Clinical Application of Chinese Herbal Injection for Cancer Care: Evidence-Mapping of the Systematic Reviews, Meta-analyses, and Randomized Controlled Trials
Background and objective: Cancer is a life-threatening disease worldwide and current standard therapy cannot fulfill all clinical needs. Chinese herbal injections have been widely used for cancer in Chinese and Western hospitals in China. This study aimed to apply evidence mapping in order to provid...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-05-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2021.666368/full |
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| author | Ming Yang Si-jia Zhu Chen Shen Rui Zhai Duo-duo Li Min Fang Jing-nan Xu Jing-nan Xu Ye-na Gan Lu Yang Lu Yang Zhi-ying Ren Zhi-ying Ren Ruo-xiang Zheng Nicola Robinson Nicola Robinson Jian-ping Liu Jian-ping Liu |
| author_facet | Ming Yang Si-jia Zhu Chen Shen Rui Zhai Duo-duo Li Min Fang Jing-nan Xu Jing-nan Xu Ye-na Gan Lu Yang Lu Yang Zhi-ying Ren Zhi-ying Ren Ruo-xiang Zheng Nicola Robinson Nicola Robinson Jian-ping Liu Jian-ping Liu |
| author_sort | Ming Yang |
| collection | DOAJ |
| description | Background and objective: Cancer is a life-threatening disease worldwide and current standard therapy cannot fulfill all clinical needs. Chinese herbal injections have been widely used for cancer in Chinese and Western hospitals in China. This study aimed to apply evidence mapping in order to provide an overview of the clinical application of Chinese herbal injections in cancer care based on randomized controlled trials, systematic reviews, and meta-analyses.Methods and results: Seven databases were systematically searched for eligible randomized controlled trials, systematic reviews, and meta-analyses for ten Chinese herbal injections used in cancer treatment and covered in the Chinese national essential health insurance program. Excel 2016 and RStudio were used to integrate and process the data.In total 366 randomized controlled trials and 48 systematic reviews and meta-analyses were included in the evidence mapping of herbal medicines including; Compound Kushen, Shenqi Fuzheng, Aidi, Kangai, Kanglaite, Xiaoaiping, Cinobufacin, Brucea javanica oil emulsion, Polyporus polysaccharide injection, and Astragalus polysaccharide for injection. Health insurance restricts the scope of clinical application for these herbal injections. The numbers of studies published increased, especially around 2013–2015. The most studied cancer types were lung cancer (118, 32.2%), colorectal cancer (39, 10.7%), and gastric cancer (39, 10.7%), and the most used injections were Compound Kushen (78, 21.3%), Shenqi Fuzheng (76, 20.8%), and Aidi (63, 17.2%). The most consistently reported benefits were observed for Compound Kushen, Shenqi Fuzheng, Aidi, and Kangai for tumor response, quality of life, myelosuppression, and enhancing immunity.Conclusion: The current evidence mapping provides an overview of the outcomes and effects of Chinese herbal injections used in cancer care, and offers information on their clinical application which warrants further evidence-based research in order to inform clinical and policy decision-making. |
| first_indexed | 2024-12-20T06:16:58Z |
| format | Article |
| id | doaj.art-12158c13d6954d9ca7403b45f52d087e |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-20T06:16:58Z |
| publishDate | 2021-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-12158c13d6954d9ca7403b45f52d087e2022-12-21T19:50:31ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122021-05-011210.3389/fphar.2021.666368666368Clinical Application of Chinese Herbal Injection for Cancer Care: Evidence-Mapping of the Systematic Reviews, Meta-analyses, and Randomized Controlled TrialsMing Yang0Si-jia Zhu1Chen Shen2Rui Zhai3Duo-duo Li4Min Fang5Jing-nan Xu6Jing-nan Xu7Ye-na Gan8Lu Yang9Lu Yang10Zhi-ying Ren11Zhi-ying Ren12Ruo-xiang Zheng13Nicola Robinson14Nicola Robinson15Jian-ping Liu16Jian-ping Liu17Centre for Evidence-based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, ChinaCentre for Evidence-based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, ChinaCentre for Evidence-based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, ChinaDongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, ChinaDongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, ChinaCentre for Evidence-based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, ChinaThird Affiliated Hospital, Beijing University of Chinese Medicine, Beijing, ChinaInstitute of Acupuncture and Moxibustion in Cancer Care, Beijing University of Chinese Medicine, Beijing, ChinaDongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, ChinaThird Affiliated Hospital, Beijing University of Chinese Medicine, Beijing, ChinaInstitute of Acupuncture and Moxibustion in Cancer Care, Beijing University of Chinese Medicine, Beijing, ChinaBeijing University of Chinese Medicine, Beijing, ChinaChina-Japan Friendship Hospital, Beijing, ChinaCentre for Evidence-based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, ChinaCentre for Evidence-based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, ChinaInstitute of Health and Social Care, London South Bank University, London, United KingdomCentre for Evidence-based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, ChinaInstitute of Integrated Traditional Chinese Medicine and Western Medicine, Guangzhou Medical University, Guangzhou, ChinaBackground and objective: Cancer is a life-threatening disease worldwide and current standard therapy cannot fulfill all clinical needs. Chinese herbal injections have been widely used for cancer in Chinese and Western hospitals in China. This study aimed to apply evidence mapping in order to provide an overview of the clinical application of Chinese herbal injections in cancer care based on randomized controlled trials, systematic reviews, and meta-analyses.Methods and results: Seven databases were systematically searched for eligible randomized controlled trials, systematic reviews, and meta-analyses for ten Chinese herbal injections used in cancer treatment and covered in the Chinese national essential health insurance program. Excel 2016 and RStudio were used to integrate and process the data.In total 366 randomized controlled trials and 48 systematic reviews and meta-analyses were included in the evidence mapping of herbal medicines including; Compound Kushen, Shenqi Fuzheng, Aidi, Kangai, Kanglaite, Xiaoaiping, Cinobufacin, Brucea javanica oil emulsion, Polyporus polysaccharide injection, and Astragalus polysaccharide for injection. Health insurance restricts the scope of clinical application for these herbal injections. The numbers of studies published increased, especially around 2013–2015. The most studied cancer types were lung cancer (118, 32.2%), colorectal cancer (39, 10.7%), and gastric cancer (39, 10.7%), and the most used injections were Compound Kushen (78, 21.3%), Shenqi Fuzheng (76, 20.8%), and Aidi (63, 17.2%). The most consistently reported benefits were observed for Compound Kushen, Shenqi Fuzheng, Aidi, and Kangai for tumor response, quality of life, myelosuppression, and enhancing immunity.Conclusion: The current evidence mapping provides an overview of the outcomes and effects of Chinese herbal injections used in cancer care, and offers information on their clinical application which warrants further evidence-based research in order to inform clinical and policy decision-making.https://www.frontiersin.org/articles/10.3389/fphar.2021.666368/fullchinese herbal injectioncancer caresystematic reviewrandomized controlled trialclinical applicationherbal medicine |
| spellingShingle | Ming Yang Si-jia Zhu Chen Shen Rui Zhai Duo-duo Li Min Fang Jing-nan Xu Jing-nan Xu Ye-na Gan Lu Yang Lu Yang Zhi-ying Ren Zhi-ying Ren Ruo-xiang Zheng Nicola Robinson Nicola Robinson Jian-ping Liu Jian-ping Liu Clinical Application of Chinese Herbal Injection for Cancer Care: Evidence-Mapping of the Systematic Reviews, Meta-analyses, and Randomized Controlled Trials Frontiers in Pharmacology chinese herbal injection cancer care systematic review randomized controlled trial clinical application herbal medicine |
| title | Clinical Application of Chinese Herbal Injection for Cancer Care: Evidence-Mapping of the Systematic Reviews, Meta-analyses, and Randomized Controlled Trials |
| title_full | Clinical Application of Chinese Herbal Injection for Cancer Care: Evidence-Mapping of the Systematic Reviews, Meta-analyses, and Randomized Controlled Trials |
| title_fullStr | Clinical Application of Chinese Herbal Injection for Cancer Care: Evidence-Mapping of the Systematic Reviews, Meta-analyses, and Randomized Controlled Trials |
| title_full_unstemmed | Clinical Application of Chinese Herbal Injection for Cancer Care: Evidence-Mapping of the Systematic Reviews, Meta-analyses, and Randomized Controlled Trials |
| title_short | Clinical Application of Chinese Herbal Injection for Cancer Care: Evidence-Mapping of the Systematic Reviews, Meta-analyses, and Randomized Controlled Trials |
| title_sort | clinical application of chinese herbal injection for cancer care evidence mapping of the systematic reviews meta analyses and randomized controlled trials |
| topic | chinese herbal injection cancer care systematic review randomized controlled trial clinical application herbal medicine |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2021.666368/full |
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