The clinical significance of some serum tumor markers among chronic patients with Helicobacter pylori infections in Ibb Governorate, Yemen
Abstract Background Helicobacter pylori (H. pylori) is a carcinogenic bacterium, it is the greatest risk factor for gastric cancer (GC), according to these evidences, there may be a certain association between chronic H. pylori infections and serum levels of tumor markers. This study was conducted t...
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| Format: | Article |
| Language: | English |
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BMC
2023-10-01
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| Series: | Infectious Agents and Cancer |
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| Online Access: | https://doi.org/10.1186/s13027-023-00542-7 |
| _version_ | 1797577997182566400 |
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| author | Marwan K. Saeed B. A. Al-Ofairi Mohammed A. Hassan M. A. Al-Jahrani Ahmed M. Abdulkareem |
| author_facet | Marwan K. Saeed B. A. Al-Ofairi Mohammed A. Hassan M. A. Al-Jahrani Ahmed M. Abdulkareem |
| author_sort | Marwan K. Saeed |
| collection | DOAJ |
| description | Abstract Background Helicobacter pylori (H. pylori) is a carcinogenic bacterium, it is the greatest risk factor for gastric cancer (GC), according to these evidences, there may be a certain association between chronic H. pylori infections and serum levels of tumor markers. This study was conducted to determine serum levels of some tumor markers, namely carcinoembryonic antigen (CEA), cancer antigen 19-9 (CA19-9) and cancer antigen 72-4 (CA72-4) in patients with chronic H. pylori infections and evaluate the association between serum tumor marker levels and chronic patients with H. pylori infections in Ibb Governorate, Yemen. Subjects and methods This study involved 200 patients who had been diagnosed with H. pylori infections using a serum immunochromatography antibody test. Stool and blood samples were collected from all patients to confirm the presence of H. pylori through detection of serum H. pylori IgG antibody and stool antigen test (SAT). Additionally, serum samples were analyzed to measurement the level of certain tumor markers CEA, CA19-9 and CA72-4. These tests were conducted at various Hospitals, Gastroenterology and Hepatology clinics in Ibb governorate, Yemen from October 2019 to November 2020. Results The findings of current study showed that the prevalence of H. pylori infections by rapid anti H. pylori test were 200 (100%), 157 (78.5%) by serum H. pylori IgG antibody and 108 (54%) by SAT. In addition, the results showed that 42 (21%) of the patients had abnormal level of CEA, 30 (15%) had abnormal level of CA19-9 and 31 (15.5%) had abnormal level of CA72-4. Most importantly, the results indicated that the serum tumor marker levels CEA, CA19-9 and CA72-4 were correlated with the levels of serum H. pylori IgG antibody as well as positive results from the SAT (P < 0.05). Furthermore, the results indicated that serum tumor marker levels were associated with different infection status. Finally, the results indicated that the serum levels of tumor markers were associated with older ages, symptomatic patients and long duration of H. pylori infections (P < 0.05). Conclusion The findings of this study indicated that there is a significant association between chronic H. pylori infections and the serum levels of tumor markers (CEA, CA19-9 and CA72-4). This suggests that the patients with active chronic H. pylori infection may have an increased risk of developing GC. Therefore, monitoring and early detection of H. pylori infection and tumor markers levels in these patients may be crucial for identifying individuals at higher risk and implementing appropriate interventions. |
| first_indexed | 2024-03-10T22:16:03Z |
| format | Article |
| id | doaj.art-121aa662f2ce473f895df8443c96608e |
| institution | Directory Open Access Journal |
| issn | 1750-9378 |
| language | English |
| last_indexed | 2024-03-10T22:16:03Z |
| publishDate | 2023-10-01 |
| publisher | BMC |
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| series | Infectious Agents and Cancer |
| spelling | doaj.art-121aa662f2ce473f895df8443c96608e2023-11-19T12:25:38ZengBMCInfectious Agents and Cancer1750-93782023-10-0118111310.1186/s13027-023-00542-7The clinical significance of some serum tumor markers among chronic patients with Helicobacter pylori infections in Ibb Governorate, YemenMarwan K. Saeed0B. A. Al-Ofairi1Mohammed A. Hassan2M. A. Al-Jahrani3Ahmed M. Abdulkareem4Department of Biological Sciences, Microbiology Section, Faculty of Science, Sana’a UniversityDepartment of Biological Sciences, Microbiology Section, Faculty of Science, Sana’a UniversityPathology Department, Faculty of Medicine, Taiz UniversityDepartment of Biological Sciences, Microbiology Section, Faculty of Science, Sana’a UniversityDepartment of Biological Sciences, Microbiology Section, Faculty of Science, Sana’a UniversityAbstract Background Helicobacter pylori (H. pylori) is a carcinogenic bacterium, it is the greatest risk factor for gastric cancer (GC), according to these evidences, there may be a certain association between chronic H. pylori infections and serum levels of tumor markers. This study was conducted to determine serum levels of some tumor markers, namely carcinoembryonic antigen (CEA), cancer antigen 19-9 (CA19-9) and cancer antigen 72-4 (CA72-4) in patients with chronic H. pylori infections and evaluate the association between serum tumor marker levels and chronic patients with H. pylori infections in Ibb Governorate, Yemen. Subjects and methods This study involved 200 patients who had been diagnosed with H. pylori infections using a serum immunochromatography antibody test. Stool and blood samples were collected from all patients to confirm the presence of H. pylori through detection of serum H. pylori IgG antibody and stool antigen test (SAT). Additionally, serum samples were analyzed to measurement the level of certain tumor markers CEA, CA19-9 and CA72-4. These tests were conducted at various Hospitals, Gastroenterology and Hepatology clinics in Ibb governorate, Yemen from October 2019 to November 2020. Results The findings of current study showed that the prevalence of H. pylori infections by rapid anti H. pylori test were 200 (100%), 157 (78.5%) by serum H. pylori IgG antibody and 108 (54%) by SAT. In addition, the results showed that 42 (21%) of the patients had abnormal level of CEA, 30 (15%) had abnormal level of CA19-9 and 31 (15.5%) had abnormal level of CA72-4. Most importantly, the results indicated that the serum tumor marker levels CEA, CA19-9 and CA72-4 were correlated with the levels of serum H. pylori IgG antibody as well as positive results from the SAT (P < 0.05). Furthermore, the results indicated that serum tumor marker levels were associated with different infection status. Finally, the results indicated that the serum levels of tumor markers were associated with older ages, symptomatic patients and long duration of H. pylori infections (P < 0.05). Conclusion The findings of this study indicated that there is a significant association between chronic H. pylori infections and the serum levels of tumor markers (CEA, CA19-9 and CA72-4). This suggests that the patients with active chronic H. pylori infection may have an increased risk of developing GC. Therefore, monitoring and early detection of H. pylori infection and tumor markers levels in these patients may be crucial for identifying individuals at higher risk and implementing appropriate interventions.https://doi.org/10.1186/s13027-023-00542-7Helicobacter pyloriTumor markersChronic H. pylori infectionsCarcinoembryonic antigenCancer antigen 19-9Caner antigen 72-4 |
| spellingShingle | Marwan K. Saeed B. A. Al-Ofairi Mohammed A. Hassan M. A. Al-Jahrani Ahmed M. Abdulkareem The clinical significance of some serum tumor markers among chronic patients with Helicobacter pylori infections in Ibb Governorate, Yemen Infectious Agents and Cancer Helicobacter pylori Tumor markers Chronic H. pylori infections Carcinoembryonic antigen Cancer antigen 19-9 Caner antigen 72-4 |
| title | The clinical significance of some serum tumor markers among chronic patients with Helicobacter pylori infections in Ibb Governorate, Yemen |
| title_full | The clinical significance of some serum tumor markers among chronic patients with Helicobacter pylori infections in Ibb Governorate, Yemen |
| title_fullStr | The clinical significance of some serum tumor markers among chronic patients with Helicobacter pylori infections in Ibb Governorate, Yemen |
| title_full_unstemmed | The clinical significance of some serum tumor markers among chronic patients with Helicobacter pylori infections in Ibb Governorate, Yemen |
| title_short | The clinical significance of some serum tumor markers among chronic patients with Helicobacter pylori infections in Ibb Governorate, Yemen |
| title_sort | clinical significance of some serum tumor markers among chronic patients with helicobacter pylori infections in ibb governorate yemen |
| topic | Helicobacter pylori Tumor markers Chronic H. pylori infections Carcinoembryonic antigen Cancer antigen 19-9 Caner antigen 72-4 |
| url | https://doi.org/10.1186/s13027-023-00542-7 |
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