Isthmin 2 is decreased in preeclampsia and highly expressed in choriocarcinoma
Introduction: Isthmin 2 (ISM2) is a protein which expression in humans is almost specific to the placenta. There is no previous report in the literature that investigated this protein in preeclampsia or choriocarcinoma. Methods: We conducted a prospective, cross-sectional study that included women w...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-10-01
|
| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844020319393 |
| _version_ | 1818205686887088128 |
|---|---|
| author | Cynthia Martinez Javier González-Ramírez María E. Marín Gustavo Martínez-Coronilla Vanessa I. Meza-Reyna Rafael Mora Raul Díaz-Molina |
| author_facet | Cynthia Martinez Javier González-Ramírez María E. Marín Gustavo Martínez-Coronilla Vanessa I. Meza-Reyna Rafael Mora Raul Díaz-Molina |
| author_sort | Cynthia Martinez |
| collection | DOAJ |
| description | Introduction: Isthmin 2 (ISM2) is a protein which expression in humans is almost specific to the placenta. There is no previous report in the literature that investigated this protein in preeclampsia or choriocarcinoma. Methods: We conducted a prospective, cross-sectional study that included women with preeclampsia, gestational hypertension and normotensive pregnancy. We measured serum concentrations of ISM2 protein and performed immunohistochemistry in placenta tissues. We also performed immunohistochemistry of ISM2 in samples from choriocarcinoma and compare with lung, prostate, colon, gastric and breast cancers. Results: A total of 81 patients were included, 30 with preeclampsia, 21 with gestational hypertension and 30 controls. The ISM2 protein was found to be decreased in patients with preeclampsia compared to the control group (P = 0.036). These results were confirmed by immunohistochemistry. We also found that ISM2 protein was overexpressed in choriocarcinoma. Discussion: Taken together, our results suggest an angiogenic function for ISM2. Its serum level decreased in our patients with preeclampsia could be reflecting that it is involved in the pathogenesis of the disease; on the other hand its high expression in choriocarcinoma, indicates that ISM2 may play an active role in the angiogenesis of this and other cancers. |
| first_indexed | 2024-12-12T04:01:05Z |
| format | Article |
| id | doaj.art-1218674639da45c7893b74135eda3bf3 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-12-12T04:01:05Z |
| publishDate | 2020-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-1218674639da45c7893b74135eda3bf32022-12-22T00:39:02ZengElsevierHeliyon2405-84402020-10-01610e05096Isthmin 2 is decreased in preeclampsia and highly expressed in choriocarcinomaCynthia Martinez0Javier González-Ramírez1María E. Marín2Gustavo Martínez-Coronilla3Vanessa I. Meza-Reyna4Rafael Mora5Raul Díaz-Molina6Department of Obstetrics and Gynecology, Maternity and Children Hospital, Mexicali, B.C., 21376, MexicoFaculty of Nursing, University Autonomous of Baja California, Mexicali, B.C., 21100, MexicoSchool of Medicine, University Autonomous of Baja California, Mexicali, B.C., 21000, MexicoFaculty of Nursing, University Autonomous of Baja California, Mexicali, B.C., 21100, MexicoLaboratory of Surgical Pathology and Cytodiagnosis, Mexicali, B.C., 21389, MexicoDepartment of Obstetrics and Gynecology, Maternity and Children Hospital, Mexicali, B.C., 21376, Mexico; Faculty of Nursing, University Autonomous of Baja California, Mexicali, B.C., 21100, Mexico; School of Medicine, University Autonomous of Baja California, Mexicali, B.C., 21000, Mexico; Laboratory of Surgical Pathology and Cytodiagnosis, Mexicali, B.C., 21389, MexicoSchool of Medicine, University Autonomous of Baja California, Mexicali, B.C., 21000, Mexico; Corresponding author.Introduction: Isthmin 2 (ISM2) is a protein which expression in humans is almost specific to the placenta. There is no previous report in the literature that investigated this protein in preeclampsia or choriocarcinoma. Methods: We conducted a prospective, cross-sectional study that included women with preeclampsia, gestational hypertension and normotensive pregnancy. We measured serum concentrations of ISM2 protein and performed immunohistochemistry in placenta tissues. We also performed immunohistochemistry of ISM2 in samples from choriocarcinoma and compare with lung, prostate, colon, gastric and breast cancers. Results: A total of 81 patients were included, 30 with preeclampsia, 21 with gestational hypertension and 30 controls. The ISM2 protein was found to be decreased in patients with preeclampsia compared to the control group (P = 0.036). These results were confirmed by immunohistochemistry. We also found that ISM2 protein was overexpressed in choriocarcinoma. Discussion: Taken together, our results suggest an angiogenic function for ISM2. Its serum level decreased in our patients with preeclampsia could be reflecting that it is involved in the pathogenesis of the disease; on the other hand its high expression in choriocarcinoma, indicates that ISM2 may play an active role in the angiogenesis of this and other cancers.http://www.sciencedirect.com/science/article/pii/S2405844020319393PregnancyObstetrics and gynecologyReproductive systemEvidence-based medicineLaboratory medicineBiomarkers |
| spellingShingle | Cynthia Martinez Javier González-Ramírez María E. Marín Gustavo Martínez-Coronilla Vanessa I. Meza-Reyna Rafael Mora Raul Díaz-Molina Isthmin 2 is decreased in preeclampsia and highly expressed in choriocarcinoma Heliyon Pregnancy Obstetrics and gynecology Reproductive system Evidence-based medicine Laboratory medicine Biomarkers |
| title | Isthmin 2 is decreased in preeclampsia and highly expressed in choriocarcinoma |
| title_full | Isthmin 2 is decreased in preeclampsia and highly expressed in choriocarcinoma |
| title_fullStr | Isthmin 2 is decreased in preeclampsia and highly expressed in choriocarcinoma |
| title_full_unstemmed | Isthmin 2 is decreased in preeclampsia and highly expressed in choriocarcinoma |
| title_short | Isthmin 2 is decreased in preeclampsia and highly expressed in choriocarcinoma |
| title_sort | isthmin 2 is decreased in preeclampsia and highly expressed in choriocarcinoma |
| topic | Pregnancy Obstetrics and gynecology Reproductive system Evidence-based medicine Laboratory medicine Biomarkers |
| url | http://www.sciencedirect.com/science/article/pii/S2405844020319393 |
| work_keys_str_mv | AT cynthiamartinez isthmin2isdecreasedinpreeclampsiaandhighlyexpressedinchoriocarcinoma AT javiergonzalezramirez isthmin2isdecreasedinpreeclampsiaandhighlyexpressedinchoriocarcinoma AT mariaemarin isthmin2isdecreasedinpreeclampsiaandhighlyexpressedinchoriocarcinoma AT gustavomartinezcoronilla isthmin2isdecreasedinpreeclampsiaandhighlyexpressedinchoriocarcinoma AT vanessaimezareyna isthmin2isdecreasedinpreeclampsiaandhighlyexpressedinchoriocarcinoma AT rafaelmora isthmin2isdecreasedinpreeclampsiaandhighlyexpressedinchoriocarcinoma AT rauldiazmolina isthmin2isdecreasedinpreeclampsiaandhighlyexpressedinchoriocarcinoma |