Dysregulation in erythrocyte dynamics caused by SARS-CoV-2 infection: possible role in shuffling the homeostatic puzzle during COVID-19
Introduction: The evolving COVID-19 pandemic became a hallmark in human history, not only by changing lifestyles, but also by enriching scientific knowledge on viral infection and its consequences. Objective: Although the management of cardiorespiratory changes is pivotal to a favorable prognosis du...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-04-01
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| Series: | Hematology, Transfusion and Cell Therapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S253113792200013X |
| _version_ | 1818211051213160448 |
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| author | Michelle Mendanha Mendonça Kellen Rosa da Cruz Denise da Silva Pinheiro Gean Carlos Alves Moraes Patricia Maria Ferreira Marcos Luiz Ferreira-Neto Eduardo Sérgio da Silva Reggiani Vilela Gonçalves Gustavo Rodrigues Pedrino James O. Fajemiroye Carlos Henrique Xavier |
| author_facet | Michelle Mendanha Mendonça Kellen Rosa da Cruz Denise da Silva Pinheiro Gean Carlos Alves Moraes Patricia Maria Ferreira Marcos Luiz Ferreira-Neto Eduardo Sérgio da Silva Reggiani Vilela Gonçalves Gustavo Rodrigues Pedrino James O. Fajemiroye Carlos Henrique Xavier |
| author_sort | Michelle Mendanha Mendonça |
| collection | DOAJ |
| description | Introduction: The evolving COVID-19 pandemic became a hallmark in human history, not only by changing lifestyles, but also by enriching scientific knowledge on viral infection and its consequences. Objective: Although the management of cardiorespiratory changes is pivotal to a favorable prognosis during severe clinical findings, dysregulation of other systems caused by SARS-CoV-2 infection may imbalance erythrocyte dynamics, such as a bidirectional positive feedback loop pathophysiology. Method and Results: Recent evidence shows that SARS-CoV-2 is capable of affecting the genetics and dynamics of erythrocytes and this coexists with a non-homeostatic function of cardiovascular, respiratory and renal systems during COVID-19. In hypothesis, SARS-CoV-2-induced systematical alterations of erythrocytes dynamics would constitute a setpoint for COVID-19-related multiple organ failure syndrome and death. Conclusion: The present review covers the most frequent erythrocyte-related non-homeostatic findings during COVID-19 capable of providing mechanistic clues of SARS-CoV-2-induced infection and inspiring therapeutic-oriented scientific evidence. |
| first_indexed | 2024-12-12T05:26:21Z |
| format | Article |
| id | doaj.art-1216753cfa814684a1d62b9ac9e9e7ba |
| institution | Directory Open Access Journal |
| issn | 2531-1379 |
| language | English |
| last_indexed | 2024-12-12T05:26:21Z |
| publishDate | 2022-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Hematology, Transfusion and Cell Therapy |
| spelling | doaj.art-1216753cfa814684a1d62b9ac9e9e7ba2022-12-22T00:36:27ZengElsevierHematology, Transfusion and Cell Therapy2531-13792022-04-01442235245Dysregulation in erythrocyte dynamics caused by SARS-CoV-2 infection: possible role in shuffling the homeostatic puzzle during COVID-19Michelle Mendanha Mendonça0Kellen Rosa da Cruz1Denise da Silva Pinheiro2Gean Carlos Alves Moraes3Patricia Maria Ferreira4Marcos Luiz Ferreira-Neto5Eduardo Sérgio da Silva6Reggiani Vilela Gonçalves7Gustavo Rodrigues Pedrino8James O. Fajemiroye9Carlos Henrique Xavier10Instituto de Ciências Biológicas da Universidade Federal de Goiás (UFG), Goiânia, GO, BrazilInstituto de Ciências Biológicas da Universidade Federal de Goiás (UFG), Goiânia, GO, BrazilInstituto de Ciências Biológicas da Universidade Federal de Goiás (UFG), Goiânia, GO, BrazilInstituto de Ciências Biológicas da Universidade Federal de Goiás (UFG), Goiânia, GO, BrazilInstituto de Ciências Biológicas da Universidade Federal de Goiás (UFG), Goiânia, GO, BrazilInstituto de Ciências Biomédicas da Universidade Federal de Uberlândia (ICBIM UFU), Uberlândia, MG, BrazilUniversidade Federal de São João Del-Rei (UFSJ), Divinópolis, MG, BrazilUniversidade Federal de Viçosa (UFV), Viçosa, MG, BrazilInstituto de Ciências Biológicas da Universidade Federal de Goiás (UFG), Goiânia, GO, BrazilInstituto de Ciências Biológicas da Universidade Federal de Goiás (UFG), Goiânia, GO, BrazilInstituto de Ciências Biológicas da Universidade Federal de Goiás (UFG), Goiânia, GO, Brazil; Corresponding author at: Systems Neurobiology Laboratory. Esperança Avenue – Campus II (Samambaia). Department of Physiological Sciences. Institute of Biological Sciences (ICB II – room 203). Federal University of Goiás, Goiânia-GO. Brazil. 74690-900.Introduction: The evolving COVID-19 pandemic became a hallmark in human history, not only by changing lifestyles, but also by enriching scientific knowledge on viral infection and its consequences. Objective: Although the management of cardiorespiratory changes is pivotal to a favorable prognosis during severe clinical findings, dysregulation of other systems caused by SARS-CoV-2 infection may imbalance erythrocyte dynamics, such as a bidirectional positive feedback loop pathophysiology. Method and Results: Recent evidence shows that SARS-CoV-2 is capable of affecting the genetics and dynamics of erythrocytes and this coexists with a non-homeostatic function of cardiovascular, respiratory and renal systems during COVID-19. In hypothesis, SARS-CoV-2-induced systematical alterations of erythrocytes dynamics would constitute a setpoint for COVID-19-related multiple organ failure syndrome and death. Conclusion: The present review covers the most frequent erythrocyte-related non-homeostatic findings during COVID-19 capable of providing mechanistic clues of SARS-CoV-2-induced infection and inspiring therapeutic-oriented scientific evidence.http://www.sciencedirect.com/science/article/pii/S253113792200013XCOVID-19SARS-CoV-2ErythrocyteHemoglobinHemorphins |
| spellingShingle | Michelle Mendanha Mendonça Kellen Rosa da Cruz Denise da Silva Pinheiro Gean Carlos Alves Moraes Patricia Maria Ferreira Marcos Luiz Ferreira-Neto Eduardo Sérgio da Silva Reggiani Vilela Gonçalves Gustavo Rodrigues Pedrino James O. Fajemiroye Carlos Henrique Xavier Dysregulation in erythrocyte dynamics caused by SARS-CoV-2 infection: possible role in shuffling the homeostatic puzzle during COVID-19 Hematology, Transfusion and Cell Therapy COVID-19 SARS-CoV-2 Erythrocyte Hemoglobin Hemorphins |
| title | Dysregulation in erythrocyte dynamics caused by SARS-CoV-2 infection: possible role in shuffling the homeostatic puzzle during COVID-19 |
| title_full | Dysregulation in erythrocyte dynamics caused by SARS-CoV-2 infection: possible role in shuffling the homeostatic puzzle during COVID-19 |
| title_fullStr | Dysregulation in erythrocyte dynamics caused by SARS-CoV-2 infection: possible role in shuffling the homeostatic puzzle during COVID-19 |
| title_full_unstemmed | Dysregulation in erythrocyte dynamics caused by SARS-CoV-2 infection: possible role in shuffling the homeostatic puzzle during COVID-19 |
| title_short | Dysregulation in erythrocyte dynamics caused by SARS-CoV-2 infection: possible role in shuffling the homeostatic puzzle during COVID-19 |
| title_sort | dysregulation in erythrocyte dynamics caused by sars cov 2 infection possible role in shuffling the homeostatic puzzle during covid 19 |
| topic | COVID-19 SARS-CoV-2 Erythrocyte Hemoglobin Hemorphins |
| url | http://www.sciencedirect.com/science/article/pii/S253113792200013X |
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