Prognostic Nutritional Index and Systemic Immune-inflammation Index: Possible New Parameters for COVID-19 Severity
Background: The prognostic nutritional index (PNI) parameter has been widely used in estimating the severity of COVID-19. In contrast, investigating the role of the systemic immune-inflammation index (SII) in determining the COVID-19 severity is prospective. This study aimed to investigate the poten...
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| Format: | Article |
| Language: | English |
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Universitas Padjadjaran
2023-09-01
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| Series: | Althea Medical Journal |
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| Online Access: | https://journal.fk.unpad.ac.id/index.php/amj/article/view/3061 |
| _version_ | 1797372698875133952 |
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| author | Suyoso Suyoso Amaylia Oehadian Alfreda Amelia Khotijah Marthoenis Marthoenis |
| author_facet | Suyoso Suyoso Amaylia Oehadian Alfreda Amelia Khotijah Marthoenis Marthoenis |
| author_sort | Suyoso Suyoso |
| collection | DOAJ |
| description | Background: The prognostic nutritional index (PNI) parameter has been widely used in estimating the severity of COVID-19. In contrast, investigating the role of the systemic immune-inflammation index (SII) in determining the COVID-19 severity is prospective. This study aimed to investigate the potential of PNI and SII parameters to distinguish the severity of symptoms of COVID-19.
Methods: A retrospective observational study was conducted among 209 hospitalized patients with COVID-19. Data were collected from August 2021 to February 2022 in Indonesia’s general COVID-19 referral hospital. Demographic and laboratory data, including PNI and SII, were analyzed and compared between the severe and non-severe symptoms of COVID-19 patients. The statistical analysis of the receiver operating characteristic curve (ROC) and area under curve (AUC) was conducted to predict the potential of these parameters in distinguishing the COVID-19 severity.
Results: More than half of this study’s patients (54.55%) were non-severe COVID-19. The SII values in patients with severe symptoms were significantly higher than in those with non-severe symptoms (2,445.24 vs. 1,423.28, p=0.005). In contrast, the PNI value in patients with severe COVID-19 symptoms was significantly lower than those with non-severe symptoms (38.04 vs. 33.93, p<0.001). The area under the curve (AUC) value of PNI was 0.694, meanwhile the SII was 0.635. The optimum cut-off for the PNI was <35.407, whereas the SII was >2,212.787. PNI and SII were the potential new diagnostic parameters for COVID-19 severity.
Conclusion: PNI and SII parameters can potentially distinguish the severity of symptoms of COVID-19. |
| first_indexed | 2024-03-08T18:39:35Z |
| format | Article |
| id | doaj.art-1215cf2ea6464ee388f9d43e80e08ecb |
| institution | Directory Open Access Journal |
| issn | 2337-4330 |
| language | English |
| last_indexed | 2024-03-08T18:39:35Z |
| publishDate | 2023-09-01 |
| publisher | Universitas Padjadjaran |
| record_format | Article |
| series | Althea Medical Journal |
| spelling | doaj.art-1215cf2ea6464ee388f9d43e80e08ecb2023-12-29T08:54:34ZengUniversitas PadjadjaranAlthea Medical Journal2337-43302023-09-0110310.15850/amj.v10n3.30611612Prognostic Nutritional Index and Systemic Immune-inflammation Index: Possible New Parameters for COVID-19 SeveritySuyoso Suyoso0Amaylia Oehadian1Alfreda Amelia Khotijah2Marthoenis Marthoenis3Department of Internal Medicine, Dr. Soedono Hospital, Madiun, IndonesiaDivision of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, BandungDepartment of Internal Medicine, Dr. Soedono Hospital, MadiunDepartment of Psychiatry and Mental Health Nursing, Universitas Syiah Kuala, Banda AcehBackground: The prognostic nutritional index (PNI) parameter has been widely used in estimating the severity of COVID-19. In contrast, investigating the role of the systemic immune-inflammation index (SII) in determining the COVID-19 severity is prospective. This study aimed to investigate the potential of PNI and SII parameters to distinguish the severity of symptoms of COVID-19. Methods: A retrospective observational study was conducted among 209 hospitalized patients with COVID-19. Data were collected from August 2021 to February 2022 in Indonesia’s general COVID-19 referral hospital. Demographic and laboratory data, including PNI and SII, were analyzed and compared between the severe and non-severe symptoms of COVID-19 patients. The statistical analysis of the receiver operating characteristic curve (ROC) and area under curve (AUC) was conducted to predict the potential of these parameters in distinguishing the COVID-19 severity. Results: More than half of this study’s patients (54.55%) were non-severe COVID-19. The SII values in patients with severe symptoms were significantly higher than in those with non-severe symptoms (2,445.24 vs. 1,423.28, p=0.005). In contrast, the PNI value in patients with severe COVID-19 symptoms was significantly lower than those with non-severe symptoms (38.04 vs. 33.93, p<0.001). The area under the curve (AUC) value of PNI was 0.694, meanwhile the SII was 0.635. The optimum cut-off for the PNI was <35.407, whereas the SII was >2,212.787. PNI and SII were the potential new diagnostic parameters for COVID-19 severity. Conclusion: PNI and SII parameters can potentially distinguish the severity of symptoms of COVID-19.https://journal.fk.unpad.ac.id/index.php/amj/article/view/3061covid-19 severityprognostic nutritional indexprognosissystemic immune-inflammation index |
| spellingShingle | Suyoso Suyoso Amaylia Oehadian Alfreda Amelia Khotijah Marthoenis Marthoenis Prognostic Nutritional Index and Systemic Immune-inflammation Index: Possible New Parameters for COVID-19 Severity Althea Medical Journal covid-19 severity prognostic nutritional index prognosis systemic immune-inflammation index |
| title | Prognostic Nutritional Index and Systemic Immune-inflammation Index: Possible New Parameters for COVID-19 Severity |
| title_full | Prognostic Nutritional Index and Systemic Immune-inflammation Index: Possible New Parameters for COVID-19 Severity |
| title_fullStr | Prognostic Nutritional Index and Systemic Immune-inflammation Index: Possible New Parameters for COVID-19 Severity |
| title_full_unstemmed | Prognostic Nutritional Index and Systemic Immune-inflammation Index: Possible New Parameters for COVID-19 Severity |
| title_short | Prognostic Nutritional Index and Systemic Immune-inflammation Index: Possible New Parameters for COVID-19 Severity |
| title_sort | prognostic nutritional index and systemic immune inflammation index possible new parameters for covid 19 severity |
| topic | covid-19 severity prognostic nutritional index prognosis systemic immune-inflammation index |
| url | https://journal.fk.unpad.ac.id/index.php/amj/article/view/3061 |
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