Targeting neuroendocrine abnormalities in Parkinson’s disease with exercise
Parkinson’s Disease (PD) is a prevalent and complex age-related neurodegenerative condition for which there are no disease-modifying treatments currently available. The pathophysiological process underlying PD remains incompletely understood but increasing evidence points to multiple system dysfunct...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1228444/full |
| _version_ | 1827822282477666304 |
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| author | Nijee S. Luthra Demetra D. Christou Angela Clow Daniel M. Corcos |
| author_facet | Nijee S. Luthra Demetra D. Christou Angela Clow Daniel M. Corcos |
| author_sort | Nijee S. Luthra |
| collection | DOAJ |
| description | Parkinson’s Disease (PD) is a prevalent and complex age-related neurodegenerative condition for which there are no disease-modifying treatments currently available. The pathophysiological process underlying PD remains incompletely understood but increasing evidence points to multiple system dysfunction. Interestingly, the past decade has produced evidence that exercise not only reduces signs and symptoms of PD but is also potentially neuroprotective. Characterizing the mechanistic pathways that are triggered by exercise and lead to positive outcomes will improve understanding of how to counter disease progression and symptomatology. In this review, we highlight how exercise regulates the neuroendocrine system, whose primary role is to respond to stress, maintain homeostasis and improve resilience to aging. We focus on a group of hormones – cortisol, melatonin, insulin, klotho, and vitamin D – that have been shown to associate with various non-motor symptoms of PD, such as mood, cognition, and sleep/circadian rhythm disorder. These hormones may represent important biomarkers to track in clinical trials evaluating effects of exercise in PD with the aim of providing evidence that patients can exert some behavioral-induced control over their disease. |
| first_indexed | 2024-03-12T01:55:50Z |
| format | Article |
| id | doaj.art-12176350909449a69de222d3476df07c |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-03-12T01:55:50Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-12176350909449a69de222d3476df07c2023-09-08T05:42:57ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-09-011710.3389/fnins.2023.12284441228444Targeting neuroendocrine abnormalities in Parkinson’s disease with exerciseNijee S. Luthra0Demetra D. Christou1Angela Clow2Daniel M. Corcos3Department of Neurology, University of California, San Francisco, San Francisco, CA, United StatesDepartment of Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Gainesville, FL, United StatesDepartment of Psychology, School of Social Sciences, University of Westminster, London, United KingdomDepartment of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, McCormick School of Engineering, Northwestern University, Chicago, IL, United StatesParkinson’s Disease (PD) is a prevalent and complex age-related neurodegenerative condition for which there are no disease-modifying treatments currently available. The pathophysiological process underlying PD remains incompletely understood but increasing evidence points to multiple system dysfunction. Interestingly, the past decade has produced evidence that exercise not only reduces signs and symptoms of PD but is also potentially neuroprotective. Characterizing the mechanistic pathways that are triggered by exercise and lead to positive outcomes will improve understanding of how to counter disease progression and symptomatology. In this review, we highlight how exercise regulates the neuroendocrine system, whose primary role is to respond to stress, maintain homeostasis and improve resilience to aging. We focus on a group of hormones – cortisol, melatonin, insulin, klotho, and vitamin D – that have been shown to associate with various non-motor symptoms of PD, such as mood, cognition, and sleep/circadian rhythm disorder. These hormones may represent important biomarkers to track in clinical trials evaluating effects of exercise in PD with the aim of providing evidence that patients can exert some behavioral-induced control over their disease.https://www.frontiersin.org/articles/10.3389/fnins.2023.1228444/fullParkinson’s diseaseexerciseneuroendocrinebiomarkersneurohormone |
| spellingShingle | Nijee S. Luthra Demetra D. Christou Angela Clow Daniel M. Corcos Targeting neuroendocrine abnormalities in Parkinson’s disease with exercise Frontiers in Neuroscience Parkinson’s disease exercise neuroendocrine biomarkers neurohormone |
| title | Targeting neuroendocrine abnormalities in Parkinson’s disease with exercise |
| title_full | Targeting neuroendocrine abnormalities in Parkinson’s disease with exercise |
| title_fullStr | Targeting neuroendocrine abnormalities in Parkinson’s disease with exercise |
| title_full_unstemmed | Targeting neuroendocrine abnormalities in Parkinson’s disease with exercise |
| title_short | Targeting neuroendocrine abnormalities in Parkinson’s disease with exercise |
| title_sort | targeting neuroendocrine abnormalities in parkinson s disease with exercise |
| topic | Parkinson’s disease exercise neuroendocrine biomarkers neurohormone |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1228444/full |
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