Omeprazole treatment manifests anxiolytic effects in a cysteamine hydrochloride induced mouse model of gastrointestinal disorder
Omeprazole, a proton pump inhibitor (PPI), has widely been used to treat various gastrointestinal (GI) disorders. Notably, many clinical symptoms of GI disorders have been known to be associated with anxiety. In recent years, an exponentially increased number of subjects with abnormal ageing, neurol...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-06-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844022010751 |
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| author | Harini Sri Rethinavel Divya Bharathi Selvaraj Sathya Jeevitha Balakrishnan Jemi Feiona Vergil Andrews Jerly Helan Mary Joseph Mahesh Kandasamy |
| author_facet | Harini Sri Rethinavel Divya Bharathi Selvaraj Sathya Jeevitha Balakrishnan Jemi Feiona Vergil Andrews Jerly Helan Mary Joseph Mahesh Kandasamy |
| author_sort | Harini Sri Rethinavel |
| collection | DOAJ |
| description | Omeprazole, a proton pump inhibitor (PPI), has widely been used to treat various gastrointestinal (GI) disorders. Notably, many clinical symptoms of GI disorders have been known to be associated with anxiety. In recent years, an exponentially increased number of subjects with abnormal ageing, neurological deficits, and psychiatric problems simultaneously exhibit GI dysfunctions as well as anxiety. Considering the fact, drugs that are used to treat GI disorders can be speculated to mitigate anxiety-related symptoms, and vice versa. Although, omeprazole treatment has been reported to result in development of anxiety and neurocognitive decline, ample reports suggest that omeprazole treatment is beneficial for the positive regulation of neuroplasticity. While underlying mechanisms of omeprazole-mediated neurological alterations remain obscure, the available scientific data on the omeprazole induced adverse effects in the brain appear to be inadequate, uncertain, and controversial. Hence, this study revisited the effect of omeprazole treatment on the degree of anxiety-like behaviours in a cysteamine hydrochloride (HCl) induced mouse model of GI disorder using open field test (OFT), light-dark box (LDB) test and elevated plus maze (EPM). Results revealed that omeprazole treatment mitigates anxiety-related behaviours in the cysteamine HCl induced animal model of GI disorder. Thus, this study assuredly supports and validates the anxiolytic properties of omeprazole. However, the adverse effects associated with inappropriate intake of omeprazole may not completely be excluded. Therefore, this study advocates the future direction in determining the long-term effects of omeprazole on the brain functions. |
| first_indexed | 2024-12-12T07:20:21Z |
| format | Article |
| id | doaj.art-121d39a86ea344a5bb3193547589e343 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-12-12T07:20:21Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-121d39a86ea344a5bb3193547589e3432022-12-22T00:33:24ZengElsevierHeliyon2405-84402022-06-0186e09787Omeprazole treatment manifests anxiolytic effects in a cysteamine hydrochloride induced mouse model of gastrointestinal disorderHarini Sri Rethinavel0Divya Bharathi Selvaraj1Sathya Jeevitha Balakrishnan2Jemi Feiona Vergil Andrews3Jerly Helan Mary Joseph4Mahesh Kandasamy5Laboratory of Stem Cells and Neuroregeneration, Department of Animal Science, School of Life Sciences, Bharathidasan University, 620024, Tiruchirappalli, Tamil Nadu, IndiaLaboratory of Stem Cells and Neuroregeneration, Department of Animal Science, School of Life Sciences, Bharathidasan University, 620024, Tiruchirappalli, Tamil Nadu, IndiaLaboratory of Stem Cells and Neuroregeneration, Department of Animal Science, School of Life Sciences, Bharathidasan University, 620024, Tiruchirappalli, Tamil Nadu, IndiaLaboratory of Stem Cells and Neuroregeneration, Department of Animal Science, School of Life Sciences, Bharathidasan University, 620024, Tiruchirappalli, Tamil Nadu, IndiaLaboratory of Stem Cells and Neuroregeneration, Department of Animal Science, School of Life Sciences, Bharathidasan University, 620024, Tiruchirappalli, Tamil Nadu, IndiaLaboratory of Stem Cells and Neuroregeneration, Department of Animal Science, School of Life Sciences, Bharathidasan University, 620024, Tiruchirappalli, Tamil Nadu, India; University Grants Commission-Faculty Recharge Programme (UGC-FRP), 110002, New Delhi, India; Corresponding author.Omeprazole, a proton pump inhibitor (PPI), has widely been used to treat various gastrointestinal (GI) disorders. Notably, many clinical symptoms of GI disorders have been known to be associated with anxiety. In recent years, an exponentially increased number of subjects with abnormal ageing, neurological deficits, and psychiatric problems simultaneously exhibit GI dysfunctions as well as anxiety. Considering the fact, drugs that are used to treat GI disorders can be speculated to mitigate anxiety-related symptoms, and vice versa. Although, omeprazole treatment has been reported to result in development of anxiety and neurocognitive decline, ample reports suggest that omeprazole treatment is beneficial for the positive regulation of neuroplasticity. While underlying mechanisms of omeprazole-mediated neurological alterations remain obscure, the available scientific data on the omeprazole induced adverse effects in the brain appear to be inadequate, uncertain, and controversial. Hence, this study revisited the effect of omeprazole treatment on the degree of anxiety-like behaviours in a cysteamine hydrochloride (HCl) induced mouse model of GI disorder using open field test (OFT), light-dark box (LDB) test and elevated plus maze (EPM). Results revealed that omeprazole treatment mitigates anxiety-related behaviours in the cysteamine HCl induced animal model of GI disorder. Thus, this study assuredly supports and validates the anxiolytic properties of omeprazole. However, the adverse effects associated with inappropriate intake of omeprazole may not completely be excluded. Therefore, this study advocates the future direction in determining the long-term effects of omeprazole on the brain functions.http://www.sciencedirect.com/science/article/pii/S2405844022010751OmeprazoleAnxietyOpen field testElevated plus mazeProton pump inhibitorCysteamine hydrochloride |
| spellingShingle | Harini Sri Rethinavel Divya Bharathi Selvaraj Sathya Jeevitha Balakrishnan Jemi Feiona Vergil Andrews Jerly Helan Mary Joseph Mahesh Kandasamy Omeprazole treatment manifests anxiolytic effects in a cysteamine hydrochloride induced mouse model of gastrointestinal disorder Heliyon Omeprazole Anxiety Open field test Elevated plus maze Proton pump inhibitor Cysteamine hydrochloride |
| title | Omeprazole treatment manifests anxiolytic effects in a cysteamine hydrochloride induced mouse model of gastrointestinal disorder |
| title_full | Omeprazole treatment manifests anxiolytic effects in a cysteamine hydrochloride induced mouse model of gastrointestinal disorder |
| title_fullStr | Omeprazole treatment manifests anxiolytic effects in a cysteamine hydrochloride induced mouse model of gastrointestinal disorder |
| title_full_unstemmed | Omeprazole treatment manifests anxiolytic effects in a cysteamine hydrochloride induced mouse model of gastrointestinal disorder |
| title_short | Omeprazole treatment manifests anxiolytic effects in a cysteamine hydrochloride induced mouse model of gastrointestinal disorder |
| title_sort | omeprazole treatment manifests anxiolytic effects in a cysteamine hydrochloride induced mouse model of gastrointestinal disorder |
| topic | Omeprazole Anxiety Open field test Elevated plus maze Proton pump inhibitor Cysteamine hydrochloride |
| url | http://www.sciencedirect.com/science/article/pii/S2405844022010751 |
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