Comparison of Deep Inspiration Breath Hold Versus Free Breathing in Radiotherapy for Left Sided Breast Cancer
ObjectivesModern breast cancer techniques, such as the deep inspiration breath-hold (DIBH) technique has been applied for left-sided breast cancer. Whether the DIBH regimen is the optimal solution for left-sided breast cancer remains unclear. This meta-analysis aims to elucidate the differences of D...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.845037/full |
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| author | Yongkai Lu Di Yang Xiaowei Zhang Yonggang Teng Wei Yuan Yuemei Zhang Ruixin He Fengwen Tang Jie Pang Bo Han Ruijuan Chen Yi Li |
| author_facet | Yongkai Lu Di Yang Xiaowei Zhang Yonggang Teng Wei Yuan Yuemei Zhang Ruixin He Fengwen Tang Jie Pang Bo Han Ruijuan Chen Yi Li |
| author_sort | Yongkai Lu |
| collection | DOAJ |
| description | ObjectivesModern breast cancer techniques, such as the deep inspiration breath-hold (DIBH) technique has been applied for left-sided breast cancer. Whether the DIBH regimen is the optimal solution for left-sided breast cancer remains unclear. This meta-analysis aims to elucidate the differences of DIBH and free-breathing (FB) for patients receiving radiotherapy for left-sided breast cancer and provide a practical reference for clinical practice.MethodsRelevant research available on PubMed, Embase, Cochrane Library, and the Web of Science published before November 30, 2021 was independently and systematically examined by two investigators. Data were extracted from eligible studies for assessing their qualities and calculating the standardized mean difference (SMD) and 95% confidence intervals (CIs) using Review Manager software 5.4 (RevMan 5.4).ResultsForty-one studies with a total of 3599 left-sided breast cancer patients were included in the meta-analysis. Compared with FB, DIBH reduced heart dose (Dmean, Dmax, V30, V10, V5), left anterior descending branch (LAD) dose (Dmean, Dmax), ipsilateral lung dose (Dmean, V20, V10, V5), and heart volume significantly. Lung volume increased greatly, and a statistically significant difference. For contralateral breast mean dose, DIBH has no obvious advantage over FB. The funnel plot suggested this study has no significant publication bias.ConclusionsAlthough DIBH has no obvious advantage over FB in contralateral breast mean dose, it can significantly reduce heart dose, LAD dose, ipsilateral lung dose, and heart volume. Conversely, it can remarkably increase the ipsilateral lung volume. This study suggests that soon DIBH could be more widely utilized in clinical practice because of its excellent dosimetric performance. |
| first_indexed | 2024-12-12T17:24:24Z |
| format | Article |
| id | doaj.art-1218f5270f0e4977beb5ac66665d7ada |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-12T17:24:24Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-1218f5270f0e4977beb5ac66665d7ada2022-12-22T00:17:33ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-04-011210.3389/fonc.2022.845037845037Comparison of Deep Inspiration Breath Hold Versus Free Breathing in Radiotherapy for Left Sided Breast CancerYongkai Lu0Di Yang1Xiaowei Zhang2Yonggang Teng3Wei Yuan4Yuemei Zhang5Ruixin He6Fengwen Tang7Jie Pang8Bo Han9Ruijuan Chen10Yi Li11Department of Radiation Oncology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Radiation Oncology, Shaanxi Provincial Tumor Hospital, Affiliated Hospital of Xi’an Jiaotong University Health Science Center, Xi’an, ChinaDepartment of Obstetrics and Gynecology, Xi’an Central Hospital, The Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Thoracic Surgery, Second Affiliated Hospital of Air Force Medical University, Xi’an, ChinaDepartment of Radiation Oncology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Radiation Oncology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Radiation Oncology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Radiation Oncology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Obstetrics and Gynecology, Xi’an Central Hospital, The Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Radiation Oncology, Weinan Central Hospital, Weinan, ChinaDepartment of Obstetrics and Gynecology, Xi’an Central Hospital, The Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Radiation Oncology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaObjectivesModern breast cancer techniques, such as the deep inspiration breath-hold (DIBH) technique has been applied for left-sided breast cancer. Whether the DIBH regimen is the optimal solution for left-sided breast cancer remains unclear. This meta-analysis aims to elucidate the differences of DIBH and free-breathing (FB) for patients receiving radiotherapy for left-sided breast cancer and provide a practical reference for clinical practice.MethodsRelevant research available on PubMed, Embase, Cochrane Library, and the Web of Science published before November 30, 2021 was independently and systematically examined by two investigators. Data were extracted from eligible studies for assessing their qualities and calculating the standardized mean difference (SMD) and 95% confidence intervals (CIs) using Review Manager software 5.4 (RevMan 5.4).ResultsForty-one studies with a total of 3599 left-sided breast cancer patients were included in the meta-analysis. Compared with FB, DIBH reduced heart dose (Dmean, Dmax, V30, V10, V5), left anterior descending branch (LAD) dose (Dmean, Dmax), ipsilateral lung dose (Dmean, V20, V10, V5), and heart volume significantly. Lung volume increased greatly, and a statistically significant difference. For contralateral breast mean dose, DIBH has no obvious advantage over FB. The funnel plot suggested this study has no significant publication bias.ConclusionsAlthough DIBH has no obvious advantage over FB in contralateral breast mean dose, it can significantly reduce heart dose, LAD dose, ipsilateral lung dose, and heart volume. Conversely, it can remarkably increase the ipsilateral lung volume. This study suggests that soon DIBH could be more widely utilized in clinical practice because of its excellent dosimetric performance.https://www.frontiersin.org/articles/10.3389/fonc.2022.845037/fullleft sided breast cancerradiotherapyfree breathingdeep inspiration breath holdmeta-analysis |
| spellingShingle | Yongkai Lu Di Yang Xiaowei Zhang Yonggang Teng Wei Yuan Yuemei Zhang Ruixin He Fengwen Tang Jie Pang Bo Han Ruijuan Chen Yi Li Comparison of Deep Inspiration Breath Hold Versus Free Breathing in Radiotherapy for Left Sided Breast Cancer Frontiers in Oncology left sided breast cancer radiotherapy free breathing deep inspiration breath hold meta-analysis |
| title | Comparison of Deep Inspiration Breath Hold Versus Free Breathing in Radiotherapy for Left Sided Breast Cancer |
| title_full | Comparison of Deep Inspiration Breath Hold Versus Free Breathing in Radiotherapy for Left Sided Breast Cancer |
| title_fullStr | Comparison of Deep Inspiration Breath Hold Versus Free Breathing in Radiotherapy for Left Sided Breast Cancer |
| title_full_unstemmed | Comparison of Deep Inspiration Breath Hold Versus Free Breathing in Radiotherapy for Left Sided Breast Cancer |
| title_short | Comparison of Deep Inspiration Breath Hold Versus Free Breathing in Radiotherapy for Left Sided Breast Cancer |
| title_sort | comparison of deep inspiration breath hold versus free breathing in radiotherapy for left sided breast cancer |
| topic | left sided breast cancer radiotherapy free breathing deep inspiration breath hold meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.845037/full |
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