotropy. Using human blood rheological data collected on a Discovery Hybrid Rheometer, before and after a 14-day protocol of once daily 81 mg aspirin tablet, we compare the mechanical properties with the recently published enhanced thixotropic modified Horner–Armstrong–Wagner–Beris thixo-elasto-visco-plastic model and sequence of physical processes. We do so to highlight the subtle shift in mechanical properties in terms of the “liquid-like” and “solid-like” nature of blood. We will show both before and after parametric analysis, profile, and comparison, as well as the before and after aspirin elastic and viscous properties of the human blood.http://dx.doi.org/10.1063/5.0074608 |
| spellingShingle | Matthew Armstrong Erin Milner Dorian Bailey Andre Pincot Thomas Brown Lam Nguyen Kevin O’Donovan Chi Nguyen Trevor Corrigan Probing microstructural differences that manifest in human blood after taking aspirin using thixo-elasto-visco-plastic modeling and series of physical processes AIP Advances |
| title | Probing microstructural differences that manifest in human blood after taking aspirin using thixo-elasto-visco-plastic modeling and series of physical processes |
| title_full | Probing microstructural differences that manifest in human blood after taking aspirin using thixo-elasto-visco-plastic modeling and series of physical processes |
| title_fullStr | Probing microstructural differences that manifest in human blood after taking aspirin using thixo-elasto-visco-plastic modeling and series of physical processes |
| title_full_unstemmed | Probing microstructural differences that manifest in human blood after taking aspirin using thixo-elasto-visco-plastic modeling and series of physical processes |
| title_short | Probing microstructural differences that manifest in human blood after taking aspirin using thixo-elasto-visco-plastic modeling and series of physical processes |
| title_sort | probing microstructural differences that manifest in human blood after taking aspirin using thixo elasto visco plastic modeling and series of physical processes |
| url | http://dx.doi.org/10.1063/5.0074608 |
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