Evaluation of the relationship between MARCO and CD36 single-nucleotide polymorphisms and susceptibility to pulmonary tuberculosis in a Chinese Han population
Abstract Background Gene polymorphisms impact greatly on a person’s susceptibility to pulmonary tuberculosis (PTB). Macrophage receptor with collagenous structure (MARCO) and CD36 are two scavenger receptors (SRs) that can recognize Mycobacterium tuberculosis (Mtb) and play a key role in tuberculosi...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2017-07-01
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| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12879-017-2595-2 |
| _version_ | 1818286177026834432 |
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| author | Wenting Lao Hui Kang Guojiang Jin Li Chen Yang Chu Jiao Sun Bingqi Sun |
| author_facet | Wenting Lao Hui Kang Guojiang Jin Li Chen Yang Chu Jiao Sun Bingqi Sun |
| author_sort | Wenting Lao |
| collection | DOAJ |
| description | Abstract Background Gene polymorphisms impact greatly on a person’s susceptibility to pulmonary tuberculosis (PTB). Macrophage receptor with collagenous structure (MARCO) and CD36 are two scavenger receptors (SRs) that can recognize Mycobacterium tuberculosis (Mtb) and play a key role in tuberculosis infection. Gene polymorphisms of MARCO and CD36 may contribute to tuberculosis risk. Methods To investigate whether genetic polymorphisms of MARCO and CD36 are associated with susceptibility to PTB, genomic DNA samples from patients (n = 202) and healthy controls (n = 216) were collected and analyzed by polymerase chain reaction with high-resolution melting analysis. Results We studied two single nucleotide polymorphisms (SNPs) in MARCO (rs12998782 and rs17009726) and three SNPs in CD36 (rs1194182, rs3211956 and rs10499859). Rs12998782 (P = 0.018) might be associated with susceptibility to PTB. Rs1194182 (P < 0.01) and rs10499859 (P < 0.001) might be associated with resistance to PTB. Rs17009726 and rs3211956 were not associated with susceptibility/resistance to PTB. Conclusions These data showed that MARCO rs12998782 may increase PTB risk while two SNPs of CD36, rs1194182 and rs10499859 may reduce the risk, indicating MARCO and CD36 as important receptors in response to PTB. |
| first_indexed | 2024-12-13T01:20:26Z |
| format | Article |
| id | doaj.art-121d35521a8a4129a3e5f76238fa602b |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-13T01:20:26Z |
| publishDate | 2017-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-121d35521a8a4129a3e5f76238fa602b2022-12-22T00:04:14ZengBMCBMC Infectious Diseases1471-23342017-07-011711910.1186/s12879-017-2595-2Evaluation of the relationship between MARCO and CD36 single-nucleotide polymorphisms and susceptibility to pulmonary tuberculosis in a Chinese Han populationWenting Lao0Hui Kang1Guojiang Jin2Li Chen3Yang Chu4Jiao Sun5Bingqi Sun6Department of Laboratory Medicine, The First Affiliated Hospital of China Medical UniversityDepartment of Laboratory Medicine, The First Affiliated Hospital of China Medical UniversityDepartment of Laboratory Medicine, The First Affiliated Hospital of China Medical UniversityDepartment of Blood Transfusion, Shanghai East Hospital, Tongji UniversityDepartment of Laboratory Medicine, The First Affiliated Hospital of China Medical UniversityTuberculosis Research Institute of Shenyang Tenth People’s HospitalTuberculosis Research Institute of Shenyang Tenth People’s HospitalAbstract Background Gene polymorphisms impact greatly on a person’s susceptibility to pulmonary tuberculosis (PTB). Macrophage receptor with collagenous structure (MARCO) and CD36 are two scavenger receptors (SRs) that can recognize Mycobacterium tuberculosis (Mtb) and play a key role in tuberculosis infection. Gene polymorphisms of MARCO and CD36 may contribute to tuberculosis risk. Methods To investigate whether genetic polymorphisms of MARCO and CD36 are associated with susceptibility to PTB, genomic DNA samples from patients (n = 202) and healthy controls (n = 216) were collected and analyzed by polymerase chain reaction with high-resolution melting analysis. Results We studied two single nucleotide polymorphisms (SNPs) in MARCO (rs12998782 and rs17009726) and three SNPs in CD36 (rs1194182, rs3211956 and rs10499859). Rs12998782 (P = 0.018) might be associated with susceptibility to PTB. Rs1194182 (P < 0.01) and rs10499859 (P < 0.001) might be associated with resistance to PTB. Rs17009726 and rs3211956 were not associated with susceptibility/resistance to PTB. Conclusions These data showed that MARCO rs12998782 may increase PTB risk while two SNPs of CD36, rs1194182 and rs10499859 may reduce the risk, indicating MARCO and CD36 as important receptors in response to PTB.http://link.springer.com/article/10.1186/s12879-017-2595-2Pulmonary tuberculosisChinese Han populationSingle nucleotide polymorphismsMARCOCD36 |
| spellingShingle | Wenting Lao Hui Kang Guojiang Jin Li Chen Yang Chu Jiao Sun Bingqi Sun Evaluation of the relationship between MARCO and CD36 single-nucleotide polymorphisms and susceptibility to pulmonary tuberculosis in a Chinese Han population BMC Infectious Diseases Pulmonary tuberculosis Chinese Han population Single nucleotide polymorphisms MARCO CD36 |
| title | Evaluation of the relationship between MARCO and CD36 single-nucleotide polymorphisms and susceptibility to pulmonary tuberculosis in a Chinese Han population |
| title_full | Evaluation of the relationship between MARCO and CD36 single-nucleotide polymorphisms and susceptibility to pulmonary tuberculosis in a Chinese Han population |
| title_fullStr | Evaluation of the relationship between MARCO and CD36 single-nucleotide polymorphisms and susceptibility to pulmonary tuberculosis in a Chinese Han population |
| title_full_unstemmed | Evaluation of the relationship between MARCO and CD36 single-nucleotide polymorphisms and susceptibility to pulmonary tuberculosis in a Chinese Han population |
| title_short | Evaluation of the relationship between MARCO and CD36 single-nucleotide polymorphisms and susceptibility to pulmonary tuberculosis in a Chinese Han population |
| title_sort | evaluation of the relationship between marco and cd36 single nucleotide polymorphisms and susceptibility to pulmonary tuberculosis in a chinese han population |
| topic | Pulmonary tuberculosis Chinese Han population Single nucleotide polymorphisms MARCO CD36 |
| url | http://link.springer.com/article/10.1186/s12879-017-2595-2 |
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